Immunometabolism at the host-microbe interface
The ‘Immunobiology of Infection’ Research Unit, a team in the INSERM U1221 UMR directed by Andres Alcover, is attached to the Departments of ‘Immunology’ and ‘Cell Biology and Infection’ of Institut Pasteur, and is affiliated with the Université de Paris (Bio-SPC doctoral school).
We study the mechanisms evolved by bacterial pathogens to establish chronic infections in humans, in particular the virulence factors altering the development and metabolic regulation of immunity. Our current work is focused on Mycobacterium tuberculosis (causing Tuberculosis) and Mycobacterium ulcerans (causing Buruli ulcer). We are also interested to decipher the causes of Hidradenitis Suppurativa, a chronic inflammatory skin disease associated with metabolic and microbial alterations..