Dr. Caroline Passaes received her Master’s degree in Parasite Biology in 2007 from the Oswaldo Cruz Foundation, Brazil, the largest institution for research and development in biomedical sciences in South America. Since 2005, she has been working on HIV research. During her MSc, she performed studies on the molecular epidemiology of HIV in Brazil. In 2012, she received her PhD in Parasite Biology from the same institution. During her PhD, she investigated the HIV integrase and if the integration process could be impaired in patients with different clinical courses of HIV infection, with focus on individuals that naturally control HIV infection. During this time, she had the opportunity to join the group headed by Dr Mario Stevenson at the University of Miami, from June to October 2011, where she worked on HIV reservoirs and gene expression of cellular co-factors which are part of the integration process in a cohort of HIV controllers. In 2012, she was a visiting researcher at Oswaldo Cruz Institute to develop a project on viral proteins and host restrictions factors in HIV controllers patients. From November 2012 to November 2015 she worked as a post-doctoral fellow at the Institut Pasteur and at the Commissariat à l’énergie atomique et aux énergies alternatives (CEA), to develop a project focused on the analyses of early steps leading to long term control of SIV infection. She is currently developing studies of immunoregulation in non-human primate models of natural (SIV controllers) and post-treatment controllers (pVISCONTI).
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Natural Control of HIV-1 Infection
Asier Sáez-Cirión (PI)
HIV-controllers (HIC) (also called “elite controllers” or “elite suppressors”) are rare (less than 1%) HIV-infected patients who control viral replication to undetectable levels in the absence of antiretroviral treatment. In the context of the […]
2021Ultrasensitive detection of p24 in plasma samples from people with primary and chronic HIV-1 infection., J Virol 2021 May; (): .
2021SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity., Nat Commun 2021 02; 12(1): 1282.
2021CD32+CD4+ T Cells Sharing B Cell Properties Increase With Simian Immunodeficiency Virus Replication in Lymphoid Tissues., Front Immunol 2021 ; 12(): 695148.
2020Optimal Maturation of the SIV-Specific CD8+ T Cell Response after Primary Infection Is Associated with Natural Control of SIV: ANRS SIC Study., Cell Rep 2020 09; 32(12): 108174.
2020The genome-wide methylation profile of CD4+ T cells from HIV-infected individuals identifies distinct patterns associated with disease progression., Clin Infect Dis 2020 Jul; (): .
2020Antiapoptotic Clone 11-Derived Peptides Induce In Vitro Death of CD4+ T Cells Susceptible to HIV-1 Infection., J Virol 2020 07; 94(14): .
2020TLR7 dosage polymorphism shapes interferogenesis and HIV-1 acute viremia in women., JCI Insight 2020 06; 5(12): .
2020Vulnerability to reservoir reseeding due to high immune activation after allogeneic hematopoietic stem cell transplantation in individuals with HIV-1., Sci Transl Med 2020 05; 12(542): .
2019Metabolic plasticity of HIV-specific CD8+ T cells is associated with enhanced antiviral potential and natural control of HIV-1 infection., Nat Metab 2019 07; 1(7): 704-716.
2019Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4+ T Cells and Offers an Opportunity to Tackle Infection., Cell Metab 2019 03; 29(3): 611-626.e5.
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