Timeline

Paola Arimondo

Head of Structure

05 Nov 2024

publication

Supercomputer-based virtual screening for DNMT1 inhibitors as novel anticancer agents

01 Oct 2024

event

3rd PPU Oxford bilateral summit “Chimie Biologique” – “Tackling AntiMicrobial Resistance, together”

27 Sep 2024

event

Thesis defense – Synthesis and identification of chemical compounds targeting DNA Methylation reader proteins (By Jean Contreras)

18 Apr 2024

publication

Adenine, a key player in biology and medicinal chemistry

12 Apr 2024

event

Call for abstracts & Register ! “Tackling antibacterial and antifungal resistant infections from disease to innovative therapies” – an international AMR symposium

05 Apr 2024

publication

Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells

05 Apr 2024

publication

Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells

01 Apr 2024

publication

Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization.

20 Feb 2024

publication

Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization

11 Oct 2023

publication

DAXX safeguards heterochromatin formation in embryonic stem cells

18 Sep 2023

event

Joint Microbiology, BCI, and Structural Biology and Chemistry Departments seminar: Melanie OTT (UCSF, USA) ; “Understanding SARS-CoV-2 Variants through Reverse Genetics” ; Wenesday 27 September @2.00pm; Jules Bordet room

01 Sep 2023

publication

DAXX safeguards heterochromatin formation in embryonic stem cells

31 Aug 2023

publication

A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation

31 Aug 2023

publication

A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation

27 Jul 2023

publication

Advances in Chemical Probing Concepts for Chemical Biology applications

29 Jun 2023

event

“Enjeux politiques de l’antibiorésistance” – Un symposium conjoint Institut Pasteur – Sciences Po

22 May 2023

publication

Plasmodium falciparum Eukaryotic Translation Initiation Factor 3 is Stabilized by Quinazoline-Quinoline Bisubstrate Inhibitors.

22 Mar 2023

publication

Design and synthesis of naturally-inspired SARS-CoV-2 inhibitors.

17 Feb 2023

publication

Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum.

27 Jan 2023

publication

EFMC: Trends in Medicinal Chemistry and Chemical Biology

12 Jan 2023

event

New antiviral strategies: from bench to bedside – A joint Société de Chimie Thérapeutique, Société Française de Virologie & Institut Pasteur Symposium

11 Jan 2023

news

New publication: Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum

10 Nov 2022

course

Resistance to antibacterial agents MOOC

20 Sep 2022

publication

DNA methylome combined with chromosome cluster-oriented analysis provides an early signature for cutaneous melanoma aggressiveness.

01 Jun 2022

publication

Identification of Chemical Probes Targeting MBD2.

12 May 2022

event

2nd PPU-Oxford Bilateral Summit ” Chimie Biologique” – Linking Chemistry and Microbiology to fight human Infectious Diseases

10 May 2022

event

2nd joint Université Paris Cité – Institut Pasteur Antimicrobial Resistance Symposium & Microb’UP Anniversary meeting

10 May 2022

event

Research and innovation to reduce the burden of antibiotic resistance: strengthening the European action

04 Apr 2022

project

TheraEPI

01 Apr 2022

publication

Quinazoline-based analog of adenine as an antidote against MLL-rearranged leukemia cells: synthesis, inhibition assays and docking studies.

16 Mar 2022

event

Half-day Latest innovations and Applications in CryoEM& CryoET

07 Jan 2022

event

Postponed – Joint Conference on Antimicrobial Drug Development

01 Dec 2021

publication

Direct Synthesis of Allyl Amines with 2-Nitrosulfonamide Derivatives via the Tsuji-Trost Reaction.

02 Nov 2021

publication

Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation

26 Oct 2021

publication

The methylome of Biomphalaria glabrata and other mollusks: enduring modification of epigenetic landscape and phenotypic traits by a new DNA methylation inhibitor.

09 Sep 2021

event

Conception et synthèse d’une chimiothèque ciblée contre les épiméthyltransférases

31 Aug 2021

publication

Synthesis and Biological Activity of a Cytostatic Inhibitor of MLLr Leukemia Targeting the DOT1L Protein

30 Aug 2021

event

1st Joint Institut Pasteur – Université de Paris Antimicrobial resistance Symposium

15 Aug 2021

publication

Direct Synthesis of Allyl Amines with 2‐Nitrosulfonamide Derivatives via the Tsuji‐Trost Reaction

22 Jul 2021

publication

Procainamide-SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites.

04 Mar 2021

news

Molecules Webinar The Chemical Biology Research in France

25 Feb 2021

project

DIM 1 HEALTH 2019 project : EpiK- The Cytosine code as potent target to kill pathogens and fight human diseases

18 Feb 2021

project

Epi-Med: synthesis and biological evaluation of new active molecules against MLL-rearranged leukaemia.

18 Feb 2021

project

EpiKillMal- Use of DNA methyltransferase inhibitors to kill drug-resistant malaria parasites –

07 Jan 2021

publication

Targeting Germ Cell Tumors with the Newly Synthesized Flavanone-Derived Compound MLo1302 Efficiently Reduces Tumor Cell Viability and Induces Apoptosis and Cell Cycle Arrest.

17 Sep 2020

publication

Bisubstrate inhibitors: the promise of a selective and potent chemical inhibition of epigenetic ‘writers’

28 Aug 2020

publication

Chapter 4 – Targeting DOT1L for mixed-lineage rearranged leukemia

02 Jul 2020

publication

Wandering along the epigenetic timeline.

15 May 2020

publication

Study of the Effect of Substituents of ortho-Phenylenediamines in the Opening of Lactones and Lactams for Access to Benzimidazol-2-yl Alkanols and Benzimidazol-2-yl Alkylamines.

19 Mar 2020

publication

Bisubstrate-Type Chemical Probes Identify GRP94 as a Potential Target of Cytosine-Containing Adenosine Analogs.

14 Feb 2020

publication

Novel Quinoline Compounds Active in Cancer Cells through Coupled DNA Methyltransferase Inhibition and Degradation

22 Jan 2020

publication

DNA Methylation Bisubstrate Inhibitors Are Fast-Acting Drugs Active against Artemisinin-Resistant Plasmodium falciparum Parasites.

15 Jan 2020

event

Department of Structural Biology seminar: Dr Sébastien Ulrich, Applying concepts of supramolecular chemistry in delivery applications

02 Dec 2019

publication

The timeline of epigenetic drug discovery: from reality to dreams

01 Nov 2019

publication

Synthesis of novel 3-halo-3-nitroflavanones and their activities as DNA methyltransferase inhibitors in cancer cells.

01 Oct 2019

publication

[Chemical targeting of DNA and histone methylation in cancer: Novelties, hopes and promises].

24 Sep 2019

project

Targeting Malaria Epigenetics

17 Sep 2019

event

Department of Structural Biology and Chemistry: Jurgen Brem, Enabling antibiotics to combat multidrug resistant bacteria

03 Aug 2019

publication

The Many Faces of Epigenetics, Oxford, December 2017

01 Jun 2019

publication

The Many Faces of EpigeneticsOxford, December 2017.

22 Feb 2019

event

Department of Structural Biology and Chemistry: Michaela Frye, RNA methylation in stem cells and cancer

16 Jan 2019

publication

Demethylation by low-dose 5-aza-2′-deoxycytidine impairs 3D melanoma invasion partially through miR-199a-3p expression revealing the role of this miR in melanoma

02 Jan 2019

team

UMR3523 – Chemistry for Life Sciences (Chem4Life)

02 Jan 2019

publication

Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells

02 Jan 2019

publication

Assembly of the Entire Carbon Backbone of a Stereoisomer of the Antitumor Marine Natural Product Hemicalide

10 Dec 2018

publication

Natural Products and Chemical Biology Tools: Alternatives to Target Epigenetic Mechanisms in Cancers

07 Dec 2018

event

Seminar of the Structural Biology and Chemistry department: Dr. Maria Duca

17 Oct 2018

publication

Identification of novel quinazoline derivatives as potent antiplasmodial agents

29 Jun 2018

publication

A Quinoline-Based DNA Methyltransferase Inhibitor as a Possible Adjuvant in Osteosarcoma Therapy

05 Jun 2018

publication

The past and presence of gene targeting: from chemicals and DNA via proteins to RNA

05 Jun 2018

publication

09 Apr 2018

event

“DNA bases beyond Watson & Crick” – Pr. Thomas CARELL

06 Apr 2018

publication

The DNMT3A R882H mutant displays altered flanking sequence preferences

03 Apr 2018

event

Bisubstrate analogues as N-methyltransferase inhibitors and tool compounds for structural studies – Nathaniel I. Martin Phd

29 Mar 2018

event

Bisubstrate analogues as N-methyltransferase inhibitors and tool compounds for structural studies

16 Jan 2018

event

Scientific fraud as an industry – Enrico M. Bucci Phd

16 Jan 2018

event

Early Career Unvestigators Meeting on Epigenetic Chemical Biology

15 Jan 2018

publication

Disruptor of telomeric silencing 1-like (DOT1L): disclosing a new class of non-nucleoside inhibitors by means of ligand-based and structure-based approaches

09 Jan 2018

team

Epigenetic Chemical Biology

10 Aug 2017

publication

Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors

23 May 2017

publication

Rational Design of Bisubstrate-Type Analogues as Inhibitors of DNA Methyltransferases in Cancer Cells

17 Feb 2017

program_project

Antimicrobial resistance

05 Jan 2017

publication

DNA Methylation Targeting: The DNMT/HMT Crosstalk Challenge

09 Dec 2016

publication

DNA methyltransferase inhibitors in cancer: From pharmacology to translational studies

31 Aug 2016

publication

Identification of epigenetic factors regulating the mesenchyme to epithelium transition by RNA interference screening in breast cancer cells

15 Mar 2016

publication

Identification and optimization of hydrazone-gallate derivatives as specific inhibitors of DNA methyltransferase 3A

01 Jan 2016

publication

DNA Methyltransferase Inhibitors: Development and Applications

10 Jul 2015

publication

Design and synthesis of new non nucleoside inhibitors of DNMT3A

20 Jun 2015

publication

Consequences of combining siRNA-mediated DNA methyltransferase 1 depletion with 5-aza-2′-deoxycytidine in human leukemic KG1 cells

23 Jan 2015

publication

Combined analysis of DNA methylation and cell cycle in cancer cells

01 Jan 2015

publication

DNA Methylation Analysis of ChIP Products at Single Nucleotide Resolution by Pyrosequencing®

18 Dec 2014

publication

New insights on the mechanism of quinoline-based DNA Methyltransferase inhibitors

04 Dec 2014

publication

Targeting DNA methylation with small molecules: what’s next?

15 Sep 2014

department

Structural Biology and Chemistry

26 Aug 2014

publication

Cytisine-like alkaloids from Ormosia hosiei Hemsl. & E.H. Wilson

01 Jul 2014

publication

Challenges in developing novel DNA methyltransferases inhibitors for cancer therapy

08 May 2014

publication

Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity

01 Mar 2014

publication

Design, synthesis and biological evaluation of 4-amino-N- (4-aminophenyl)benzamide analogues of quinoline-based SGI-1027 as inhibitors of DNA methylation

03 Feb 2014

publication

Synergistic chromatin repression of the tumor suppressor gene RARB in human prostate cancers

15 Jan 2014

publication

Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells

09 Jan 2014

publication

Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1

25 Aug 2013

publication

Development of a universal radioactive DNA methyltransferase inhibition test for high-throughput screening and mechanistic studies

22 Apr 2013

publication

Dichapetalins from Dichapetalum species and their cytotoxic properties

11 Jan 2013

publication

Identification of novel inhibitors of DNA methylation by screening of a chemical library

08 Jan 2013

publication

DNA methylation associated with polycomb repression in retinoic acid receptor β silencing

03 Oct 2012

publication

DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies

11 Sep 2012

publication

Epigenetics

11 Aug 2012

publication

DNA methylation inhibitors in cancer: recent and future approaches

23 Dec 2011

publication

Sequence-specific base pair mimics are efficient topoisomerase IB inhibitors

14 Dec 2011

publication

Rapid synthesis of new DNMT inhibitors derivatives of procainamide

08 Dec 2011

publication

Semisynthetic neoboutomellerone derivatives as ubiquitin-proteasome pathway inhibitors

23 Jun 2011

publication

Potency of inhibition of human DNA topoisomerase I by flavones assessed through physicochemical parameters

15 Jun 2011

publication

Commercial reverse transcriptase as source of false-positive strand-specific RNA detection in human cells

01 Jun 2011

publication

C5-DNA methyltransferase inhibitors: from screening to effects on zebrafish embryo development

13 May 2011

publication

Contributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme–drug–DNA complex

15 Apr 2011

publication

Replication-fork stalling and processing at a single psoralen interstrand crosslink in Xenopus egg extracts

01 Jan 2011

publication

DNA methyltransferase assays

01 Dec 2010

publication

Introduction “DNA and chromosomes: Physical and biological approaches”

24 Aug 2010

publication

Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine

01 Jun 2010

publication

Specific hypomethylated CpGs at the IGF2 locus act as an epigenetic biomarker for familial adenomatous polyposis colorectal cancer

23 Feb 2010

publication

Sequence-specific targeting of IGF-I and IGF-IR genes by camptothecins

01 Apr 2009

publication

Optimized synthesis and enhanced efficacy of novel triplex-forming camptothecin derivatives based on gimatecan

25 Nov 2008

publication

Triplex formation on DNA targets: how to choose the oligonucleotide

01 Aug 2008

publication

The triple helix: 50 years later, the outcome

25 Feb 2008

publication

Targeting MDR1 gene: synthesis and cellular study of modified daunomycin-triplex-forming oligonucleotide conjugates able to inhibit gene expression in resistant cell lines

21 Feb 2008

publication

Single-molecule observations of topotecan-mediated TopIB activity at a unique DNA sequence

20 Dec 2007

publication

HU binds and folds single-stranded DNA

01 Mar 2007

publication

“DNA, more than just a ladder”. A tribute to Michel Duguet (1943-2005)

24 Feb 2007

publication

Thirty years of Escherichia coli DNA gyrase: from in vivo function to single-molecule mechanism

22 Jun 2006

publication

Topoisomerase action on short DNA duplexes reveals requirements for gate and transfer DNA segments

05 Apr 2006

publication

Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides

25 Jan 2006

publication

Synthesis and biological activity of 6H-isoindolo[2,1-a]indol-6-ones, analogues of batracylin, and related compounds

01 Jan 2006

publication

Exploring the cellular activity of camptothecin-triple-helix-forming oligonucleotide conjugates

01 Jul 2005

publication

Triple helix-forming oligonucleotides conjugated to new inhibitors of topoisomerase II: synthesis and binding properties

22 Mar 2005

publication

Activation of camptothecin derivatives by conjugation to triple helix-forming oligonucleotides

18 Feb 2005

publication

Novel carbamate derivatives of 4-beta-amino-4′-O-demethyl-4-desoxypodophyllotoxin as inhibitors of topoisomerase II: synthesis and biological evaluation

27 Jan 2005

publication

Synthesis and biological study of a new series of 4′-demethylepipodophyllotoxin derivatives

04 Oct 2004

publication

Position- and orientation-specific enhancement of topoisomerase I cleavage complexes by triplex DNA structures

22 Apr 2004

publication

Synthesis and biological activity of sulfonamide derivatives of epipodophyllotoxin

12 Feb 2004

publication

Relative DNA binding affinity of helix 3 homeodomain analogues, major groove binders, can be rapidly screened by displacement of prebound ethidium bromide. A comparative study

15 Jul 2003

publication

Spatial organization of topoisomerase I-mediated DNA cleavage induced by camptothecin-oligonucleotide conjugates

01 Jan 2003

publication

Synthesis and antiproliferative activity of basic ethers of 1,2-dihydropyrrolo[1,2-a]indole, 6H-isoindolo[2,1-a]indole, and 6H-benz[5,6]isoindolo[2,1-a]indole

01 Jan 2003

publication

Synthesis and binding properties of oligo-2′-deoxyribonucleotides conjugated with triple-helix-specific intercalators: benzo[e] and benzo[g] pyridoindoles

15 Dec 2002

publication

A directional nucleation-zipping mechanism for triple helix formation

01 Nov 2002

publication

Hemi-synthesis and biological activity of new analogues of podophyllotoxin

01 Sep 2002

publication

Unusual DNA conformations: implications for telomeres

08 Jan 2002

publication

Chemical modification of the third strand: differential effects on purine and pyrimidine triple helix formation

27 Nov 2001

publication

Design and optimization of camptothecin conjugates of triple helix-forming oligonucleotides for sequence-specific DNA cleavage by topoisomerase I

01 Nov 2001

publication

Design of new anti-cancer agents based on topoisomerase poisons targeted to specific DNA sequences

25 Oct 2001

publication

DNA interaction and cytotoxicity of a new series of indolo[2,3-b]quinoxaline and pyridopyrazino[2,3-b]indole derivatives

01 Jul 2001

publication

Triple helix-forming oligonucleotides conjugated to indolocarbazole poisons direct topoisomerase I-mediated DNA cleavage to a specific site

13 Mar 2001

publication

Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay

01 Mar 2001

publication

Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes

15 Feb 2001

publication

Detection of competing DNA structures by thermal gradient gel electrophoresis: from self-association to triple helix formation by (G,A)-containing oligonucleotides

01 Jan 2001

publication

Directing topoisomerase I mediated DNA cleavage to specific sites by camptothecin tethered to minor- and major-groove ligands

15 Dec 2000

publication

Interaction of human DNA topoisomerase I with G-quartet structures

01 Dec 2000

publication

Design of two etoposide-amsacrine conjugates: topoisomerase II and tubuline polymerization inhibition and relation to cytotoxicity

17 Nov 2000

publication

The chromosomal protein HMG-D binds to the TAR and RBE RNA of HIV-1

01 Aug 2000

publication

Linkage of a triple helix-forming oligonucleotide to amsacrine-4-carboxamide derivatives modulates the sequence-selectivity of topoisomerase II-mediated DNA cleavage

13 Apr 2000

publication

Pyrimidine morpholino oligonucleotides form a stable triple helix in the absence of magnesium ions

01 Apr 2000

publication

Recognition and cleavage of DNA by rebeccamycin- or benzopyridoquinoxaline conjugated of triple helix-forming oligonucleotides

03 Sep 1999

publication

Energetics of strand-displacement reactions in triple helices: a spectroscopic study

01 Sep 1999

publication

Targeting topoisomerase I cleavage to specific sequences of DNA by triple helix-forming oligonucleotide conjugates. A comparison between a rebeccamycin derivative and camptothecin

24 Nov 1998

publication

Triple helix formation by (G,A)-containing oligonucleotides: asymmetric sequence effect

19 Oct 1998

publication

Synthesis and Crystal Structure of a Self-Assembled, Octanuclear Oxo-Tantalum(V) Derivative Containing the First Example of a Transition Metal M(8)(&mgr;-O)(12) Cage

A little guide for advanced search:

Supercomputer-based virtual screening for DNMT1 inhibitors as novel anticancer agents

3rd PPU Oxford bilateral summit “Chimie Biologique” – “Tackling AntiMicrobial Resistance, together”

Thesis defense – Synthesis and identification of chemical compounds targeting DNA Methylation reader proteins (By Jean Contreras)

Adenine, a key player in biology and medicinal chemistry

Call for abstracts & Register ! “Tackling antibacterial and antifungal resistant infections from disease to innovative therapies” – an international AMR symposium

Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells

Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells

Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization.

Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization

DAXX safeguards heterochromatin formation in embryonic stem cells

Joint Microbiology, BCI, and Structural Biology and Chemistry Departments seminar: Melanie OTT (UCSF, USA) ; “Understanding SARS-CoV-2 Variants through Reverse Genetics” ; Wenesday 27 September @2.00pm; Jules Bordet room

DAXX safeguards heterochromatin formation in embryonic stem cells

A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation

A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation

Advances in Chemical Probing Concepts for Chemical Biology applications

“Enjeux politiques de l’antibiorésistance” – Un symposium conjoint Institut Pasteur – Sciences Po

Plasmodium falciparum Eukaryotic Translation Initiation Factor 3 is Stabilized by Quinazoline-Quinoline Bisubstrate Inhibitors.

Design and synthesis of naturally-inspired SARS-CoV-2 inhibitors.

Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum.

EFMC: Trends in Medicinal Chemistry and Chemical Biology

New antiviral strategies: from bench to bedside – A joint Société de Chimie Thérapeutique, Société Française de Virologie & Institut Pasteur Symposium

New publication: Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum

Resistance to antibacterial agents MOOC

DNA methylome combined with chromosome cluster-oriented analysis provides an early signature for cutaneous melanoma aggressiveness.

Identification of Chemical Probes Targeting MBD2.

2nd PPU-Oxford Bilateral Summit ” Chimie Biologique” – Linking Chemistry and Microbiology to fight human Infectious Diseases

2nd joint Université Paris Cité – Institut Pasteur Antimicrobial Resistance Symposium & Microb’UP Anniversary meeting

Research and innovation to reduce the burden of antibiotic resistance: strengthening the European action

TheraEPI

Quinazoline-based analog of adenine as an antidote against MLL-rearranged leukemia cells: synthesis, inhibition assays and docking studies.

Half-day Latest innovations and Applications in CryoEM& CryoET

Postponed – Joint Conference on Antimicrobial Drug Development

Direct Synthesis of Allyl Amines with 2-Nitrosulfonamide Derivatives via the Tsuji-Trost Reaction.

Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation

The methylome of Biomphalaria glabrata and other mollusks: enduring modification of epigenetic landscape and phenotypic traits by a new DNA methylation inhibitor.

Conception et synthèse d’une chimiothèque ciblée contre les épiméthyltransférases

Synthesis and Biological Activity of a Cytostatic Inhibitor of MLLr Leukemia Targeting the DOT1L Protein

1st Joint Institut Pasteur – Université de Paris Antimicrobial resistance Symposium

Direct Synthesis of Allyl Amines with 2‐Nitrosulfonamide Derivatives via the Tsuji‐Trost Reaction

Procainamide-SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites.

Molecules Webinar The Chemical Biology Research in France

DIM 1 HEALTH 2019 project : EpiK- The Cytosine code as potent target to kill pathogens and fight human diseases

Epi-Med: synthesis and biological evaluation of new active molecules against MLL-rearranged leukaemia.

EpiKillMal- Use of DNA methyltransferase inhibitors to kill drug-resistant malaria parasites –

Targeting Germ Cell Tumors with the Newly Synthesized Flavanone-Derived Compound MLo1302 Efficiently Reduces Tumor Cell Viability and Induces Apoptosis and Cell Cycle Arrest.

Bisubstrate inhibitors: the promise of a selective and potent chemical inhibition of epigenetic ‘writers’

Chapter 4 – Targeting DOT1L for mixed-lineage rearranged leukemia

Wandering along the epigenetic timeline.

Study of the Effect of Substituents of ortho-Phenylenediamines in the Opening of Lactones and Lactams for Access to Benzimidazol-2-yl Alkanols and Benzimidazol-2-yl Alkylamines.

Bisubstrate-Type Chemical Probes Identify GRP94 as a Potential Target of Cytosine-Containing Adenosine Analogs.

Novel Quinoline Compounds Active in Cancer Cells through Coupled DNA Methyltransferase Inhibition and Degradation

DNA Methylation Bisubstrate Inhibitors Are Fast-Acting Drugs Active against Artemisinin-Resistant Plasmodium falciparum Parasites.

Department of Structural Biology seminar: Dr Sébastien Ulrich, Applying concepts of supramolecular chemistry in delivery applications

The timeline of epigenetic drug discovery: from reality to dreams

Synthesis of novel 3-halo-3-nitroflavanones and their activities as DNA methyltransferase inhibitors in cancer cells.

[Chemical targeting of DNA and histone methylation in cancer: Novelties, hopes and promises].

Targeting Malaria Epigenetics

Department of Structural Biology and Chemistry: Jurgen Brem, Enabling antibiotics to combat multidrug resistant bacteria

The Many Faces of Epigenetics, Oxford, December 2017

The Many Faces of EpigeneticsOxford, December 2017.

Department of Structural Biology and Chemistry: Michaela Frye, RNA methylation in stem cells and cancer

Demethylation by low-dose 5-aza-2′-deoxycytidine impairs 3D melanoma invasion partially through miR-199a-3p expression revealing the role of this miR in melanoma

UMR3523 – Chemistry for Life Sciences (Chem4Life)

Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells

Assembly of the Entire Carbon Backbone of a Stereoisomer of the Antitumor Marine Natural Product Hemicalide

Natural Products and Chemical Biology Tools: Alternatives to Target Epigenetic Mechanisms in Cancers

Seminar of the Structural Biology and Chemistry department: Dr. Maria Duca

Identification of novel quinazoline derivatives as potent antiplasmodial agents

A Quinoline-Based DNA Methyltransferase Inhibitor as a Possible Adjuvant in Osteosarcoma Therapy

The past and presence of gene targeting: from chemicals and DNA via proteins to RNA

“DNA bases beyond Watson & Crick” – Pr. Thomas CARELL

The DNMT3A R882H mutant displays altered flanking sequence preferences

Bisubstrate analogues as N-methyltransferase inhibitors and tool compounds for structural studies – Nathaniel I. Martin Phd

Bisubstrate analogues as N-methyltransferase inhibitors and tool compounds for structural studies

Scientific fraud as an industry – Enrico M. Bucci Phd

Early Career Unvestigators Meeting on Epigenetic Chemical Biology

Disruptor of telomeric silencing 1-like (DOT1L): disclosing a new class of non-nucleoside inhibitors by means of ligand-based and structure-based approaches

Epigenetic Chemical Biology

Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors