The UMR3525 studies several aspects of genome biology, with a focus on maintenance and evolution of genetic information. On one hand, most teams work on the organisation, expression, and replication of genomes. On the other hand, most teams study how genomes change through time by mutations, gene acquisition, DNA loss and genetic rearrangements. The key biological models are enterobacteria, Vibrio, and yeast. Recently, the developments in our labs and the integration of the Berthelot team spurred development of projects in humans (and other mammals).
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	About
Groups
Laboratory
							
Dynamics of the Genome

						Benoit Arcangioli					
				Laboratory
							
Bacterial Genome Plasticity
 
					
						Didier Mazel					
				Laboratory
							
Microbial Evolutionary Genomics

						Eduardo Rocha					
				Laboratory
							
Spatial Regulation of Genomes

						Romain Koszul					
				Laboratory
							UMR
							G5
							 
			Comparative Functional Genomics

						Camille Berthelot					
				Laboratory
							G5
							 
			Molecular diversity of microbes
 
					
						Aude Bernheim					
				Laboratory
							
Synthetic Biology

						David Bikard					
				Laboratory
							 
			Sequence Bioinformatics
 
					
						Rayan Chikhi					
				Members
Former Members
Former directors of the UMR3525 or URA2171:
- Alain Jacquier (2012-2022)
- Bernard Dujon (2000-2011)
Former principal investigators of the UMR3525 or URA2171:
- Alain Jacquier (Genetics of molecular interactions)
- Bernard Dujon (Molecular genetics of yeast, retired)
- Antoine Danchin (Genetics of bacterial genomes, retired)
- Massimo Vergassola (Physics of the biological systems)
- Frank Kunst (Bacterial genomics, deceased)
- Carmen Buchrieser (Biology of intracellular bacteria)
- Philippe Glaser (Ecology and Evolution of Antibiotics Resistance)
- Roland Brosch (Integrated Mycobacterial Pathogenomics)
Software
Fundings
Publications
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	2025Phages with a broad host range are common across ecosystems., Nat Microbiol 2025 Oct; 10(10): 2537-2549.
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	2025Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters., Sci Adv 2025 Sep; 11(36): eadw7630.
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	2025Specificity and mechanism of tRNA cleavage by the AriB Toprim nuclease of the PARIS bacterial immune system., Philos Trans R Soc Lond B Biol Sci 2025 Sep; 380(1934): 20240074.
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	2025Antibiotic perturbation of the human gut phageome preserves its individuality and promotes blooms of virulent phages., Cell Rep 2025 Aug; 44(8): 116020.
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	2025RNA Pol II-based regulations of chromosome folding., Cell Genom 2025 Aug; (): 100970.
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	2025Impact of Natural Transformation on the Acquisition of Novel Genes in Bacteria., Mol Biol Evol 2025 Jul; 42(8): .
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	2025A human homolog of SIR2 antiphage proteins mediates immunity via the Toll-like receptor pathway, Science, 2025, 389 (6758), pp.eadr8536. ⟨10.1126/science.adr8536⟩.
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	2025High-resolution map of the Plasmodium falciparum genome reveals MORC/ ApiAP2-mediated links between distant, functionally related genes, Nature Microbiology, 2025, 10 (7), pp.1665-1683. ⟨10.1038/s41564-025-02038-z⟩.
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	2025Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems, Science, 388, 6747, (2025)..
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	2025Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems., Science, 2025 May; 388(6747): eads0768.
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