Deciphering the causes of Hidradenitis Suppurativa
Hidradenitis Suppurativa (HS), also known as Verneuil’s disease and acne inversa, is an incurable skin disease manifesting as recurrent, invalidating abscesses. In addition to causing intense pain, HS is commonly associated with disability, depression […]
Therapeutic potential of mycolactone and synthetic surrogates
Whether released by bacteria infecting the skin or injected via the subcutaneous route, mycolactone was found to diffuse into the leukocytes of peripheral blood and lymphoid organs. With this distribution profile, the unique effects […]
Immunity against Mycobacterium ulcerans : the subversive role of mycolactone
Mycobacterium ulcerans causes Buruli ulcer, a neglected tropical skin disease manifesting as chronic wounds that can leave victims with major, life-long deformity and disability. Differently from other mycobacteria, including the related M. tuberculosis and […]
Biomarkers of Buruli ulcer disease
Buruli ulcer is the third most common mycobacterial disease after Tuberculosis and Leprosy. It is a chronic, necrotizing disease of the skin and soft tissues that is reported in over thirty tropical and subtropical […]
Mycolactone of Mycobacterium ulcerans and the actin cytoskeleton
A distinctive feature of the human pathogen Mycobacterium ulcerans is the production of mycolactone. This original polyketide-derived macrolide is essential for bacterial virulence and sufficient to induce ulcerative lesions in the skin that are […]
2020Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system., Nat Commun 2020 12; 11(1): 6363.
2020Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system., PLoS Negl Trop Dis 2020 Dec; 14(12): e0008878.
2020Dysregulation of tryptophan catabolism at the host-skin microbiota interface in Hidradenitis Suppurativa., 2020 Sep 24;140598..
2017Mycolactone displays anti-inflammatory effects on the nervous system, PLoS Negl Trop Dis 2017 Nov;11(11):e0006058.
2015Shaping mycolactone for therapeutic use against inflammatory disorders, Sci Transl Med 2015 May;7(289):289ra85.
2014Synthetic variants of mycolactone bind and activate Wiskott-Aldrich syndrome proteins, J. Med. Chem. 2014 Sep;57(17):7382-95.
2014Pathogenesis of skin ulcers: lessons from the Mycobacterium ulcerans and Leishmania spp. pathogens, Cell. Mol. Life Sci. 2014 Jul;71(13):2443-50.
2013Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation, J. Clin. Invest. 2013 Apr;123(4):1501-12.
2011A diverted total synthesis of mycolactone analogues: an insight into Buruli ulcer toxins, Chemistry 2011 Dec;17(51):14413-9.
2011Mycolactone diffuses into the peripheral blood of Buruli ulcer patients–implications for diagnosis and disease monitoring, PLoS Negl Trop Dis 2011 Jul;5(7):e1237.
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