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About

Immunometabolism at the host-microbe interface

The ‘Immunobiology of Infection’ Research Unit, a team in the INSERM U1221 UMR directed by Andres Alcover, is attached to the Departments of ‘Immunology’ and ‘Cell Biology and Infection’ of Institut Pasteur, and is affiliated with the Université de Paris (Bio-SPC doctoral school).

We study the mechanisms evolved by bacterial pathogens to establish chronic infections in humans, in particular the virulence factors altering the development and metabolic regulation of immunity. Our current work is focused on Mycobacterium tuberculosis (causing Tuberculosis) and Mycobacterium ulcerans (causing Buruli ulcer). We are also interested to decipher the causes of Hidradenitis Suppurativa, a chronic inflammatory skin disease associated with metabolic and microbial alterations..

Former Members

Projects

Project
Ongoing
5 Members

Host fatty acids and immunity to Mycobacterium tuberculosis

Caroline Demangel (PI)

While the special relationship between Mycobacterium tuberculosis (Mtb) and host lipids has long been known, it remains a challenging enigma. It was clearly established that Mtb requires host fatty acids (FAs) and cholesterol to […]
Project
Ongoing
13 Members

Deciphering the causes of Hidradenitis Suppurativa

Caroline Demangel (PI)

Hidradenitis Suppurativa (HS), also known as Verneuil’s disease and acne inversa, is an incurable skin disease manifesting as recurrent, invalidating abscesses. In addition to causing intense pain, HS is commonly associated with disability, depression […]
Project
Ongoing
8 Members

Therapeutic potential of mycolactone and synthetic surrogates

Caroline Demangel (PI)

Whether released by bacteria infecting the skin or injected via the subcutaneous route, mycolactone was found to diffuse into the leukocytes of peripheral blood and lymphoid organs. With this distribution profile, the unique effects […]
Project
Ongoing
5 Members

Immunity against Mycobacterium ulcerans : the subversive role of mycolactone

Caroline Demangel (PI)

Mycobacterium ulcerans causes Buruli ulcer, a neglected tropical skin disease manifesting as chronic wounds that can leave victims with major, life-long deformity and disability. Differently from other mycobacteria, including the related M. tuberculosis and […]
Project
Ongoing
5 Members

Biomarkers of Buruli ulcer disease

Caroline Demangel (PI)

Buruli ulcer is the third most common mycobacterial disease after Tuberculosis and Leprosy. It is a chronic, necrotizing disease of the skin and soft tissues that is reported in over thirty tropical and subtropical […]
Project
Completed
3 Members

Mycobacterial phenolic glycolipids and innate host defenses

Caroline Demangel (PI)

Across different species of mycobacteria, phenolic glycolipids (PGL) share a common lipid core and phenol ring that are embedded in the cell envelope, and differ in the saccharidic portion that is exposed on the […]
Project
Completed
4 Members

Mycolactone of Mycobacterium ulcerans and the actin cytoskeleton

Caroline Demangel (PI)

A distinctive feature of the human pathogen Mycobacterium ulcerans is the production of mycolactone. This original polyketide-derived macrolide is essential for bacterial virulence and sufficient to induce ulcerative lesions in the skin that are […]

Transversal Project

Institut Carnot Pasteur MS

The Carnot Label Carnot label is granted to public research structures, showing high level R&D competencies dedicated to fostering innovation with industrial partners. The Carnot Institutes (IC) are funded to conduct upstream research capable […]

LabEx Milieu Intérieur

The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. The Milieu Intérieur Project While the immune […]

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Contact

Administrative assistant: Marie-Luce Kop Phone: +33 (0)1 40 61 33 96 Email: marie-luce.kop@pasteur.fr 25-28 Rue du Docteur Roux 75015, Paris France