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About

The objective of my research is to understand the function of complex biological systems and to unravel the basis of the molecular mechanisms by which such functions are achieved. Most biological systems – if not all – do not behave like solid rocks, but they are in fact dynamical objects that interconvert among several different conformational states. In many cases, a specific function is achieved by an interplay between structural and dynamical properties of the system. As a consequence, understanding the behaviour of biological systems requires the determination of a structural ensemble (A), defined by the structures of all the relevant states that these molecules can occupy, their populations, and the rates of interconversion among these states. This goal can be effectively achieved by using integrative approaches that combine experimental and computational techniques (B).

My research  at Institut Pasteur is focused on the development of integrative modelling approaches for the determination of protein structural ensembles and their application to systems of outstanding biological importance. A recent field of application is the simultaneous determination of protein structure and dynamics by integrating cryo-electron microscopy data with other sources of theoretical and experimental information (C).

Relevant bibliography

  • M. Bonomi, M. Vendruscolo. Curr. Opin. Struct. Biol. 56 (2019) 37.
  • M. Bonomi, R. Pellarin, M. Vendruscolo. Biophys. J. 114 (2018) 1604.
  • S. Vahidi et al. Proc. Natl. Acad. Sci. USA 115 (2018) E6447.
  • M. Bonomi, G. Heller, C. Camilloni, M. Vendruscolo. Curr. Opin. Struct. Biol. 42 (2017) 106.
  • M. Bonomi, C. Camilloni. Bioinformatics 33 (2017) 3999.
  • M. Bonomi, C. Camilloni, A. Cavalli, M. Vendruscolo. Sci. Adv. 2 (2016) e1501177.
  • G. Tribello, M. Bonomi, D. Branduardi, C. Camilloni, G. Bussi. Comp. Phys. Comm. 185 (2014) 604.

Software

CV

Professional experience

  • 2018-Present: Institut Pasteur and CNRS, Chargé de recherche de classe normal
  • 2013-2018: University of Cambridge, Postdoc – Vendruscolo group
  • 2014-2016: University of Washington, Consultant
  • 2010-2013: University of California San Francisco, Postdoc – Sali group
Education

  • 2006-2010: ETH Zurich, Ph.D. – Parrinello Group
  • 1998-2004: Universitá degli Studi di Milano – M.Sc. in Theoretical Physics
Full CV available here (updated March 2019)

Publications

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