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La perte soudaine de l’odorat est un symptôme fréquemment associé à la COVID-19 et l’infection par le SARS-CoV-2 des neurones du système olfactif a été signalée à la fois chez le hamster et l’humain. […]

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

This project aims at understanding the dynamical behaviour of drosophila larva. The larva is a ~10000 neurons that exhibit complex behaviour dynamics in response to external stimuli and to possible internal states. This project is […]

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Notre équipe a identifié les premières mutations du gène SHANK3, mettant en évidence son importance dans l’autisme et le syndrome de Phelan-McDermid (PMS). Grâce au don de l’Association française du syndrome de Phelan-McDermid, nous […]

Désolé, cet article est seulement disponible en EN.

This project aims to characterize the mircrociruit structure of small animals’ brains and link this to how the brain processes information and encodes behavior. The project relies on simultaneous access to recent synapse-resolution wiring […]

Désolé, cet article est seulement disponible en EN.

NEUTROBLOOD est une demande d’utilisation de données et d’échantillons biologiques collectés dans le cadre de la cohorte COSIPOP. Quel est l’objectif de NEUTROBLOOD ?  L’objectif est de mettre au point une méthode d’isolement d’un […]

L’autisme fait partie des troubles du neurodéveloppement (TND). Il se manifeste dès la petite enfance (avant l’âge de 36 mois) et a des conséquences à différents niveaux et degrés sur les sphères développementales de […]

[Version française]… Understanding mechanisms underlying normal complex behaviours and the abnormalities that accompany most neuropathologies is a primary challenge in fundamental and biomedical research. However, optimal use of the large body of genetic, molecular, […]

The phenomenon of neurogenesis in adult animals, which has therapeutic potential in treating neurodegenerative diseases, leads to several questions: What controls the pattern of connections formed by new cells? How is the stability of […]

The sense of smell has to deal with numerous odors which can trigger various affective responses. We like or dislike a given odorant even before recognizing the nature of the smell. As a result […]

[Version française]… One of the main obstacles for studying the molecular and cellular mechanisms underlying human neurodevelopment in vivo is the scarcity of experimental models. The discovery that neurons can be generated from human […]

Elucidating the structural dynamics of a PENTAMERIC LIGAND-GATED ION CHANNEL for rational DRUG design

Autism spectrum disorders (ASD) are a heterogeneous group of pervasive neurodevelopmental disorders affecting approximately 1% of the population. The diagnosis of ASD is based on impairments in reciprocal social communication and stereotyped behaviors. Behind […]

Our group is exploring the human brain using Magnetic Resonance Imaging (MRI) and electroencephalogram (EEG). These approaches are combined with our genetic data in order to better understand the genetic and phenotypic diversity of […]

A Unique Software Platform for Complex Image Analysis Using Virtual Reality     DIVA (Data Integration and Visualization in Augmented and Virtual Environments)  is a software platform jointly developed by the Decision and Bayesian Computation lab […]

Signal transduction and allosteric modulation of nicotinic acetylcholine receptors: from ion channel electrophysiology to atomic 3D structures

Around 1% of children are diagnosed with autism spectrum disorders (ASD), yet there are currently no drugs designed specifically to treat their main symptoms. Working to change this is the IMI-funded EU-AIMS project. The […]

Human cytomegalovirus (CMV) is the first cause of congenital malformation resulting from viral infection, and the leading cause of mental retardation and hearing loss. We are assessing the impact of congenital CMV infection on […]

Human brain anatomy is strikingly diverse and highly inheritable: genetic factors may explain up to 80% of its variability. Genome-wide scans looking for associations between genomic polymorphism and neuroanatomical variability identify, however, just a […]

A version in French is available here INTERMUSE aims to establish the concepts and observations that give access to understanding the mechanisms structuring human thought when it gives meaning to a perceptual experience. This […]

This project aims at understanding the synaptic environment at the single receptor scale. Now that large amounts of dynamical single molecule data are available and that single molecule science is slowly transitioning into a big […]

[Version française]… Cocaine addiction (CocAdd) is a major public health issue affecting 3% of the worlwide population, without validated pharmacotherapy. Nicotinic acetylcholine receptors (nAChRs)have been repeatedly associated in Human and rodent response to cocaine. […]

Microglia are extremely specialized immune cells, which reside in the CNS and play key roles in its development, homeostasis and disease. Such specialization is imposed by the peculiar environment the microglia have to live […]

Neocortical folding is one of the most intriguing characteristics of the mammalian brain. Their pattern is very distinctive for different species, and there seems to be a remarkable relationship between convolutions and the architectonic […]

In order to characterize the mechanisms leading to autism spectrum disorders, we are studying several mouse models. These models are mutated in a gene of interest that has been associated with ASD in genetic […]

Networks provide an efficient formalism to study many complex real-world systems. They provide a natural modeling framework of structural and functional brain networks, protein interaction networks, social interactions, information and epidemic spreading, and infrastructural […]

What’s best to study humans and their infectious deseases than Human emulation system ? It’s now possible at Pasteur to develop real Organs-on-chips with cells from different sources, patient derived or cell line. At […]

The Paris Autism Research International Sib-pair (PARIS) Study has been launched as a collaborative project by Prof. M. Leboyer (Paris) and Prof. C. Gillberg (Göteborg) in the 2000s. Its main goal is to join […]

[Version française]… Lung diseases are also a major public health problem. Chronic obstructive pulmonary disease (COPD) will be the third cause of mortality worldwide in 2020 and lung cancer is the leading cause of […]

    Neuroinflammation, a specialized immune response that takes place in the central nervous system, has been linked to neurodegenerative diseases. Also, it has been demonstrated to affect important processes in the brain, such […]

[Version française]… There is experimental and biomedical evidence that the nicotinic acetylcholine receptor (nAChR) is implicated in Alzheimer’s Disease (AD) pathology. The only reasonably efficient FDA approved treatment for early stage AD, blockers of […]

Bacteria produce hundreds of volatile compounds, important for the crafting of microbe-based foods like wine, beer, or cheese. Although  the odorant chemicals emitted by bacteria were rarely characterized in the context of bacteria-bacteria or bacteria-host […]

The project SoNeTAA (Social Neuroscience for Therapeutic Approaches in Autism) combines human-human and human-machine interactions with electroencephalography (EEG) recording to approach social cognition from a situated and reciprocal standpoint. The project especially focuses on […]

[Version française]… Drug addiction is a complex psychiatric disorder. Several predisposing factors can contribute to the vulnerability to develop this pathology, including environmental and genetic ones. Although smoking prevalence has declined in recent years, […]

Bipolar disorders (BD) is a prevalent and debilitating chornic psychiatric illness that generates a considerable cost for the society. Beyond mood episodes, manic or depressive, growing evidence has shown that BD patients even during […]

Sleep difficulties are a major concern for families with ASD, but are often considered as an epiphenomenon, and therefore do not catch the attention of the medical and scientific community. In 2008, we reported […]

We implement and develop data analysis pipelines to process large neuroimaging-genetics datasets, and participate in the analysis of several very large international consortia. We have developed online and offline interactive tools to examine the […]

We are interested in deciphering the relationships that link gut microbiota with the immune system and the brain. So far, the mechanisms underlying these interplay, and most importantly their consequences, remain largely unknown. Therefore […]