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Sudden loss of smell is a common symptom associated with COVID-19 and SARS-CoV-2 infection of neurons in the olfactory system has been reported in both hamsters and humans. The vast majority of patients with […]

Neurodevelopmental disorders(NDD) such as autism spectrum disorder (ASD), intellectual disability (ID). affect up to 15% of the population. These NDD produce disabilities which affect a person their whole life. In many cases, persons with […]

  Congenital heart surgery is a challenging surgical disciplines due to the broad spectrum of conditions and high variability of patient anatomies. Extensive understanding of the complex spatial relationship between anatomical structures is mandatory […]

This project aims at understanding the dynamical behaviour of drosophila larva. The larva is a ~10000 neurons that exhibit complex behaviour dynamics in response to external stimuli and to possible internal states. This project is […]

Understanding how the brain processes and updates sensory precepts is a key challenge to better clarify several basic and clinical issues. Sensory perception is strongly shaped by the statistical properties of the connections formed […]

Our team identified the first mutations in the SHANK3 gene, showing it’s role in autism and Phelan-McDermid Syndrome (PMS). Thanks to a donation from the French Association of Phelan-McDermid Syndrome, we will continue the […]

This project aims to characterize the mircrociruit structure of small animals’ brains and link this to how the brain processes information and encodes behavior.  The project relies on simultaneous access to recent synapse-resolution wiring […]

Depressive episodes (EDs) are characterized by a negative emotional bias consisting of attributing more negative valences to stimuli. The correction of this bias seems necessary for the effectiveness of antidepressants (AD). While the central […]

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[Version française]… Understanding mechanisms underlying normal complex behaviours and the abnormalities that accompany most neuropathologies is a primary challenge in fundamental and biomedical research. However, optimal use of the large body of genetic, molecular, […]

The phenomenon of neurogenesis in adult animals, which has therapeutic potential in treating neurodegenerative diseases, leads to several questions: What controls the pattern of connections formed by new cells? How is the stability of […]

The sense of smell has to deal with numerous odors which can trigger various affective responses. We like or dislike a given odorant even before recognizing the nature of the smell. As a result […]

[Version française]… One of the main obstacles for studying the molecular and cellular mechanisms underlying human neurodevelopment in vivo is the scarcity of experimental models. The discovery that neurons can be generated from human […]

Elucidating the structural dynamics of a PENTAMERIC LIGAND-GATED ION CHANNEL for rational DRUG design

Autism spectrum disorders (ASD) are a heterogeneous group of pervasive neurodevelopmental disorders affecting approximately 1% of the population. The diagnosis of ASD is based on impairments in reciprocal social communication and stereotyped behaviors. Behind […]

Our group is exploring the human brain using Magnetic Resonance Imaging (MRI) and electroencephalogram (EEG). These approaches are combined with our genetic data in order to better understand the genetic and phenotypic diversity of […]

Our CC model predicts that MF-GC STP diversity drives a temporal diversity of GC activity that enables temporal learning by PCs.  Population measurements of GC spiking activity are not readily available. We will use […]

Computational implications of functional synaptic diversity – a formalized hypothesis. Precise neural representations of “time” are essential for well-timed behaviors [1], but the cellular and circuit mechanisms are largely unknown.  We previously showed that […]

Contribution of dendritic integration and electrical synapses to circuit computations. Nonlinear summation of synaptic potentials in dendrites is thought to increase computational power of neurons and has been shown to contribute to feature selectivity […]

A Unique Software Platform for Complex Image Analysis Using Virtual Reality         DIVA (Data Integration and Visualization in Augmented and Virtual Environments)  is a software platform jointly developed by the Decision and Bayesian […]

Signal transduction and allosteric modulation of nicotinic acetylcholine receptors: from ion channel electrophysiology to atomic 3D structures

How does the brain distinguish between memories that closely resemble each other? The hippocampal dentate gyrus has been suggested to serve this purpose by generating non-overlapping memory representations in a process termed “pattern separation”. […]

Around 1% of children are diagnosed with autism spectrum disorders (ASD), yet there are currently no drugs designed specifically to treat their main symptoms. Working to change this is the IMI-funded EU-AIMS project. The […]

Human cytomegalovirus (CMV) is the first cause of congenital malformation resulting from viral infection, and the leading cause of mental retardation and hearing loss. We are assessing the impact of congenital CMV infection on […]

Human brain anatomy is strikingly diverse and highly inheritable: genetic factors may explain up to 80% of its variability. Genome-wide scans looking for associations between genomic polymorphism and neuroanatomical variability identify, however, just a […]

Immune cells modulate CNS activities in physiology, but peripheral immune cells are rarely found in direct contact with the neural tissue. Instead, the immune cells are thought to affect the brain remotely and indirectly, […]

A version in French is available here INTERMUSE aims to establish the concepts and observations that give access to understanding the mechanisms structuring human thought when it gives meaning to a perceptual experience. This […]

This project aims at understanding the synaptic environment at the single receptor scale. Now that large amounts of dynamical single molecule data are available and that single molecule science is slowly transitioning into a big […]

[Version française]… Cocaine addiction (CocAdd) is a major public health issue affecting 3% of the worlwide population, without validated pharmacotherapy. Nicotinic acetylcholine receptors (nAChRs)have been repeatedly associated in Human and rodent response to cocaine. […]

Microglia are extremely specialized immune cells, which reside in the CNS and play key roles in its development, homeostasis and disease. Such specialization is imposed by the peculiar environment the microglia have to live […]

Molecular and cellular determinants of functional synaptic  diversity At canonical fast synapses nanoscale alterations in the number, density and location of synaptic vesicles, calcium channels, receptors and fusion proteins play a critical role in […]

Neocortical folding is one of the most intriguing characteristics of the mammalian brain. Their pattern is very distinctive for different species, and there seems to be a remarkable relationship between convolutions and the architectonic […]

In order to characterize the mechanisms leading to autism spectrum disorders, we are studying several mouse models. These models are mutated in a gene of interest that has been associated with ASD in genetic […]

Networks provide an efficient formalism to study many complex real-world systems. They provide a natural modeling framework of structural and functional brain networks, protein interaction networks, social interactions, information and epidemic spreading, and infrastructural […]

What’s best to study humans and their infectious deseases than Human emulation system ? It’s now possible at Pasteur to develop real Organs-on-chips with cells from different sources, patient derived or cell line. At […]

The Paris Autism Research International Sib-pair (PARIS) Study has been launched as a collaborative project by Prof. M. Leboyer (Paris) and Prof. C. Gillberg (Göteborg) in the 2000s. Its main goal is to join […]

[Version française]… Lung diseases are also a major public health problem. Chronic obstructive pulmonary disease (COPD) will be the third cause of mortality worldwide in 2020 and lung cancer is the leading cause of […]

    Neuroinflammation, a specialized immune response that takes place in the central nervous system, has been linked to neurodegenerative diseases. Also, it has been demonstrated to affect important processes in the brain, such […]

[Version française]… There is experimental and biomedical evidence that the nicotinic acetylcholine receptor (nAChR) is implicated in Alzheimer’s Disease (AD) pathology. The only reasonably efficient FDA approved treatment for early stage AD, blockers of […]

Bacteria produce hundreds of volatile compounds, important for the crafting of microbe-based foods like wine, beer, or cheese. Although  the odorant chemicals emitted by bacteria were rarely characterized in the context of bacteria-bacteria or bacteria-host […]

The project SoNeTAA (Social Neuroscience for Therapeutic Approaches in Autism) combines human-human and human-machine interactions with electroencephalography (EEG) recording to approach social cognition from a situated and reciprocal standpoint. The project especially focuses on […]

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[Version française]… Drug addiction is a complex psychiatric disorder. Several predisposing factors can contribute to the vulnerability to develop this pathology, including environmental and genetic ones. Although smoking prevalence has declined in recent years, […]

We have installed a stimulation emission depletion (STED) microscope in order to assess the diversity of the nanoscale organization of synaptic molecules thought to underly synaptic strength and dynamics. Figure 1. Confocal and STED […]

Synaptic representation of multisensory information The GC layer of the CC is thought to pre-process incoming mossy fiber (MF) activity so that PCs can more easily distinguish distinct patterns associated specific sensory contexts. The […]

Bipolar disorders (BD) is a prevalent and debilitating chornic psychiatric illness that generates a considerable cost for the society. Beyond mood episodes, manic or depressive, growing evidence has shown that BD patients even during […]

Sleep difficulties are a major concern for families with ASD, but are often considered as an epiphenomenon, and therefore do not catch the attention of the medical and scientific community. In 2008, we reported […]

We implement and develop data analysis pipelines to process large neuroimaging-genetics datasets, and participate in the analysis of several very large international consortia. We have developed online and offline interactive tools to examine the […]

We are interested in deciphering the relationships that link gut microbiota with the immune system and the brain. So far, the mechanisms underlying these interplay, and most importantly their consequences, remain largely unknown. Therefore […]