On the cover: Type IV pili (T4P), long and flexible appendages at the surface of many bacteria, are critical virulence factors. Pili of enterohemorrhagic E. coli (EHEC), an important human pathogen, are polymers of the major subunit PpdD. In the quest for drug and vaccine discovery against such pathogens, unraveling the detailed organization and dynamics of PpdD pili will be instrumental. By combining NMR and cryo-EM, Bardiaux et al. (pp. 1082–1093) add a new page to the coloring book of T4P atomic models. The EHEC T4P structure revealed a large extended region of the pilin stem correlating with extremely high pilus flexibility, along with residues crucial for its assembly and stability. Image created by Benjamin Bardiaux (CNRS/Institut Pasteur, Paris).
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Since Dec 2012, permanent research associate at CNRS UMR3528 and Unité de Bioinformatique Structurale.
Publications
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2021Characterization of the interaction domains between the phosphoprotein and the nucleoprotein of human Metapneumovirus., J Virol 2021 Nov; (): JVI0090921.
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20211 H, 15 N and 13 C resonance assignments of the C-terminal domain of PulL, a component of the Klebsiella oxytoca type II secretion system, Biomol NMR Assign . 2021 Oct;15(2):455-459. .
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2021Computational and biochemical analysis of type IV pilus dynamics and stability., Structure 2021 Sep; (): .
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20211H, 15 N and 13C resonance assignments of the C-terminal domain of PulL, a component of the Klebsiella oxytoca type II secretion system., Biomol NMR Assign 2021 Aug; (): .
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2021A Structural and Dynamic Analysis of the Partially Disordered Polymerase-Binding Domain in RSV Phosphoprotein., Biomolecules 2021 Aug; 11(8): .
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2021Host-Pathogen Adhesion as the Basis of Innovative Diagnostics for Emerging Pathogens., Diagnostics (Basel) 2021 Jul; 11(7): .
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2021Structural and molecular basis of cross-seeding barriers in amyloids., Proc Natl Acad Sci U S A 2021 Jan; 118(1): .
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2021Structures of Pathological and Functional Amyloids and Prions, a Solid-State NMR Perspective., Front Mol Neurosci 2021 ; 14(): 670513.
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2020Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage., Nat Commun 2020 Jun; 11(1): 3014.
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2020ARIAweb: a server for automated NMR structure calculation., Nucleic Acids Res. 2020 May; (): .
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