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© Andres Alcover
Scanning electron microscopy showing a conjugate formed between a T lymphocyte and an antigen presenting cell. It is worth noting the long shape of the T cell (Tc) polarized towards the antigen presenting cell (APC) and the membrane protrusions that adhere the T lymphocyte to the antigen presenting cell.
Publication : Arthritis and rheumatism

Antibodies to vimentin intermediate filaments in sera from patients with systemic lupus erythematosus

Team: Archived: Lymphocyte Cell Biology
Member: Andres Alcover
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Arthritis and rheumatism - 01 Aug 1984

Alcover A, Molano J, Renart J, Gil-Aguado A, Nieto A, Avila J

Link to Pubmed [PMID] – 6380505

Arthritis Rheum. 1984 Aug;27(8):922-8

Sera from patients with systemic lupus erythematosus and from healthy subjects were tested, using immunofluorescence and blotting techniques, for the presence of antibodies to intermediate filaments of the cytoskeleton of human skin fibroblasts. Both techniques showed that antibodies to intermediate filaments were found in a higher proportion of sera from patients (53%) than healthy subjects (9%). The antigen target was found to be the protein band that corresponded to vimentin (Mr 57,000).