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  • Associate Professor
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  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
20
Apr 2017
Ending Date
30
Apr 2019
Status
Ongoing
Members
4
Structures
3

About

Protein structure determination is crucial for understanding protein function, as it paves the way to the discovery of new drugs and of new approaches to control pathological biological processes. The recent advances in structural biology now allow collecting structural information from a variety of techniques at various resolutions. Integration of such heterogeneous data to determine hybrid structure is currently a computational challenge in molecular modelling, both in term of computing efficiency and availability of bioinformatics tools. The widely used ARIA software developed at Institut Pasteur has proven very efficient in automatically determining protein structures from NMR data. In this project, we will expand the repertoire of input data types that can be used with ARIA for hybrid structure determination. In parallel, it is necessary to bridge the data analysis modules of ARIA with other relevant structure generation engines to be able to analyse the data types. To ultimately provide a perfectly transparent service to the end user, we will design a web-interface for ARIA and make hybridARIA freely available for the scientific community, notably through the cloud deployed by IFB.

Fundings