Link to Pubmed [PMID] – 38088562
Link to DOI – 10.1128/jvi.01351-23
J Virol 2023 Dec; (): e0135123
Our results highlight the plasticity of SARS-CoV-2 Spike to generate highly fusogenic and cytopathic strains with the causative mutations being uncharacterized in previous variants. We describe mechanisms regulating the formation of syncytia and the subsequent consequences in a primary culture model, which are poorly understood.