Synthetic carbohydrate-based conjugates as Shigella vaccine components: design, synthesis, selection and process validation
A synthetic carbohydrate-based conjugate vaccine ready for a clinical trial
Sitting at the frontier between the fields of Chemistry, Glycosciences, and Vaccinology, FlexBiVac is a multidisciplinary project aimed at demonstrating the proof of concept for a new generation of polysaccharide-based multivalent vaccines. The concept […]
At the forefront of the rising fields of Chemical and Synthetic Biology, CarbUniVax is a multidisciplinary project sitting at the frontier between Glycosciences and Vaccinology. A multidisciplinary strategy is proposed that challenges ambitious goals […]
Synthesis of peptide and protein conjugates towards novel therapeutics and/or diagnostic tools
Synthetic peptides and conjugates thereof as potential antivirals (col. H. Lortat-Jacob (CEA, Grenoble), D. Bonnaffé (ICMMO, Orsay) A bi-substrate synthetic glycopeptide resulting from the covalent linkage between a CD4 peptide mimetic and a heparan […]
Carbohydrates as targets of immunity: their synthesis, antibody recognition and use as key vaccine components
Synthetic oligosaccharides are designed and used to identify immunodominant epitopes of bacterial polysaccharide antigens. Conjugates of the most promising oligosaccharides are developed as potential vaccines. Focus is on diarrheal diseases. Shigellosis – bacillary […]
Protected tetrasaccharides, their preparation and their use in the synthesis of bacterial oligosaccharides
2022The First-in-Human Synthetic Glycan-Based Conjugate Vaccine Candidate against Shigella., ACS Cent Sci 2022 Apr; 8(4): 449-460.
2021Safety and immunogenicity of a synthetic carbohydrate conjugate vaccine against Shigella flexneri 2a in healthy adult volunteers: a phase 1, dose-escalating, single-blind, randomised, placebo-controlled study., Lancet Infect Dis 2021 04; 21(4): 546-558.
2021Exploratory N-Protecting Group Manipulation for the Total Synthesis of Zwitterionic Shigella sonnei Oligosaccharides., Chemistry 2021 Mar; 27(18): 5694-5711.
2021Convergent Chemoenzymatic Strategy to Deliver a Diversity of Shigella flexneri Serotype-Specific O-Antigen Segments from a Unique Lightly Protected Tetrasaccharide Core., J Org Chem 2021 Feb; 86(3): 2058-2075.
2021Redirecting substrate regioselectivity using engineered ΔN123-GBD-CD2 branching sucrases for the production of pentasaccharide repeating units of S. flexneri 3a, 4a and 4b haptens., Sci Rep 2021 Jan; 11(1): 2474.
2019Classical and novel strategies to develop a Shigella glycoconjugate vaccine: from concept to efficacy in human., Hum Vaccin Immunother 2019 ; 15(6): 1338-1356.
2018ADP-heptose is a newly identified pathogen-associated molecular pattern of Shigella flexneri., EMBO Rep 2018 12; 19(12): .
2018Bacteriophage Sf6 Tailspike Protein for Detection of Shigella flexneri Pathogens., Viruses 2018 08; 10(8): .
2017Dirhamnolipids secreted from Pseudomonas aeruginosa modify anjpegungal susceptibility of Aspergillus fumigatus by inhibiting β1,3 glucan synthase activity., ISME J 2017 07; 11(7): 1578-1591.
2016Detailed Investigation of the Immunodominant Role of O-Antigen Stoichiometric O-Acetylation as Revealed by Chemical Synthesis, Immunochemistry, Solution Conformation and STD-NMR Spectroscopy for Shigella flexneri 3a, Chemistry 2016 Jul;22(31):10892-911.
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