Timeline

Chiara Zurzolo
Head of Structure
26 Aug 2019
event

BCI Seminar – “Cytoskeletal cross-talk with integrin adhesion complexes in cell morphogenesis”

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05 Apr 2019
publication

Effect of tolytoxin on tunneling nanotube formation and function

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21 Jan 2019
publication

Correlative cryo-electron microscopy reveals the structure of TNTs in neuronal cells

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19 Nov 2018
project

Mechanisms of GPI-anchored protein apical sorting and plasma membrane organization in polarized epithelial cells.

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18 Nov 2018
project

Prion-like proteins spreading in neurodegenerative diseases: role of Tunneling Nanotubes (TNTs)

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17 Nov 2018
project

Role of TNTs in tumor networking, heterogeneity, and resistance to therapy.

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16 Nov 2018
project

Unraveling the structure/function of TNTs in vitro and in vivo.

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05 Oct 2018
publication

Rab11a-Rab8a cascade regulates the formation of tunneling nanotubes through vesicle recycling

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24 Jul 2018
publication

Organization of GPI-anchored proteins at the cell surface and its physiopathological relevance

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02 Jul 2018
publication

Synergistic inactivation of AXL: a (cross)road to cure ovarian cancer?

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21 Mar 2018
event

Pasteur-Weizmann Council Seminar hosted by the Department of Cell Biology and infection – “Characterizing the Host-pathogen Crosstalk at Early Stages of Infection”

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11 Dec 2017
event

“Capture of transport vesicles at the Golgi by golgin coiled-coil proteins” – Sean Munro

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11 Dec 2017
event

“Glycosphingolipid reprogramming drives neural differentiation” – Giovanni d’Angelo

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11 Dec 2017
event

“Spacetime at the cell scale: how do “clocks” and “rulers” crosstalk to control chromosome segregation during mitosis?” – Helder Maiato

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01 Dec 2017
publication

GPI-anchored proteins are confined in subdiffraction clusters at the apical surface of polarized epithelial cells

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17 Oct 2017
publication

Tunneling Nanotubes and Gap Junctions-Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions

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29 Jul 2017
publication

Cell Biology of Prion Protein

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19 Jul 2017
publication

α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading

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19 Jul 2017
publication

The spread of prion-like proteins by lysosomes and tunneling nanotubes: Implications for neurodegenerative diseases

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16 Jun 2017
publication

Regulation of sub-compartmental targeting and folding properties of the Prion-like protein Shadoo

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05 Apr 2017
event

« From fitness comparison to spatial constrains, the many roads of cell competition »

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22 Mar 2017
event

“Molecular and biological drivers of pathological alpha-synuclein propagation and spread” – Kelvin Luk

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01 Mar 2017
publication

Transfer of disrupted-in-schizophrenia 1 aggregates between neuronal-like cells occurs in tunnelling nanotubes and is promoted by dopamine

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19 Jan 2017
event

Cellular mechanisms of Mycobacterium tuberculosis phagosome integrity maintenance

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18 Jan 2017
event

Seminar “Salmonella single-cell biology in complex host tissues”

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23 Dec 2016
publication

Differential identity of Filopodia and Tunneling Nanotubes revealed by the opposite functions of actin regulatory complexes

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12 Dec 2016
event

Sjaak Neefjes seminar

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22 Nov 2016
event

Cell Biology and Infection Day – December 1, 2016 Institut Pasteur, Paris, France Amphithéâtre Duclaux

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02 Sep 2016
publication

Tunneling nanotubes: A possible highway in the spreading of tau and other prion-like proteins in neurodegenerative diseases

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22 Aug 2016
publication

Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes

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08 Jul 2016
project

Adult neurogenesis and brain plasticity

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07 Jul 2016
publication

PrPC Undergoes Basal to Apical Transcytosis in Polarized Epithelial MDCK Cells

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03 Jun 2016
publication

Drosophila cells use nanotube-like structures to transfer dsRNA and RNAi machinery between cells

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03 May 2016
publication

The Priority position paper: Protecting Europe’s food chain from prions

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13 Apr 2016
publication

The 37/67 kDa laminin receptor (LR) inhibitor, NSC47924, affects 37/67 kDa LR cell surface localization and interaction with the cellular prion protein

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09 Feb 2016
publication

Astrocyte-to-neuron intercellular prion transfer is mediated by cell-cell contact

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17 Dec 2015
publication

Glycosylphosphatidylinositol-anchored proteins: Membrane organization and transport

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01 Jun 2015
publication

Identification and Characterization of Tunneling Nanotubes for Intercellular Trafficking

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27 May 2015
publication

Cytosolically expressed PrP GPI-signal peptide interacts with mitochondria

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11 May 2015
team

Membrane Traffic and Pathogenesis

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15 Apr 2015
publication

Trafficking and Membrane Organization of GPI-Anchored Proteins in Health and Diseases

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30 Mar 2015
publication

Chiara Zurzolo: GPI knows the way to go

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01 Mar 2015
publication

Prion aggregates transfer through tunneling nanotubes in endocytic vesicles

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16 Sep 2014
department

Cell Biology & Infection

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06 Jun 2014
publication

Sorting of GPI-anchored proteins from yeast to mammals–common pathways at different sites?

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04 Jun 2014
publication

Defined α-synuclein prion-like molecular assemblies spreading in cell culture

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30 Mar 2014
publication

Golgi sorting regulates organization and activity of GPI proteins at apical membranes

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10 Dec 2013
publication

Exploring the role of lipids in intercellular conduits: breakthroughs in the pipeline

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31 Oct 2013
publication

The fate of PrP GPI-anchor signal peptide is modulated by P238S pathogenic mutation

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25 Jul 2013
publication

Myo10 is a key regulator of TNT formation in neuronal cells

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19 Jul 2013
publication

Not on the menu: autophagy-independent clearance of prions

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18 Jun 2013
publication

Transfer of polyglutamine aggregates in neuronal cells occurs in tunneling nanotubes

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15 May 2013
publication

The cell biology of prion-like spread of protein aggregates: mechanisms and implication in neurodegeneration

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15 Mar 2013
publication

Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation

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15 Feb 2013
publication

4-hydroxytamoxifen leads to PrPSc clearance by conveying both PrPC and PrPSc to lysosomes independently of autophagy

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27 Nov 2012
publication

Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons

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10 Apr 2012
publication

Multifaceted roles of tunneling nanotubes in intercellular communication

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07 Mar 2012
publication

Wiring through tunneling nanotubes–from electrical signals to organelle transfer

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28 Feb 2012
publication

Determining the role of mononuclear phagocytes in prion neuroinvasion from the skin

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12 Oct 2011
publication

N-Glycosylation instead of cholesterol mediates oligomerization and apical sorting of GPI-APs in FRT cells

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07 Sep 2011
publication

Cluvenone induces apoptosis via a direct target in mitochondria: a possible mechanism to circumvent chemo-resistance?

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15 Oct 2010
publication

Characterization of the role of dendritic cells in prion transfer to primary neurons

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23 Dec 2009
publication

Doppel and PrPC co-immunoprecipitate in detergent-resistant membrane domains of epithelial FRT cells

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08 Jun 2009
publication

Lipid rafts and clathrin cooperate in the internalization of PrP in epithelial FRT cells

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08 May 2009
publication

Identification of an intracellular site of prion conversion

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01 Apr 2009
publication

Tunnelling nanotubes: a highway for prion spreading?

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15 Mar 2009
publication

Development of antibody fragments for immunotherapy of prion diseases

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08 Feb 2009
publication

Prions hijack tunnelling nanotubes for intercellular spread

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15 Dec 2008
publication

Different GPI-attachment signals affect the oligomerisation of GPI-anchored proteins and their apical sorting

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06 Sep 2008
publication

N- and O-glycans are not directly involved in the oligomerization and apical sorting of GPI proteins

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12 Aug 2008
publication

Selective roles for cholesterol and actin in compartmentalization of different proteins in the Golgi and plasma membrane of polarized cells

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04 Jun 2008
publication

alpha-Adducin mutations increase Na/K pump activity in renal cells by affecting constitutive endocytosis: implications for tubular Na reabsorption

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10 Apr 2008
publication

Coexpression of wild-type and mutant prion proteins alters their cellular localization and partitioning into detergent-resistant membranes

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25 Nov 2007
publication

Gene expression profile of quinacrine-cured prion-infected mouse neuronal cells

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15 Sep 2007
publication

Distinct v-SNAREs regulate direct and indirect apical delivery in polarized epithelial cells

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07 Jun 2007
publication

Characterization of the properties and trafficking of an anchorless form of the prion protein

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01 Mar 2007
publication

Oligomerization is a specific requirement for apical sorting of glycosyl-phosphatidylinositol-anchored proteins but not for non-raft-associated apical proteins

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20 Sep 2006
publication

Analysis of detergent-resistant membranes associated with apical and basolateral GPI-anchored proteins in polarized epithelial cells

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20 Mar 2006
publication

GPI-anchored proteins are directly targeted to the apical surface in fully polarized MDCK cells

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01 Feb 2006
publication

Detergent-resistant membrane domains but not the proteasome are involved in the misfolding of a PrP mutant retained in the endoplasmic reticulum

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01 Jan 2006
publication

Prions: protein only or something more? Overview of potential prion cofactors

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24 Oct 2005
publication

Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells

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01 May 2005
publication

A y(+)LAT-1 mutant protein interferes with y(+)LAT-2 activity: implications for the molecular pathogenesis of lysinuric protein intolerance

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01 Feb 2005
publication

The highways and byways of prion protein trafficking

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01 Jan 2005
publication

Functional interaction between p75NTR and TrkA: the endocytic trafficking of p75NTR is driven by TrkA and regulates TrkA-mediated signalling

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22 Nov 2004
publication

Protein oligomerization modulates raft partitioning and apical sorting of GPI-anchored proteins

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01 Jul 2004
publication

The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes

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30 Jun 2004
publication

PrP(C) association with lipid rafts in the early secretory pathway stabilizes its cellular conformation

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15 Apr 2004
publication

The neuroendocrine protein VGF is sorted into dense-core granules and is secreted apically by polarized rat thyroid epithelial cells

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01 Apr 2004
publication

Lipids as targeting signals: lipid rafts and intracellular trafficking

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21 Nov 2003
publication

The order of rafts. Conference on microdomains, lipid rafts and caveolae

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01 Feb 2003
publication

Sensitivity of polarized epithelial cells to the pore-forming toxin aerolysin

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01 Nov 2002
publication

PrPC is sorted to the basolateral membrane of epithelial cells independently of its association with rafts

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01 Apr 2002
publication

Differential recognition of a tyrosine-dependent signal in the basolateral and endocytic pathways of thyroid epithelial cells

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01 Feb 2002
publication

Detergent-resistant membrane microdomains and apical sorting of GPI-anchored proteins in polarized epithelial cells

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