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© Research
Scientific Fields
Diseases
Organisms
Applications
Technique
Date
07
Oct 2019
Time
12:00:00
Institut Pasteur, 28 Rue du Docteur Roux, Paris, France
Address
Building: François JACOB
Location
2019-10-07 12:00:00 2019-10-07 13:45:00 Europe/Paris BCI Seminar – “Cytoskeletal cross-talk with integrin adhesion complexes in cell morphogenesis”   BCI Seminar – “Cytoskeletal cross-talk with integrin adhesion complexes in cell morphogenesis“ presented by Alexander D BERSHADSKY (Senior Principal Research Scientist/Research Professor,Mechanobiology Institute, Singapore, National University of Singapore, Professor Emeritus Department of Molecular […] Institut Pasteur, 28 Rue du Docteur Roux, Paris, France Guillaume Dumenil guillaume.dumenil@pasteur.fr

Speakers

Alexander D BERSHADSKY
(Weizmann Institute of Science)

About

 

BCI Seminar – Cytoskeletal cross-talk with integrin adhesion complexes in cell morphogenesis

presented by Alexander D BERSHADSKY

(Senior Principal Research Scientist/Research Professor,Mechanobiology Institute, Singapore, National University of Singapore, Professor Emeritus Department of Molecular Cell Biology, Weizmann Institute of Science)

Monday, October 7th , 2019 at 12 :00

Room Auditorium François JACOB

Invited by Guillaume DUMENIL & Chiara ZURZOLO

(guillaume.dumenil@pasteur.fr) & (chiara.zurzolo@pasteur.fr)

Abstract :

Actomyosin cytoskeleton and cell-matrix adhesions are the key elements determining cell morphogenesis. Transmembrane integrin adhesion receptors trigger the assembly of various types of associated actin-based structures, such as focal adhesions, filopodia, and podosomes. These structures are all force dependent and their dynamics and function are controlled by myosin-IIA-filaments in a differential manner. A feedback response from the integrin adhesions to the myosin IIA filaments is in part mediated by another essential cytoskeletal system, microtubules. Guanine nucleotide exchange factor GEF-H1 is trapped and inactivated by microtubules when they are coupled with integrin adhesions via KANK family proteins. Uncoupling microtubules from the integrin adhesions allows the release and activation of GEF-H1 followed by triggering Rho/ Rho kinase (ROCK) pathway, and thereby the assembly of myosin IIA filaments, which in turn remodel the adhesions. Another facet of focal adhesion function is the nucleation of centripetal growth of actin filament bundles (radial fibers), mediated by formin family regulators of actin polymerization. This process provides a mechanism for establishing left-right asymmetry in the course of actomyosin cytoskeleton self-organization. References: YH Tee et al. Nat Cell Biol. 2015, 17:445-457. S Hu et al. Nat Cell Biol. 2017, 19:133-141. NBM Rafiq et al. Nature Materials 2019, 18:638-649.

Location

Building: François JACOB
Address: Institut Pasteur, 28 Rue du Docteur Roux, Paris, France