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© Andres Alcover
Scanning electron microscopy showing a conjugate formed between a T lymphocyte and an antigen presenting cell. It is worth noting the long shape of the T cell (Tc) polarized towards the antigen presenting cell (APC) and the membrane protrusions that adhere the T lymphocyte to the antigen presenting cell.
Publication : Immunity

Triggering the TCR complex causes the downregulation of nonengaged receptors by a signal transduction-dependent mechanism

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Immunity - 01 Feb 2000

San José E, Borroto A, Niedergang F, Alcover A, Alarcón B

Link to Pubmed [PMID] – 10714682

Immunity 2000 Feb;12(2):161-70

Downregulation of the TCR complex is believed to be intimately tied to T cell activation, allowing serial triggering of receptors and desensitization of stimulated cells. We studied transfected and transgenic T cells expressing CD3zeta chimeras to demonstrate that ligand engagement of the TCR or chimeras causes comodulation of nonengaged receptors. Comodulation required protein tyrosine kinase activity but not trans-phosphorylation of nonengaged receptors. The TCR appears to be downregulated by at least two mechanisms. One mechanism requires direct engagement, independent of signaling. The second requires signaling and downregulates nontriggered receptors. These results shed new light on the process of TCR downregulation and indicate that the number of downregulated TCRs cannot be assumed to equal the number of engaged receptors.

https://www.ncbi.nlm.nih.gov/pubmed/10714682