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© Research
Member: Permanent Researcher

Benjamin Bardiaux

• Structural Bioinformatics

Laboratory: Structural Bioinformatics

About

On the cover: Type IV pili (T4P), long and flexible appendages at the surface of many bacteria, are critical virulence factors. Pili of enterohemorrhagic E. coli (EHEC), an important human pathogen, are polymers of the major subunit PpdD. In the quest for drug and vaccine discovery against such pathogens, unraveling the detailed organization and dynamics of PpdD pili will be instrumental. By combining NMR and cryo-EM, Bardiaux et al. (pp. 1082–1093) add a new page to the coloring book of T4P atomic models. The EHEC T4P structure revealed a large extended region of the pilin stem correlating with extremely high pilus flexibility, along with residues crucial for its assembly and stability. Image created by Benjamin Bardiaux (CNRS/Institut Pasteur, Paris).

Projects

Project
Ongoing
13 Members

OM-LipAsy

Christophe Beloin (PI)

The outer membrane (OM) is an essential element in Gram-negative (diderm) bacteria. Its integrity is maintained by the control of lipids asymmetry via LPS and phospholipids transport by the Lpt and Mla systems, respectively. […]
Project
Ongoing
6 Members

Synergy_T2SS

Olivera Francetic (PI)

Protein secretion in bacteria is highly specific. Substrates secreted via the Type II secretion nanomachines are fully folded prior to secretion and are specifically recognized in their native state. In some cases, they even […]
Project
Ongoing
3 Members

ViBrANT (Viral and Bacterial Adhesin Network Training)

Michael Nilges (PI)

The Innovative Training Network ViBrANT (Viral and Bacterial Adhesin Network Training) brings together world-leading European scientists to train 15 graduate students (early stage researchers) in interdisciplinary research into viral and bacterial adhesins. ViBrANT is […]
Project
Ongoing
4 Members

ARIA for hybrid structure determination on the cloud

Benjamin Bardiaux (PI)

Protein structure determination is crucial for understanding protein function, as it paves the way to the discovery of new drugs and of new approaches to control pathological biological processes. The recent advances in structural […]
Project
Ongoing
9 Members

ERC-2011-AdG BAYCELLS

Michael Nilges (PI)

A Bayesian Framework for Cellular Structural Biology Objective : “The functioning of a single cell or organism is governed by the laws of chemistry and physics. The bridge from biology to chemistry and physics […]
Project
Ongoing
20 Members

Bip:Bip

Michael Nilges (PI)

About Bip:Bip The project Bip:Bip promotes an integrated use of known and modelled three-dimensional structures of proteins as an aid in complete genome annotation. The architectural organization of biological macromolecules is essential for the […]
Project
Ongoing
7 Members

Bacterial Transmembrane Signaling

Nadia Izadi-Pruneyre (PI)

Bacteria display several mechanisms to adapt to their host-environment and successfully colonise it. One important mechanism of adaptation concerns the regulation of gene expression in response to external signals such as the presence of […]

CV

Since Dec 2012, permanent research associate at CNRS UMR3528 and Unité de Bioinformatique Structurale.

Publications

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