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© Research
Publication : Molecular and cellular endocrinology

Cell cycle regulation during early mouse embryogenesis

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Molecular and cellular endocrinology - 21 Nov 2007

Artus J, Cohen-Tannoudji M

Link to Pubmed [PMID] – 18164540

Mol. Cell. Endocrinol. 2008 Jan;282(1-2):78-86

Elaboration of a multicellular organism requires highly efficient coordination between proliferation and developmental processes. Accordingly, the embryonic cell cycle exhibits a high degree of plasticity; however, the mechanisms underlying its regulation in vivo remain largely unknown. The purpose of this review is to summarize the data on cell cycle regulation during the early mouse embryonic development, a period characterized by major variations in cell cycle parameters which correlate with important developmental transitions. In particular, we analyse the contribution of mutant mice to the study of in vivo cell cycle regulation during early development and discuss possible contributions of cell cycle regulators to developmental programs.

http://www.ncbi.nlm.nih.gov/pubmed/18164540