The UMR3525 studies several aspects of genome biology, with a focus on maintenance and evolution of genetic information. On one hand, most teams work on the organisation, expression, and replication of genomes. On the other hand, most teams study how genomes change through time by mutations, gene acquisition, DNA loss and genetic rearrangements. The key biological models are enterobacteria, Vibrio, and yeast. Recently, the developments in our labs and the integration of the Berthelot team spurred development of projects in humans (and other mammals).
Click to view graph
Connections
About
Members
Groups
Laboratory
Dynamics of the Genome
Benoit Arcangioli
Laboratory
Bacterial Genome Plasticity
Didier Mazel
Laboratory
Microbial Evolutionary Genomics
Eduardo Rocha
Laboratory
Spatial Regulation of Genomes
Romain Koszul
Laboratory
UMR
G5
Comparative Functional Genomics
Camille Berthelot
Laboratory
G5
Molecular diversity of microbes
Aude Bernheim
Former Members
Former directors of the UMR3525 or URA2171:
- Alain Jacquier (2012-2022)
- Bernard Dujon (2000-2011)
Former principal investigators of the UMR3525 or URA2171:
- Alain Jacquier (Genetics of molecular interactions)
- Bernard Dujon (Molecular genetics of yeast, retired)
- Antoine Danchin (Genetics of bacterial genomes, retired)
- Massimo Vergassola (Physics of the biological systems)
- Frank Kunst (Bacterial genomics, deceased)
- Carmen Buchrieser (Biology of intracellular bacteria)
- Philippe Glaser (Ecology and Evolution of Antibiotics Resistance)
- Roland Brosch (Integrated Mycobacterial Pathogenomics)
Software
Fundings
Publications
Download-
2025Dynamic transitions of initiator binding coordinate the replication of the two chromosomes in Vibrio cholerae., Nat Commun 2025 Jan; 16(1): 485.
-
2025Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons., Nat Microbiol 2025 Jan; (): .
-
2024Cyclin switch tailors a cell cycle variant to orchestrate multiciliogenesis., Cell Rep 2024 Dec; (): 115103.
-
2024Exploring the diversity of anti-defense systems across prokaryotes, phages and mobile genetic elements., Nucleic Acids Res 2024 Dec; (): .
-
2024
-
2024Intragenomic conflicts with plasmids and chromosomal mobile genetic elements drive the evolution of natural transformation within species., PLoS Biol 2024 Oct; 22(10): e3002814.
-
2024RNA degradation triggered by decapping is largely independent of initial deadenylation., EMBO J 2024 Sep; (): .
-
2024Adaptation mechanisms of Clostridioides difficile to auranofin and its impact on human gut microbiota., NPJ Biofilms Microbiomes 2024 Sep; 10(1): 86.
-
2024The next-generation sequencing-chess problem., NAR Genom Bioinform 2024 Sep; 6(4): lqae144.
-
2024Conservation of antiviral systems across domains of life reveals immune genes in humans., Cell Host Microbe 2024 Aug; (): .
-
+View full list of publications