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About

Dr. Caroline Passaes received her Master’s degree in Parasite Biology in 2007 from the Oswaldo Cruz Foundation, Brazil, the largest institution for research and development in biomedical sciences in South America. Since 2005, she has been working on HIV research. During her MSc, she performed studies on the molecular epidemiology of HIV in Brazil. In 2012, she received her PhD in Parasite Biology from the same institution. During her PhD, she investigated the HIV integrase and if the integration process could be impaired in patients with different clinical courses of HIV infection, with focus on individuals that naturally control HIV infection. During this time, she had the opportunity to join the group headed by Dr Mario Stevenson at the University of Miami, from June to October 2011, where she worked on HIV reservoirs and gene expression of cellular co-factors which are part of the integration process in a cohort of HIV controllers. In 2012, she was a visiting researcher at Oswaldo Cruz Institute to develop a project on viral proteins and host restrictions factors in HIV controllers patients. From November 2012 to November 2015 she worked as a post-doctoral fellow at the Institut Pasteur and at the Commissariat à l’énergie atomique et aux énergies alternatives (CEA), to develop a project focused on the analyses of early steps leading to long term control of SIV infection. She is currently developing studies of immunoregulation in non-human primate models of natural (SIV controllers) and post-treatment controllers (pVISCONTI).

CV

Education
03/2008 – 02/2012 
PhD in Parasite Biology (Virology/Immunology)

“Studies about viral and genetic aspects related to integrase and to the integration process in individuals with different clinical courses of HIV-1 infection”

Supervision : Dr Mariza Gonçalves Morgado/Dr Mario Stevenson

 
 Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilMiller School of Medicine, University of Miami, Miami, USA (June to October/2011) 
09/2007 – 11/2009
Training in Bioscience and Health Education
Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
03/2005 to 04/2007
MSc in Parasite Biology (Virology/Genetics)

“Molecular characterization of integrase region of pol gene in HIV-1 subtypes prevalent in Brazil: evaluation of resistance and antigenic markers”

Supervision : Dr Mariza Gonçalves Morgado

Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil 
08/2001 to 02/2005
BSc Biology

“Topical anti-inflammatory activity of Aqueous Extract of Baccharis trimera and its fractions”.

Supervision: Dr. Marsen Garcia Pinto Coelho

Department of Biochemistry, Institute of Biology Roberto Alcântara Gomes, University of State of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil

Positions and professional experience

Since 04/2018
Research Engineer (Pasteur Institute)
 
Group Viral reservoirs and controlUnité HIV, inflammation et persistance, Institut Pasteur, Paris, France
 
 
11/2015 – 03/2018
Postdoctoral research fellow (ANRS/MSDAVENIR)

“p(rimate)-VISCONTI study – A Non-Human Primate Model For HIV Remission”

Supervision : Dr Asier Saez Cirion

 
Unité HIV, inflammation et persistance, Institut Pasteur, Paris, France 
11/2012  – 11/2015
Postdoctoral research fellow (ANRS)

“SIVmac/cynomolgus macaque models to analyze early steps leading to long term control of SIV infection”

Supervision : Dr Asier Saez Cirion/Dr Bruno Vaslin

 
Unité HIV, inflammation et persistance, Institut Pasteur, Paris, FranceUnité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, FranceService d’Immuno Virologie, Commissariat à l’énergie atomique et aux énergies alternatives, Fontenay aux Roses, France  
02/2012 – 11/2012
Visiting researcher fellow (CNPq)

“Functional study of viral proteins and host restrictions factors in HIV-controllers patients”

Supervision : Dr Mariza Gonçalves Morgado

Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

Publications

  1. TLR7 dosage polymorphism shapes interferogenesis and HIV-1 acute viremia in women. Pascal Azar, José E. Mejía, Claire Cenac, Arnoo Shaiykova, Ali Youness, Sophie Laffont, Asma Essat, Jacques Izopet, Caroline Passaes, Michaela Muller-Trutwin, Pierre Delobel, Laurence Meyer, Jean-Charles Guéry. Accepted JCI.
  2. Priming of de novo HIV-specific CD8+T-cell responses and incomplete T-cell reconstitution in HIV-1 infected individuals after allo-HSCT. Johanna M. Eberhard, Mathieu Angin, Caroline Passaes, Maria Salgado, Valerie Monceaux, Björn Jensen, Elena Knops, Maximilian Christopeit, Nicolaus Kröger, Linos Vandekerckhove, Jon Badiola, Alessandra Bandera, Kavita Raj, Jan van Lunzen, Gero Hütter, Vanderson Rocha, Jürgen H.E. Kuball, Pascual Balsalobre, Mi Kwon, José L. Díez Martín, Monique Nijhuis, Annemarie Wensing, Javier Martinez-Picado, Julian Schulze zur Wiesch, Asier Sáez-Cirión. Science Translational Medicine 2020.
  3. Anti-apoptotic clone 11 derived peptides induce in vitro death of CD4+ T cells susceptible to HIV-1 infection. Mikhailova A, Valle-Casuso JC, David A, Monceaux V, Volant S, Passaes C, Elfidha A, Müller-Trutwin M, Poyet JL, Sáez-Cirión A. J Virol 2020 Apr 29.
  4. Metabolic plasticity of HIV-specific CD8+ T cells is associated with enhanced antiviral potential and natural control of HIV-1 infection. Mathieu Angin, Stevenn Volant, Caroline Passaes, Camille Lecuroux, Valérie Monceaux, Marie-Agnès Dillies, José Carlos Valle-Casuso, Gianfranco Pancino, Bruno Vaslin, Roger Le Grand, Laurence Weiss, Cecile Goujard, Laurence Meyer, Faroudy Boufassa, Michaela Müller-Trutwin, Olivier Lambotte & Asier Sáez-Cirión. Nature Metabolism 2019 Jul 1; 704–716
  5. Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4+ T Cells and Offers an Opportunity to Tackle Infection. Valle-Casuso JC, Angin M, Volant S, Passaes C, Monceaux V, Mikhailova A, Bourdic K, Avettand-Fenoel V, Boufassa F, Sitbon M, Lambotte O, Thoulouze MI, Müller-Trutwin M, Chomont N, Sáez-Cirión A. Cell Metab. 2018 Dec 19. pii: S1550-4131(18)30734-4.
  6. Stage-specific IFN-induced and IFN gene expression reveal convergence of type I and type II IFN and highlight their role in both acute and chronic stage of pathogenic SIV infection. Echebli N, Tchitchek N, Dupuy S, Bruel T, Passaes C, Bosquet N, Le Grand R, Bourgeois C, Favier B, Cheynier R, Lambotte O, Vaslin B. PLoS One. 2018 Jan 11;13(1):e0190334.
  7. Ultrasensitive HIV-1 p24 detects single infected cells and differences in reservoir induction by latency-reversal agents. Caroline Pereira-Bittencourt Passaes, Timothée Bruel, Jeremie Decalf, Annie David, Mathieu Angin, Valerie Monceaux, Michaela Muller-Trutwin, Nicolas Noel, Katia Bourdic, Olivier Lambotte, Matthew Albert, Darragh Duffy, Olivier Schwartz, Asier Sáez-Cirión, and ANRS ANRS RHIVIERA consortium. J Virol. 2017 Feb 28;91(6).
  8. Elevated pre-infection CXCL10 in plasma and in the small intestine after infection are associated with more rapid HIV/SIV disease onset. Mickaël J. Ploquin, Yoann Madec, Armanda Casrouge, Nicolas Huot, Caroline Passaes, Camille Lécuroux, Asma Essat, Faroudy Boufassa, Béatrice Jacquelin, Simon P. Jochems, Gaël Petitjean, Mathieu Angin, Kathleen Gärtner, Thalía Garcia-Tellez, Nicolas Noël, Thijs Booiman, Brigitte D. Boeser-Nunnink, Pierre Roques, Asier Saez-Cirion, Bruno Vaslin, Nathalie Dereudre-Bosquet, Françoise Barré-Sinoussi, Mathilde Ghislain, Christine Rouzioux, Olivier Lambotte, Matthew L. Albert, Cécile Goujard, Neeltje Kootstra, Laurence Meyer, Michaela C. Müller-Trutwin. PLoS Pathog. 2016 Aug 10;12(8):e1005774.
  9. HIV controllers with different viral load cut-off levels have distinct virologic and immunologic profiles. Côrtes FH, Passaes CP, Bello G, Teixeira SL, Vorsatz C, Babic D, Sharkey M, Grinsztejn B, Veloso V, Stevenson M, Morgado MG. J Acquir Immune Defic Syndr. 2015 Apr 1;68(4):377-85.
  10. Association of single nucleotide polymorphisms in the lens epithelium-derived growth factor (LEDGF/p75) with HIV-1 infection outcomes in Brazilian HIV-1+ individuals. Passaes, CP, Cardoso, CC, Caetano, DG, Teixeira, SL, Guimarães, ML, Campos, DP, Veloso, VG, Babic, D, Stevenson, M; Moraes, MO, Morgado, MG. PLoS One. 2014 Jul 21;9(7).
  11. HIV cure research: advances and prospects. Passaes CP, Sáez-Cirión A. Virology. 2014 Apr;454-455:340-52.
  12. Temporal dynamics of HIV-1 circulating subtypes in distinct exposure categories in southern Brazil. Almeida SE, de Medeiros RM, Junqueira DM, Gräf T, Passaes CP, Bello G, Morgado MG, L Guimarães M. Virol J. 2012 Dec 12;9:306.
  13. Monitoring the emergence of resistance mutations in patients infected with HIV-1 under salvage therapy with raltegravir in Rio de Janeiro, Brazil: a follow-up study. Passaes CP, Guimarães ML, Cardoso SW, Pilotto JH, Veloso V, Grinsztejn B, Morgado MG. J Med Virol. 2012 Dec;84(12):1869-75.
  14. HIV-1 genetic diversity and drug resistance among treatment naïve patients from Southern Brazil: an association of HIV-1 subtypes with exposure categories. Gräf T, Passaes CP, Ferreira LG, Grisard EC, Morgado MG, Bello G, Pinto AR. J Clin Virol. 2011 Jul;51(3):186-91.
  15. The nerve growth factor reduces APOBEC3G synthesis and enhances HIV-1 transcription and replication in human primary macrophages. Souza TM, Rodrigues DQ, Passaes CP, Barreto-de-Souza V, Aguiar RS, Temerozo JR, Morgado MG, Fontes CF, Araujo EG, Bou-Habib DC. Blood. 2011 Mar 10;117(10):2944-52.
  16. Near full-length genome characterization of HIV type 1 unique BC recombinant forms from Southern Brazil. Passaes CP, Guimarães ML, Bello G, Morgado MG. AIDS Res Hum Retroviruses. 2009 Dec;25(12):1339-44.
  17. Evidences of recent decline in the expansion rate of the HIV type 1 subtype C and CRF31_BC epidemics in southern Brazil. Bello G, Guimarães ML, Passaes CP, Matos Almeida SE, Veloso VG, Morgado MG. AIDS Res Hum Retroviruses. 2009 Nov;25(11):1065-9.
  18. Genetic characterization of HIV-1 BC recombinants and evolutionary history of the CRF31_BC in Southern Brazil. Passaes CP, Bello G, Lorete RS, Matos Almeida SE, Junqueira DM, Veloso VG, Morgado MG, Guimarães ML. Infect Genet Evol. 2009 Jul;9(4):474-82.
  19. Lack of primary mutations associated with integrase inhibitors among HIV-1 subtypes B, C, and F circulating in Brazil. Passaes CB, Guimarães ML, Fernandez SL, Lorete Rdos S, Teixeira SL, Fernandez JC, Morgado MG. J Acquir Immune Defic Syndr. 2009 May 1;51(1):7-12.
  20. Origin and evolutionary history of HIV-1 subtype C in Brazil. Bello G, Passaes CP, Guimarães ML, Lorete RS, Matos Almeida SE, Medeiros RM, Alencastro PR, Morgado MG. AIDS. 2008 Oct 1;22(15):1993-2000.
  21. Acute and topic anti-edematogenic fractions isolated from the seeds of Pterodon pubescens. Silva MC, Gayer CR, Lopes CS, Calixto NO, Reis PA, Passaes CP, Paes MC, Dalmau SR, Sabino KC, Todeschini AR, Coelho MG. J Pharm Pharmacol. 2004 Jan;56(1):135-41.

Book chapters

1.     Avoiding AIDS Armageddon: How Antiretroviral Therapy Turned the Tide of the HIV Pandemic.

Chapter 42: Aiming for HIV Elimination, Planning for Eradication – The Role of an HIV Vaccine and/or Cure.

Caroline Passaes, Asier Saez-Cirion

Oxford University Press, 2020

 

Invited speaker

1.     Animal Models of Spontaneous Control: Lessons Learned and Future Directions. Keystone Symposia Mechanisms of HIV Persistence: Implications for a Cure. Boston, USA, April 2015.

Oral presentation

1.     3ème Journée Scientifique MSDAVENIR. Etude pVISCONTI: Rémission et VIH. Paris, France, November 2019.

2.     Early anti-SIV CD8+ T-cell antiviral activity is associated with durable elite control of SIV infection in macaques carrying or not protective MHC alleles – the ANRS SIC study. IAS Conference 2017, Paris, France, July 2017.

3.     Early anti-SIV CD8+ T-cell antiviral activity is associated with durable elite control of SIV infection in macaques carrying or not protective MHC alleles – the ANRS SIC study. Journées Departamentales de Immunologie, Institut Pasteur, Morzine, France, May 2017.

4.     Ultrasensitive detection of HIV Gag p24 protein at the single cell level in culture and in patient samples. ANRS AC32 Meeting. Paris, France, May 2016.

5.     Role of CD8+ T Cells during acute infection in cynomolgus macaques controlling SIV replication. 32nd Annual Symposium on Nonhuman Primate Models for AIDS. Portland, USA, November 2014.

6.     Role of CD8+ T cells during acute infection in cynomolgus macaques controlling SIV replication. ANRS & IDMIT NHP Meeting. Paris, France, June 2014.

7.     Monitoring the emergence of resistance mutations in patients under salvage therapy with Raltegravir in Rio de Janeiro, Brazil: a six month follow-up. AIDS 2010. Vienna, Austria, July 2010.

8.     Trends of integrase inhibitors drug resistance in treatment-naive patients with HIV-1 subtype C infection in Brazil. AIDS 2008. Mexico City, México, August 2008.

9.     Naturally occurring integrase polymorphisms in HIV-1 subtypes B, C and F prevalent in Brazil: impact for drug resistance. XVII National Virology Meeting. Campos do Jordão, Brazil, November 2006.

10.  Genetic diversity of integrase in HIV-1 subtypes B, F and C prevalent in Brazil: Study in drug naive and multidrug resistant individuals reveals impact for drug resistance. Advanced Seminary on HIV/AIDS Pathogenesis. Rio de Janeiro, Brazil, October 2006.

Reviewer

Virology
Journal of Medical Virology (ISSN: 1096-9071)

Intervirology (ISSN: 0300-5526)

BioMed Research International (ISSN: 2314-6133)

PlosOne (ISSN: 1932-6203)

Viruses (ISSN 1999-4915)

Immunology
PlosOne (ISSN: 1932-6203)

Vaccines (ISSN 2076-393X) – Guest editor Special issue: Non-human primate research in immune modulation and drug discovery

 

Genetics

 

Infection, Genetics and Evolution (ISSN: 1567-1348)

Viruses (ISSN 1999-4915)

Mediators of inflammation (ISSN: 0962-9351) – Guest editor Special issue: Genetics of Infectious Diseases and Immunoinflammatory Disorders

Inventions & Patents

2019
Metabolic reprogramming of cell responses to counteract HIV infection

SAEZ-CIRION, A ; ANGIN, M ; PASSAES, C; MÜLLER-TRUTWIN, M.Unité HIV, inflammation et persistance, Institut Pasteur, Paris, France

2018
Development of a method for immune complex dissociation in plasma samples compatible with the technology Simoa® by Quanterix Corporation

PASSAES, C; DAVID A.; DUFFY D.; SAEZ-CIRION A. Unité HIV, inflammation et persistance, Institut Pasteur, Paris, France 

2018
Development of a custom non-human primate kit for negative selection of NK cells; in partnership with Miltenyi Biotec

PASSAES, C; DAVID A.; SAEZ-CIRION A. Unité HIV, inflammation et persistance, Institut Pasteur, Paris, France 

2005
HIV integrase genotyping

PASSAES, C; DELATORRE E.; GUIMARAES M.; MORGADO M. Laboratory of AIDS and Molecular Immunology, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

Teaching

2010
Lecture in Molecular characterization of viruses

“Methodologies applied to the study of viral infections”

Public: undergraduate students

Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

2008
Lecture in Molecular Biology

“Blood bank and Hemotherapy”

Public: post-graduation students

Faculdades Integradas Maria Thereza (FAMATh), Niteroi, Brazil

Prize & Fellowship

2017
Scholarship recipient – IAS Conference 2017, International AIDS Society
2014
Travel Award – NHP2014, Oregon National Primate Research Center (ONPRC)
2013
Honorable Mention at the Thesis Award of the Coordination for the Improvement of Higher Level Personnel (CAPES), Brazilian Ministry of Education (ranked second)
2013
Annual Thesis Award Alexandre Peixoto, Oswaldo Cruz Institute, Brazil
2012
Scholarship recipient – Conference on Retroviruses and Opportunistic Infections, CROI 2012
2010
FAPERJ NOTA 10 fellowship (fellowship granted to the student with the most relevant academic activity in the Ph.D. program)
2010
“Towards a Cure”: HIV Reservoirs and Strategies to Control Them Workshop, 2010, Vienna, Austria (Sidaction fellowship).
2010
Scholarship recipient – AIDS 2010, International AIDS Society
2008
Scholarship recipient – AIDS 2008, International AIDS Society
2007
Honorable mention in the Incentive in Science and Technology for SUS Award, Brazilian Ministry of Health
2007
Scholarship recipient – AIDS Vaccine 2007, Global HIV Vaccine Enterprise
2005
Best scientific work – Master’s Degree – in IX Post Graduation Scientific Journey – Oswaldo Cruz Foundation.

Publications

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