On the cover: Type IV pili (T4P), long and flexible appendages at the surface of many bacteria, are critical virulence factors. Pili of enterohemorrhagic E. coli (EHEC), an important human pathogen, are polymers of the major subunit PpdD. In the quest for drug and vaccine discovery against such pathogens, unraveling the detailed organization and dynamics of PpdD pili will be instrumental. By combining NMR and cryo-EM, Bardiaux et al. (pp. 1082–1093) add a new page to the coloring book of T4P atomic models. The EHEC T4P structure revealed a large extended region of the pilin stem correlating with extremely high pilus flexibility, along with residues crucial for its assembly and stability. Image created by Benjamin Bardiaux (CNRS/Institut Pasteur, Paris).
The outer membrane (OM) is an essential element in Gram-negative (diderm) bacteria. Its integrity is maintained by the control of lipids asymmetry via LPS and phospholipids transport by the Lpt and Mla systems, respectively. […]
Protein secretion in bacteria is highly specific. Substrates secreted via the Type II secretion nanomachines are fully folded prior to secretion and are specifically recognized in their native state. In some cases, they even […]
ViBrANT (Viral and Bacterial Adhesin Network Training)
The Innovative Training Network ViBrANT (Viral and Bacterial Adhesin Network Training) brings together world-leading European scientists to train 15 graduate students (early stage researchers) in interdisciplinary research into viral and bacterial adhesins. ViBrANT is […]
ARIA for hybrid structure determination on the cloud
Protein structure determination is crucial for understanding protein function, as it paves the way to the discovery of new drugs and of new approaches to control pathological biological processes. The recent advances in structural […]
A Bayesian Framework for Cellular Structural Biology Objective : “The functioning of a single cell or organism is governed by the laws of chemistry and physics. The bridge from biology to chemistry and physics […]
About Bip:Bip The project Bip:Bip promotes an integrated use of known and modelled three-dimensional structures of proteins as an aid in complete genome annotation. The architectural organization of biological macromolecules is essential for the […]
Bacterial Transmembrane Signaling
Bacteria display several mechanisms to adapt to their host-environment and successfully colonise it. One important mechanism of adaptation concerns the regulation of gene expression in response to external signals such as the presence of […]
ARIA (Ambiguous Restraints for Iterative Assignment)
Our computer program ARIA (Ambiguous Restraints for Iterative Assignment) is a software for automated NOE assignment and NMR structure calculation. It speeds up and automatizes the assignment process through the use of an iterative […]
ARIAweb: a server for automated NMR structure calculation
The ARIAweb server provides access to the main ARIA software functionalities (NMR data conversion and structure calculation). In addition, structure calculation results can be easily visualised, with a dedicated molecular viewer and graphical displays […]
Since Dec 2012, permanent research associate at CNRS UMR3528 and Unité de Bioinformatique Structurale.
2021Computational and biochemical analysis of type IV pilus dynamics and stability., Structure 2021 Sep; (): .
20211H, 15 N and 13C resonance assignments of the C-terminal domain of PulL, a component of the Klebsiella oxytoca type II secretion system., Biomol NMR Assign 2021 Aug; (): .
2021A Structural and Dynamic Analysis of the Partially Disordered Polymerase-Binding Domain in RSV Phosphoprotein., Biomolecules 2021 Aug; 11(8): .
2021Host-Pathogen Adhesion as the Basis of Innovative Diagnostics for Emerging Pathogens., Diagnostics (Basel) 2021 Jul; 11(7): .
2021Structural and molecular basis of cross-seeding barriers in amyloids., Proc Natl Acad Sci U S A 2021 Jan; 118(1): .
2021Structures of Pathological and Functional Amyloids and Prions, a Solid-State NMR Perspective., Front Mol Neurosci 2021 ; 14(): 670513.
2020Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage., Nat Commun 2020 Jun; 11(1): 3014.
2020ARIAweb: a server for automated NMR structure calculation., Nucleic Acids Res. 2020 May; (): .
2019Structure and function of minor pilins of type IV pili, Med. Microbiol. Immunol. 2019 Nov;.
2019Quantitative Structural Interpretation of Protein Crosslinks, Structure 2019 Nov;.
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