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2024Genomic and epidemiological evidence for the emergence of a L. infantum/L. donovani hybrid with unusual epidemiology in northern Italy., mBio 2024 Jun; (): e0099524.
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2023Leishmania allelic selection during experimental sand fly infection correlates with mutational signatures of oxidative DNA damage., Proc Natl Acad Sci U S A 2023 Mar; 120(10): e2220828120.
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2023Amphotericin B resistance correlates with increased fitness in vitro and in vivo in Leishmania (Mundinia) martiniquensis., Front Microbiol 2023 ; 14(): 1156061.
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2022Trifloxystrobin blocks the growth of Theileria parasites and is a promising drug to treat Buparvaquone resistance., Commun Biol 2022 Nov; 5(1): 1253.
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2022Retrospective Analysis of Leishmaniasis in Sicily (Italy) from 2013 to 2021: One-Health Impact and Future Control Strategies., Microorganisms 2022 Aug; 10(9): .
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2022Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni., ACS Infect Dis 2022 Jul; 8(7): 1356-1366.
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2022Going ballistic: Leishmania nuclear subversion of host cell plasticity., Trends Parasitol 2022 Mar; 38(3): 205-216.
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2022Experimental evolution links post-transcriptional regulation to Leishmania fitness gain., PLoS Pathog 2022 Mar; 18(3): e1010375.
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2021Genome instability drives epistatic adaptation in the human pathogen Leishmania., Proc Natl Acad Sci U S A 2021 12; 118(51): .
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2021GIP: an open-source computational pipeline for mapping genomic instability from protists to cancer cells., Nucleic Acids Res 2021 Dec; (): .
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2021Nitric oxide controls proliferation of Leishmania major by inhibiting the recruitment of permissive host cells., Immunity 2021 Dec; 54(12): 2724-2739.e10.
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2021Cutaneous Leishmaniasis in Algeria; Highlight on the Focus of M’Sila., Microorganisms 2021 Apr; 9(5): .
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2021Colonization and genetic diversification processes of Leishmania infantum in the Americas., Commun Biol 2021 01; 4(1): 139.
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2021In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition., Eur J Med Chem 2021 Jan; 210(): 112956.
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2021Dangerous Duplicity: The Dual Functions of Casein Kinase 1 in Parasite Biology and Host Subversion., Front Cell Infect Microbiol 2021 ; 11(): 655700.
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2021Identification of the Host Substratome of Leishmania-Secreted Casein Kinase 1 Using a SILAC-Based Quantitative Mass Spectrometry Assay., Front Cell Dev Biol 2021 ; 9(): 800098.
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2020Comparative transcriptomic analysis of antimony resistant and susceptible Leishmania infantum lines., Parasit Vectors 2020 Nov; 13(1): 600.
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2020Nuclear and mitochondrial genome sequencing of North-African Leishmania infantum isolates from cured and relapsed visceral leishmaniasis patients reveals variations correlating with geography and phenotype., Microb Genom 2020 10; 6(10): .
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2020Dynamic imaging reveals surface exposure of virulent Leishmania amastigotes during pyroptosis of infected macrophages., J Cell Sci 2020 06; 134(5): .
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2020Infectivity and Drug Susceptibility Profiling of Different Leishmania-Host Cell Combinations., Pathogens 2020 May; 9(5): .
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2020Leishmania dual-specificity tyrosine-regulated kinase 1 (DYRK1) is required for sustaining Leishmania stationary phase phenotype., Mol Microbiol 2020 05; 113(5): 983-1002.
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2020SILAC-based quantitative proteomics reveals pleiotropic, phenotypic modulation in primary murine macrophages infected with the protozoan pathogen Leishmania donovani., J Proteomics 2020 02; 213(): 103617.
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2020Targeting Macrophage Histone H3 Modification as a Leishmania Strategy to Dampen the NF-κB/NLRP3-Mediated Inflammatory Response., Cell Rep 2020 Feb; 30(6): 1870-1882.e4.
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2020Leishmania amazonensis Subverts the Transcription Factor Landscape in Dendritic Cells to Avoid Inflammasome Activation and Stall Maturation., Front Immunol 2020 ; 11(): 1098.
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2019Trans-Atlantic Spill Over: Deconstructing the Ecological Adaptation of Leishmania infantum in the Americas., Genes (Basel) 2019 12; 11(1): .
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2019Author Correction: Discovery of novel hit compounds with broad activity against visceral and cutaneous Leishmania species by comparative phenotypic screening., Sci Rep 2019 Jul; 9(1): 10148.
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2019Leishmania donovani 90 kD Heat Shock Protein – Impact of Phosphosites on Parasite Fitness, Infectivity and Casein Kinase Affinity., Sci Rep 2019 03; 9(1): 5074.
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2019Drug Discovery for Kinetoplastid Diseases: Future Directions., ACS Infect Dis 2019 02; 5(2): 152-157.
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2019Discovery of novel hit compounds with broad activity against visceral and cutaneous Leishmania species by comparative phenotypic screening., Sci Rep 2019 01; 9(1): 438.
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2018Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification., mBio 2018 11; 9(6): .
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2018Stage-specific expression of the proline-alanine transporter in the human pathogen Leishmania, Mol. Biochem. Parasitol. 2018 06;222:1-5.
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2018Reverse Epidemiology: An Experimental Framework to Drive Leishmania Biomarker Discovery in situ by Functional Genetic Screening Using Relevant Animal Models., Front Cell Infect Microbiol 2018 ; 8(): 325.
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2017Haplotype selection as an adaptive mechanism in the protozoan pathogen Leishmania donovani, Nat Ecol Evol 2017 Dec;1(12):1961-1969.
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2017Modulation of Aneuploidy in during Adaptation to Different and Environments and Its Impact on Gene Expression, mBio 2017 05;8(3).
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2017Old World cutaneous leishmaniasis challenges in Morocco, Algeria, Tunisia and Iran (MATI): a collaborative attempt to combat the disease, Expert Rev Vaccines 2017 May;16(5):415-417.
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2016Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth, Int J Parasitol Drugs Drug Resist 2017 04;7(1):42-50.
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2016Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor, Eur J Med Chem 2017 Jan;125:696-709.
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2016Species- and Strain-Specific Adaptation of the HSP70 Super Family in Pathogenic Trypanosomatids., Genome Biol Evol 2016 07; 8(6): 1980-95.
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2016Phenotypic Characterization of a Leishmania donovani Cyclophilin 40 Null Mutant, J. Eukaryot. Microbiol. 2016 11;63(6):823-833.
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2016From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity., Antimicrob Agents Chemother 2016 05; 60(5): 2822-33.
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2016Joining forces: first application of a rapamycin-induced dimerizable Cre system for conditional null mutant analysis in Leishmania, Mol. Microbiol. 2016 06;100(6):923-7.
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2016Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy, Cytokine 2016 May;81:101-8.
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2015Implication of different domains of the Leishmania major metacaspase in cell death and autophagy, Cell Death Dis 2015;6:e1933.
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2015Phosphoproteomic analysis of wild-type and antimony-resistant Leishmania braziliensis lines by 2D-DIGE technology, Proteomics 2015 May;.
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2015A touch of Zen: post-translational regulation of the Leishmania stress response., Cell Microbiol 2015 May; 17(5): 632-8.
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2014Simultaneous multi-parametric analysis of Leishmania and of its hosting mammal cells: A high content imaging-based method enabling sound drug discovery process, Microb. Pathog. 2014 Oct;.
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2014Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses., Mol Microbiol 2014 Jul; 93(1): 146-66.
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2014The Leishmania donovani chaperone cyclophilin 40 is essential for intracellular infection independent of its stage-specific phosphorylation status, Mol. Microbiol. 2014 Jul;93(1):80-97.
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2014Regulation dynamics of Leishmania differentiation: deconvoluting signals and identifying phosphorylation trends, Mol. Cell Proteomics 2014 Jul;13(7):1787-99.
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2014Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection., Antimicrob Agents Chemother 2014 ; 58(3): 1501-15.
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2013Enrichment of Leishmania donovani ATP-binding proteins using a staurosporine capture compound., J Proteomics 2013 Jun; 86(): 97-104.
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2012Apoptotic marker expression in the absence of cell death in staurosporine-treated Leishmania donovani., Antimicrob Agents Chemother 2013 Mar; 57(3): 1252-61.
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2012The crystal structure of the MAP kinase LmaMPK10 from Leishmania major reveals parasite-specific features and regulatory mechanisms., Structure 2012 Oct; 20(10): 1649-60.
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2012CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation, Immunity 2012 Jul;37(1):147-57.
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2011PhosTryp: a phosphorylation site predictor specific for parasitic protozoa of the family trypanosomatidae, BMC Genomics 2011;12:614.
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2011Alba-domain proteins of Trypanosoma brucei are cytoplasmic RNA-binding proteins that interact with the translation machinery, PLoS ONE 2011;6(7):e22463.
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2011Quantitative proteome profiling informs on phenotypic traits that adapt Leishmania donovani for axenic and intracellular proliferation, Cell. Microbiol. 2011 Jul;13(7):978-91.
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2011Imaging host cell-Leishmania interaction dynamics implicates parasite motility, lysosome recruitment, and host cell wounding in the infection process, Cell Host Microbe 2011 Apr;9(4):319-30.
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2011Adaptation of a 2D in-gel kinase assay to trace phosphotransferase activities in the human pathogen Leishmania donovani., J Proteomics 2011 Aug; 74(9): 1644-51.
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2010Identification of Leishmania-specific protein phosphorylation sites by LC-ESI-MS/MS and comparative genomics analyses, Proteomics 2010 Nov;10(21):3868-83.
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2010Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability., PLoS Negl Trop Dis 2010 Jun; 4(6): e729.
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2010Phosphoproteome dynamics reveal heat-shock protein complexes specific to the Leishmania donovani infectious stage, Proc. Natl. Acad. Sci. U.S.A. 2010 May;107(18):8381-6.
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2009Leishmania major MPK7 protein kinase activity inhibits intracellular growth of the pathogenic amastigote stage, Eukaryotic Cell 2010 Jan;9(1):22-30.
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2009A dynamic map of antigen recognition by CD4 T cells at the site of Leishmania major infection, Cell Host Microbe 2009 Jul;6(1):23-33.
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2009A novel role for Stat1 in phagosome acidification and natural host resistance to intracellular infection by Leishmania major, PLoS Pathog. 2009 Apr;5(4):e1000381.
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2007Over-expression of Leishmania major MAP kinases reveals stage-specific induction of phosphotransferase activity, Int. J. Parasitol. 2007 Sep;37(11):1187-99.
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2004Identification of a compensatory mutant (lpg2-REV) of Leishmania major able to survive as amastigotes within macrophages without LPG2-dependent glycoconjugates and its significance to virulence and immunization strategies, Infect. Immun. 2004 Jun;72(6):3622-7.
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2004Vaccination with phosphoglycan-deficient Leishmania major protects highly susceptible mice from virulent challenge without inducing a strong Th1 response, J. Immunol. 2004 Mar;172(6):3793-7.
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2000Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major, Proc. Natl. Acad. Sci. U.S.A. 2000 Aug;97(16):9258-63.
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1999Decreased capacity of recombinant 45/47-kDa molecules (Apa) of Mycobacterium tuberculosis to stimulate T lymphocyte responses related to changes in their mannosylation pattern, J. Biol. Chem. 1999 Nov;274(45):32023-30.
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1999Deglycosylation of the 45/47-kilodalton antigen complex of Mycobacterium tuberculosis decreases its capacity to elicit in vivo or in vitro cellular immune responses, Infect. Immun. 1999 Nov;67(11):5567-72.
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