Timeline
Michel Cohen-Tannoudji
Group Leader
22 Oct 2024
publication
PI3K/AKT signaling controls ICM maturation and proper epiblast and primitive endoderm specification in mice.
Read more04 Oct 2024
publication
Nr5a2 is dispensable for zygotic genome activation but essential for morula development
Read more30 May 2024
news
16e Colloque des Belles Souris à Lyon 7 novembre 2024 – format hybride en présentiel et distanciel
Read more27 May 2024
publication
Molecular and epistatic interactions between pioneer transcription factors shape nucleosome dynamics and cell differentiation
Read more13 Jan 2024
21 Jun 2023
publication
PI3K/AKT signalling orchestrates ICM maturation and proper epiblast and primitive endoderm specification
Read more18 Jan 2023
01 Sep 2022
publication
H3K9 tri-methylation at Nanog times differentiation commitment and enables the acquisition of primitive endoderm fate.
Read more22 Jul 2022
publication
OCT4 activates a Suv39h1-repressive antisense lncRNA to couple histone H3 Lysine 9 methylation to pluripotency.
Read more21 Jun 2022
publication
NANOG initiates epiblast fate through the coordination of pluripotency genes expression.
Read more01 Jan 2021
publication
Microfabricated Device for High-Resolution Imaging of Preimplantation Embryos.
Read more18 Dec 2020
publication
Fast In Vitro Procedure to Identify Extraembryonic Differentiation Defect of Mouse Embryonic Stem Cells.
Read more17 Jun 2020
publication
Direct Readout of Neural Stem Cell Transgenesis with an Integration-Coupled Gene Expression Switch.
Read more30 Apr 2020
publication
Compensation between Wnt-driven tumorigenesis and cellular responses to ribosome biogenesis inhibition in the murine intestinal epithelium
Read more10 Jan 2020
10 Oct 2019
publication
CTCF confers local nucleosome resiliency after DNA replication and during mitosis
Read more26 Mar 2019
publication
PDGF signaling in primitive endoderm cell survival is mediated by PI3K-mTOR through p53-independent mechanism
Read more17 Jan 2019
26 Nov 2018
publication
Notchless defines a stage-specific requirement for ribosome biogenesis during lineage progression in adult skeletal myogenesis
Read more21 Sep 2018
17 Sep 2018
03 Sep 2018
event
PhD Thesis defense: “In vivo exploration of the impact of ribosome biogenesis alterations on intestinal homeostasis and tumorigenesis in the adult mouse”
Read more24 Jan 2018
publication
Argonaute 2 Is Required for Extra-embryonic Endoderm Differentiation of Mouse Embryonic Stem Cells
Read more25 Sep 2017
publication
ICM conversion to epiblast by FGF/ERK inhibition is limited in time and requires transcription and protein degradation
Read more09 Jun 2017
publication
A multiscale model of early cell lineage specification including cell division
Read more03 Mar 2017
17 Feb 2017
publication
Optimization of the production of knock-in alleles by CRISPR/Cas9 microinjection into the mouse zygote
Read more10 Oct 2016
publication
Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network
Read more20 Sep 2016
02 Dec 2015
19 Nov 2015
01 Nov 2015
publication
NOTCH activation interferes with cell fate specification in the gastrulating mouse embryo
Read more17 Sep 2015
17 Sep 2015
project
Epiblast/Primitive Endoderm specification and differentiation during early mouse development
Read more27 Aug 2015
27 Aug 2015
16 Jul 2015
12 Jun 2015
publication
Ribosome biogenesis dysfunction leads to p53-mediated apoptosis and goblet cell differentiation of mouse intestinal stem/progenitor cells
Read more09 Jun 2015
09 Jun 2015
11 May 2015
29 Aug 2014
publication
Oocyte-specific inactivation of Omcg1 leads to DNA damage and c-Abl/TAp63-dependent oocyte death associated with dramatic remodeling of ovarian somatic cells
Read more29 May 2014
23 Sep 2013
publication
Notchless-dependent ribosome synthesis is required for the maintenance of adult hematopoietic stem cells
Read more01 Sep 2013
publication
PDGF signaling is required for primitive endoderm cell survival in the inner cell mass of the mouse blastocyst
Read more23 May 2012
publication
Omcg1 is critically required for mitosis in rapidly dividing mouse intestinal progenitors and embryonic stem cells
Read more23 May 2012
publication
Integration of H-2Z1, a somatosensory cortex-expressed transgene, interferes with the expression of the Satb1 and Tbc1d5 flanking genes and affects the differentiation of a subset of cortical interneurons
Read more19 Jan 2012
publication
[Reconsidering the roles of female germ cells in ovarian development and folliculogenesis]
Read more27 Dec 2011
publication
Naive and primed murine pluripotent stem cells have distinct miRNA expression profiles
Read more28 Apr 2011
01 Jan 2011
publication
DNA-RNA hybrids contribute to the replication dependent genomic instability induced by Omcg1 deficiency
Read more01 Nov 2009
publication
Numb promotes an increase in skeletal muscle progenitor cells in the embryonic somite
Read more17 Mar 2009
publication
Distinct phenotypic and functional features of CADASIL mutations in the Notch3 ligand binding domain
Read more13 Jan 2009
01 Dec 2007
publication
[Nobel Prize 2007 for Medicine to Mario Capecchi, Martin Evans and Oliver Smithies: the mutant mice to order]
Read more21 Nov 2007
23 Mar 2007
publication
Conditional knock-out reveals that zygotic vezatin-null mouse embryos die at implantation
Read more01 Jan 2007
01 Jul 2006
publication
RBP-Jkappa-dependent notch signaling is dispensable for mouse early embryonic development
Read more16 Jun 2006
publication
Nuclear mRNA degradation pathway(s) are implicated in Xist regulation and X chromosome inactivation
Read more01 Jun 2006
publication
Nas transgenic mouse line allows visualization of Notch pathway activity in vivo
Read more01 May 2006
publication
The murine ortholog of notchless, a direct regulator of the notch pathway in Drosophila melanogaster, is essential for survival of inner cell mass cells
Read more01 Mar 2006
01 Dec 2005
publication
The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice
Read more01 Jul 2005
publication
Impaired mitotic progression and preimplantation lethality in mice lacking OMCG1, a new evolutionarily conserved nuclear protein
Read more01 Mar 2005
31 Dec 2004
publication
Development of a targeted transgenesis strategy in highly differentiated cells: a powerful tool for functional genomic analysis
Read more01 Oct 2004
publication
Developmental expression of the Notch signaling pathway genes during mouse preimplantation development
Read more30 Jun 2004
publication
Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment
Read more21 Aug 2002
publication
Transcript map of the Ovum mutant (Om) locus: isolation by exon trapping of new candidate genes for the DDK syndrome
Read more01 Sep 2001
publication
Genome engineering via homologous recombination in mouse embryonic stem (ES) cells: an amazingly versatile tool for the study of mammalian biology
Read more15 Sep 2000
publication
A 2-Mb YAC/BAC-based physical map of the ovum mutant (Om) locus region on mouse chromosome 11
Read more01 Jun 2000
01 Feb 2000
publication
BALB/c alleles at modifier loci increase the severity of the maternal effect of the “DDK syndrome”
Read more01 Jan 2000
01 Sep 1999
publication
Role of thalamic axons in the expression of H-2Z1, a mouse somatosensory cortex specific marker
Read more23 Aug 1999
publication
In vivo, villin is required for Ca(2+)-dependent F-actin disruption in intestinal brush borders
Read more15 Jun 1999
01 Dec 1998
publication
Nonpermissiveness for mouse embryonic stem (ES) cell derivation circumvented by a single backcross to 129/Sv strain: establishment of ES cell lines bearing the Omd conditional lethal mutation
Read more01 Oct 1998
publication
Beyond ‘knock-out’ mice: new perspectives for the programmed modification of the mammalian genome
Read more01 Mar 1998
01 Jul 1997
publication
The acceleration-velocity relationship: identification of normal and spastic upper extremity movement.
Read more01 Jun 1996
publication
CD4 T cell tolerance to nuclear proteins induced by medullary thymic epithelium
Read more01 Feb 1996
01 Feb 1996
01 Feb 1996
publication
A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2
Read more01 Dec 1995
publication
Molecular heterogeneity of progenitors and radial migration in the developing cerebral cortex revealed by transgene expression
Read more01 Dec 1995
publication
Disruption of murine Hexa gene leads to enzymatic deficiency and to neuronal lysosomal storage, similar to that observed in Tay-Sachs disease
Read more01 Sep 1995
publication
Developmental expression of H-2K major histocompatibility complex class I transgenes requires the presence of proximal introns
Read more01 May 1994
publication
Compartmentalization of lambda subtype expression in the B cell repertoire of mice with a disrupted or normal C kappa gene segment
Read more31 Mar 1994
17 Dec 1993
publication
Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain
Read more01 Oct 1992
publication