Timeline
Chiara Zurzolo
Head of Structure
01 Dec 2023
publication
CellWalker: a user-friendly and modular computational pipeline for morphological analysis of microscopy images.
Read more27 Nov 2023
publication
Tunnelling nanotube formation is driven by Eps8/IRSp53‐dependent linear actin polymerization
Read more01 Nov 2023
publication
Identification and Characterization of Tunneling Nanotubes for Intercellular Trafficking.
Read more01 Jul 2023
publication
Calcium-binding Cab45 regulates the polarized apical secretion of soluble proteins in epithelial cells.
Read more15 Jun 2023
news
New publication – Tunnelling nanotubes between neuronal and microglial cells allow bi-directional transfer of α-Synuclein and mitochondria
Read more18 May 2023
publication
Tunnelling nanotubes between neuronal and microglial cells allow bi-directional transfer of α-Synuclein and mitochondria.
Read more05 Apr 2023
publication
3D reconstruction of the cerebellar germinal layer reveals tunneling connections between developing granule cells.
Read more01 Nov 2022
22 Jul 2022
22 Jul 2022
15 Nov 2021
publication
Seeing eye to eye: photoreceptors employ nanotube-like connections for material transfer
Read more17 Aug 2021
publication
Calcium levels in the Golgi complex regulate clustering and apical sorting of GPI-APs in polarized epithelial cells.
Read more01 Aug 2021
20 Jul 2021
news
Parkinson’s disease: the implication of lysosomes in the propagation of the pathology
Read more01 Jul 2021
publication
α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes.
Read more04 May 2021
01 Mar 2021
01 Feb 2021
15 Jan 2021
publication
Patient-derived glioblastoma stem cells transfer mitochondria through tunneling nanotubes in tumor organoids.
Read more12 Nov 2020
08 Oct 2020
publication
Rab35 and its effectors promote formation of tunneling nanotubes in neuronal cells.
Read more01 Oct 2020
01 Sep 2020
30 Jun 2020
publication
The best of both worlds- bringing together cell biology and infection at the Institut Pasteur.
Read more12 May 2020
publication
Actin Assembly around the Shigella-Containing Vacuole Promotes Successful Infection.
Read more07 Jan 2020
publication
Fine intercellular connections in development: TNTs, cytonemes, or intercellular bridges?
Read more02 Dec 2019
publication
The Wnt/Ca2+ pathway is involved in interneuronal communication mediated by tunneling nanotubes.
Read more01 Dec 2019
publication
Human NPCs can degrade α-syn fibrils and transfer them preferentially in a cell contact-dependent manner possibly through TNT-like structures.
Read more01 Sep 2019
publication
Clustering in the Golgi apparatus governs sorting and function of GPI-APs in polarized epithelial cells.
Read more26 Aug 2019
event
BCI Seminar – “Cytoskeletal cross-talk with integrin adhesion complexes in cell morphogenesis”
Read more05 Apr 2019
01 Mar 2019
publication
The prion-like spreading of α-synuclein: From in vitro to in vivo models of Parkinson’s disease.
Read more21 Jan 2019
publication
Correlative cryo-electron microscopy reveals the structure of TNTs in neuronal cells
Read more19 Nov 2018
project
Mechanisms of GPI-anchored protein apical sorting and plasma membrane organization in polarized epithelial cells.
Read more18 Nov 2018
project
Prion-like proteins spreading in neurodegenerative diseases: role of Tunneling Nanotubes (TNTs)
Read more17 Nov 2018
16 Nov 2018
05 Oct 2018
publication
Rab11a-Rab8a cascade regulates the formation of tunneling nanotubes through vesicle recycling
Read more24 Jul 2018
publication
Organization of GPI-anchored proteins at the cell surface and its physiopathological relevance
Read more02 Jul 2018
21 Mar 2018
event
Pasteur-Weizmann Council Seminar hosted by the Department of Cell Biology and infection – “Characterizing the Host-pathogen Crosstalk at Early Stages of Infection”
Read more11 Dec 2017
event
“Capture of transport vesicles at the Golgi by golgin coiled-coil proteins” – Sean Munro
Read more11 Dec 2017
11 Dec 2017
event
“Spacetime at the cell scale: how do “clocks” and “rulers” crosstalk to control chromosome segregation during mitosis?” – Helder Maiato
Read more01 Dec 2017
publication
GPI-anchored proteins are confined in subdiffraction clusters at the apical surface of polarized epithelial cells
Read more17 Oct 2017
publication
Tunneling Nanotubes and Gap Junctions-Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions.
Read more29 Jul 2017
19 Jul 2017
publication
The spread of prion-like proteins by lysosomes and tunneling nanotubes: Implications for neurodegenerative diseases
Read more19 Jul 2017
publication
α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading.
Read more16 Jun 2017
publication
Regulation of sub-compartmental targeting and folding properties of the Prion-like protein Shadoo
Read more05 Apr 2017
event
« From fitness comparison to spatial constrains, the many roads of cell competition »
Read more22 Mar 2017
event
“Molecular and biological drivers of pathological alpha-synuclein propagation and spread” – Kelvin Luk
Read more01 Mar 2017
publication
Transfer of disrupted-in-schizophrenia 1 aggregates between neuronal-like cells occurs in tunnelling nanotubes and is promoted by dopamine
Read more19 Jan 2017
18 Jan 2017
23 Dec 2016
publication
Differential identity of Filopodia and Tunneling Nanotubes revealed by the opposite functions of actin regulatory complexes
Read more12 Dec 2016
22 Nov 2016
event
Cell Biology and Infection Day – December 1, 2016 Institut Pasteur, Paris, France Amphithéâtre Duclaux
Read more02 Sep 2016
publication
Tunneling nanotubes: A possible highway in the spreading of tau and other prion-like proteins in neurodegenerative diseases
Read more22 Aug 2016
publication
Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes
Read more08 Jul 2016
07 Jul 2016
publication
PrPC Undergoes Basal to Apical Transcytosis in Polarized Epithelial MDCK Cells
Read more03 May 2016
13 Apr 2016
publication
The 37/67 kDa laminin receptor (LR) inhibitor, NSC47924, affects 37/67 kDa LR cell surface localization and interaction with the cellular prion protein
Read more16 Mar 2016
publication
Drosophila cells use nanotube-like structures to transfer dsRNA and RNAi machinery between cells.
Read more09 Feb 2016
publication
Astrocyte-to-neuron intercellular prion transfer is mediated by cell-cell contact
Read more17 Dec 2015
publication
Glycosylphosphatidylinositol-anchored proteins: Membrane organization and transport
Read more01 Jun 2015
publication
Identification and Characterization of Tunneling Nanotubes for Intercellular Trafficking
Read more27 May 2015
11 May 2015
15 Apr 2015
publication
Trafficking and Membrane Organization of GPI-Anchored Proteins in Health and Diseases
Read more30 Mar 2015
01 Mar 2015
16 Sep 2014
06 Jun 2014
publication
Sorting of GPI-anchored proteins from yeast to mammals–common pathways at different sites?
Read more04 Jun 2014
30 Mar 2014
publication
Golgi sorting regulates organization and activity of GPI proteins at apical membranes
Read more10 Dec 2013
publication
Exploring the role of lipids in intercellular conduits: breakthroughs in the pipeline
Read more31 Oct 2013
publication
The fate of PrP GPI-anchor signal peptide is modulated by P238S pathogenic mutation
Read more25 Jul 2013
19 Jul 2013
18 Jun 2013
publication
Transfer of polyglutamine aggregates in neuronal cells occurs in tunneling nanotubes
Read more15 May 2013
publication
The cell biology of prion-like spread of protein aggregates: mechanisms and implication in neurodegeneration
Read more15 Mar 2013
publication
Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation
Read more15 Feb 2013
publication
4-hydroxytamoxifen leads to PrPSc clearance by conveying both PrPC and PrPSc to lysosomes independently of autophagy
Read more27 Nov 2012
publication
Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons
Read more10 Apr 2012
07 Mar 2012
publication
Wiring through tunneling nanotubes–from electrical signals to organelle transfer
Read more28 Feb 2012
publication
Determining the role of mononuclear phagocytes in prion neuroinvasion from the skin
Read more12 Oct 2011
publication
N-Glycosylation instead of cholesterol mediates oligomerization and apical sorting of GPI-APs in FRT cells
Read more07 Sep 2011
publication
Cluvenone induces apoptosis via a direct target in mitochondria: a possible mechanism to circumvent chemo-resistance?
Read more15 Oct 2010
publication
Characterization of the role of dendritic cells in prion transfer to primary neurons
Read more23 Dec 2009
publication
Doppel and PrPC co-immunoprecipitate in detergent-resistant membrane domains of epithelial FRT cells
Read more08 Jun 2009
publication
Lipid rafts and clathrin cooperate in the internalization of PrP in epithelial FRT cells
Read more08 May 2009
01 Apr 2009
15 Mar 2009
08 Feb 2009
15 Dec 2008
publication
Different GPI-attachment signals affect the oligomerisation of GPI-anchored proteins and their apical sorting
Read more06 Sep 2008
publication
N- and O-glycans are not directly involved in the oligomerization and apical sorting of GPI proteins
Read more12 Aug 2008
publication
Selective roles for cholesterol and actin in compartmentalization of different proteins in the Golgi and plasma membrane of polarized cells
Read more04 Jun 2008
publication
alpha-Adducin mutations increase Na/K pump activity in renal cells by affecting constitutive endocytosis: implications for tubular Na reabsorption
Read more10 Apr 2008
publication
Coexpression of wild-type and mutant prion proteins alters their cellular localization and partitioning into detergent-resistant membranes
Read more25 Nov 2007
publication
Gene expression profile of quinacrine-cured prion-infected mouse neuronal cells
Read more15 Sep 2007
publication
Distinct v-SNAREs regulate direct and indirect apical delivery in polarized epithelial cells
Read more07 Jun 2007
publication
Characterization of the properties and trafficking of an anchorless form of the prion protein
Read more01 Mar 2007
publication
Oligomerization is a specific requirement for apical sorting of glycosyl-phosphatidylinositol-anchored proteins but not for non-raft-associated apical proteins
Read more20 Sep 2006
publication
Analysis of detergent-resistant membranes associated with apical and basolateral GPI-anchored proteins in polarized epithelial cells
Read more20 Mar 2006
publication
GPI-anchored proteins are directly targeted to the apical surface in fully polarized MDCK cells
Read more01 Feb 2006
publication
Detergent-resistant membrane domains but not the proteasome are involved in the misfolding of a PrP mutant retained in the endoplasmic reticulum
Read more01 Jan 2006
24 Oct 2005
publication
Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells
Read more01 May 2005
publication
A y(+)LAT-1 mutant protein interferes with y(+)LAT-2 activity: implications for the molecular pathogenesis of lysinuric protein intolerance
Read more01 Feb 2005
01 Jan 2005
publication
Functional interaction between p75NTR and TrkA: the endocytic trafficking of p75NTR is driven by TrkA and regulates TrkA-mediated signalling
Read more22 Nov 2004
publication
Protein oligomerization modulates raft partitioning and apical sorting of GPI-anchored proteins
Read more01 Jul 2004
publication
The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes
Read more30 Jun 2004
publication
PrP(C) association with lipid rafts in the early secretory pathway stabilizes its cellular conformation
Read more15 Apr 2004
publication
The neuroendocrine protein VGF is sorted into dense-core granules and is secreted apically by polarized rat thyroid epithelial cells
Read more01 Apr 2004
21 Nov 2003
01 Feb 2003
01 Nov 2002
publication
PrPC is sorted to the basolateral membrane of epithelial cells independently of its association with rafts
Read more01 Apr 2002
publication
Differential recognition of a tyrosine-dependent signal in the basolateral and endocytic pathways of thyroid epithelial cells
Read more01 Feb 2002
publication