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© Research
Publication : FEBS letters

Analysis of detergent-resistant membranes associated with apical and basolateral GPI-anchored proteins in polarized epithelial cells

Team: Membrane Traffic and Pathogenesis
Member: Chiara Zurzolo
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in FEBS letters - 20 Sep 2006

Tivodar S, Paladino S, Pillich R, Prinetti A, Chigorno V, van Meer G, Sonnino S, Zurzolo C

Link to Pubmed [PMID] – 17007841

FEBS Lett. 2006 Oct;580(24):5705-12

Detergent-resistant membranes (DRMs) represent specialized membrane domains resistant to detergent extraction, which may serve to segregate proteins in a specific environment in order to improve their function. Segregation of glycosylphosphatidylinositol-anchored proteins (GPI-APs) in DRMs has been shown to be involved in their sorting to the apical membrane in polarized epithelial cells. Nonetheless, we have shown that both apical and basolateral GPI-APs associate with DRMs. In this report we investigated the lipid composition of DRMs associated with an apical and a basolateral GPI-AP. We found that apical and basolateral DRMs contain the same lipid species although in different ratios. This specific lipid ratio is maintained after mixing the cells before lysis indicating that DRMs maintain their identity after Triton extraction.