Therapeutic potential of mycolactone surrogates
Inflammation adversely affects the health of millions of people worldwide and there is an unmet medical need for better anti-inflammatory drugs. Our group evaluates the therapeutic interest of mycolactone, a polyketide-derived macrolide produced by […]
Mycolactone of M. ulcerans and immunodulation
Mycolactone is a diffusible macrolide produced by Mycobacterium ulcerans, the causative agent of a chronic skin disease called Buruli ulcer. Defective cellular immune responses, at the local and systemic levels, are hallmarks of Buruli […]
Biomarkers of Buruli ulcer disease
Buruli ulcer is the third most common mycobacterial disease after Tuberculosis and Leprosy. It is a chronic, necrotizing disease of the skin and soft tissues that is reported in over thirty tropical and subtropical […]
Mycolactone of M. ulcerans and the actin cytoskeleton
A distinctive feature of the human pathogen Mycobacterium ulcerans is the production of mycolactone. This original polyketide-derived macrolide is essential for bacterial virulence and sufficient to induce ulcerative lesions in the skin that are […]
2017Mycolactone displays anti-inflammatory effects on the nervous system, PLoS Negl Trop Dis 2017 Nov;11(11):e0006058.
2015Shaping mycolactone for therapeutic use against inflammatory disorders, Sci Transl Med 2015 May;7(289):289ra85.
2014Synthetic variants of mycolactone bind and activate Wiskott-Aldrich syndrome proteins, J. Med. Chem. 2014 Sep;57(17):7382-95.
2014Pathogenesis of skin ulcers: lessons from the Mycobacterium ulcerans and Leishmania spp. pathogens, Cell. Mol. Life Sci. 2014 Jul;71(13):2443-50.
2013Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation, J. Clin. Invest. 2013 Apr;123(4):1501-12.
2011A diverted total synthesis of mycolactone analogues: an insight into Buruli ulcer toxins, Chemistry 2011 Dec;17(51):14413-9.
2011Mycolactone diffuses into the peripheral blood of Buruli ulcer patients–implications for diagnosis and disease monitoring, PLoS Negl Trop Dis 2011 Jul;5(7):e1237.
2011Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression., Proc. Natl. Acad. Sci. U.S.A. 2011 Aug; 108(31): 12833-8.
2009Lipids of pathogenic Mycobacteria: contributions to virulence and host immune suppression, Transbound Emerg Dis 2009 Aug;56(6-7):255-68.