Studying host-microbe interactions to discover new bioactive compounds and therapeutic targets
Our Research Unit is attached to the Departments of ‘Immunology’ and ‘Cell Biology and Infection’ of Institut Pasteur, and is affiliated with the Université de Paris (Bio-SPC doctoral school).
We study the mechanisms evolved by bacterial pathogens to establish chronic infections in humans, particularly Mycobacterium ulcerans (causing Buruli ulcer) and Mycobacterium tuberculosis (causing Tuberculosis). We are also interested to decipher the causes of Hidradenitis Suppurativa, a chronic inflammatory skin disease associated with microbiome alterations. Our long-term objective is to discover novel therapeutic targets and bioactive molecules, of interest for the treatment of Inflammation, Infectious Diseases and Cancer.