Dr. Caroline Passaes received her Master’s degree in Parasite Biology in 2007 from the Oswaldo Cruz Foundation, Brazil, the largest institution for research and development in biomedical sciences in South America. Since 2005, she has been working on HIV research. During her MSc, she performed studies on the molecular epidemiology of HIV in Brazil. In 2012, she received her PhD in Parasite Biology from the same institution. During her PhD, she investigated the HIV integrase and if the integration process could be impaired in patients with different clinical courses of HIV infection, with focus on individuals that naturally control HIV infection. During this time, she had the opportunity to join the group headed by Dr Mario Stevenson at the University of Miami, from June to October 2011, where she worked on HIV reservoirs and gene expression of cellular co-factors which are part of the integration process in a cohort of HIV controllers. In 2012, she was a visiting researcher at Oswaldo Cruz Institute to develop a project on viral proteins and host restrictions factors in HIV controllers patients. From November 2012 to November 2015 she worked as a post-doctoral fellow at the Institut Pasteur and at the Commissariat à l’énergie atomique et aux énergies alternatives (CEA), to develop a project focused on the analyses of early steps leading to long term control of SIV infection. She is currently developing studies of immunoregulation in non-human primate models of natural (SIV controllers) and post-treatment controllers (pVISCONTI).
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Natural Control of HIV-1 Infection
Asier Sáez-Cirión (PI)
HIV-controllers (HIC) (also called “elite controllers” or “elite suppressors”) are rare (less than 1%) HIV-infected patients who control viral replication to undetectable levels in the absence of antiretroviral treatment. In the context of the […]
2019Metabolic plasticity of HIV-specific CD8+ T cells is associated with enhanced antiviral potential and natural control of HIV-1 infection, Nat Metab 1, 704–716 (2019).
2018Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4 T Cells and Offers an Opportunity to Tackle Infection, Cell Metab. 2018 Dec;.
2018Stage-specific IFN-induced and IFN gene expression reveal convergence of type I and type II IFN and highlight their role in both acute and chronic stage of pathogenic SIV infection., PLoS One. 2018 Feb 23;13(2):e0193629..
2017Ultrasensitive HIV-1 p24 Assay Detects Single Infected Cells and Differences in Reservoir Induction by Latency Reversal Agents, J. Virol. 2017 03;91(6).
2016Elevated Basal Pre-infection CXCL10 in Plasma and in the Small Intestine after Infection Are Associated with More Rapid HIV/SIV Disease Onset, PLoS Pathog. 2016 Aug;12(8):e1005774.
2015HIV controllers with different viral load cutoff levels have distinct virologic and immunologic profiles, J. Acquir. Immune Defic. Syndr. 2015 Apr;68(4):377-85.
2014Association of single nucleotide polymorphisms in the lens epithelium-derived growth factor (LEDGF/p75) with HIV-1 infection outcomes in Brazilian HIV-1+ individuals, PLoS ONE 2014;9(7):e101780.
2014HIV cure research: advances and prospects, Virology 2014 Apr;454-455:340-52.
2012Temporal dynamics of HIV-1 circulating subtypes in distinct exposure categories in southern Brazil, Virol. J. 2012;9:306.
2012Monitoring the emergence of resistance mutations in patients infected with HIV-1 under salvage therapy with raltegravir in Rio de Janeiro, Brazil: a follow-up study, J. Med. Virol. 2012 Dec;84(12):1869-75.
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