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© Research
Event

Department of Structural Biology and Chemistry seminar: Dr. Pablo Chacon, Fitting tools for integrative structural biology

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
19
Sep 2019
Time
14:00:00
28 Rue du Dr Roux, Paris, France
Address
Building: François Jacob Room: Auditorium François Jacob
Location
2019-09-19 14:00:00 2019-09-19 15:30:00 Europe/Paris Department of Structural Biology and Chemistry seminar: Dr. Pablo Chacon, Fitting tools for integrative structural biology Department of Structural Biology & Chemistry seminar Tuesday 17 september 2019 at 2.00 pm AUDITORIUM CENTRE F. JACOB – CFJ RdC 17c Dr. Pablo Chacon Biological Chemical Physics Department Rocasolano Physical Chemistry Institute (IQFR), […] 28 Rue du Dr Roux, Paris, France Benjamin Bardiaux benjamin.bardiaux@pasteur.fr

About

Department of Structural Biology & Chemistry seminar
Tuesday 17 september 2019 at 2.00 pm
AUDITORIUM CENTRE F. JACOB – CFJ RdC 17c

Dr. Pablo Chacon

Biological Chemical Physics Department
Rocasolano Physical Chemistry Institute (IQFR), Spain

 

Fitting tools for integrative structural biology
Modeling cryo-electron microscopy (cryo-EM) reconstructions with computational tools currently enables the interpretation at near-atomic resolution of different functional states of macromolecules, thereby deciphering the functional mechanism of biologically relevant complexes. I will briefly describe the computational algorithms developed by us to build macromolecular models from the information encoded into cryo-EM density maps (see  http://chaconlab.org/methods-bioinformatics-tools). Then, examples of rigid-body or flexible fitting of the available atomic models into selected experimental maps will demonstrate the power of our methodology. These examples include the reconstruction of NAIP5-NLRC4 inflammasome complex and its activation by the bacterial flagellin.

 

Contact : Benjamin Bardiaux
Unité Bio-informatique Structurale
Benjamin.bardiaux@pasteur.fr

 

 

 

 

Location

Building: François Jacob
Room: Auditorium François Jacob
Address: 28 Rue du Dr Roux, Paris, France