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© A-M. Pais-Correia, M-I. Thoulouze, A. Alcover, A. Gessain
Mise en évidence de structures de type "biofilm ", formées par le rétrovirus HTLV-1 générés par des cellules infectées (cellules du haut), qui ont été transmis à un autre lymphocyte (cellule du bas). Micrographie en microscopie électronique à balayage. Image colorisée.
Starting Date
09
Sep 2015
Status
Ongoing
Members
6
Structures
1

About

Human T-lymphotropic virus type 1 (HTLV-1) is the etiological agent of a slowly progressive neurodegenerative disease, HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). This disease develops upon infiltration of HTLV-1-infected lymphocytes into the central nervous system, mostly at the thoracic spinal cord level. The central nervous system is, in normal condition, protected by a physiological structure called blood-brain barrier (BBB), which is mostly constituted by a continuous endothelium with tight junctions.

We have previously demonstrated that in HAM/TSP patients, the tight junctions of the BBB endothelium are locally disorganized, which allows for T cells transmigration into the CNS and results in a neuroinflammation. Current studies focus on  many factors involved in the interaction of HTLV-1 infected lymphocytes with the BBB endothelium.

Fundings