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© Research
Publication : Current topics in membranes

Trafficking and Membrane Organization of GPI-Anchored Proteins in Health and Diseases

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current topics in membranes - 15 Apr 2015

Paladino S, Lebreton S, Zurzolo C

Link to Pubmed [PMID] – 26015286

Curr Top Membr 2015;75:269-303

Glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) are a class of lipid-anchored proteins attached to the membranes by a glycolipid anchor that is added, as posttranslation modification, in the endoplasmic reticulum. GPI-APs are expressed at the cell surface of eukaryotes where they play diverse vital functions. Like all plasma membrane proteins, GPI-APs must be correctly sorted along the different steps of the secretory pathway to their final destination. The presence of both a glycolipid anchor and a protein portion confers special trafficking features to GPI-APs. Here, we discuss the recent advances in the field of GPI-AP trafficking, focusing on the mechanisms regulating their biosynthetic pathway and plasma membrane organization. We also discuss how alterations of these mechanisms can result in different diseases. Finally, we will examine the strict relationship between the trafficking and function of GPI-APs in epithelial cells.

http://www.ncbi.nlm.nih.gov/pubmed/26015286