Timeline

Alexandre Chenal
Group Leader
20 Dec 2019
event

1st Italian-French-German Joint Meeting on Toxinology

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03 Sep 2019
event

PhD defense of Alexis Voegele: Study of the translocation mechanism of the CyaA toxin from Bordetella pertussis

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21 Jun 2019
publication

Post-translational acylation controls the folding and functions of the CyaA RTX toxin

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13 Feb 2019
publication

The Adenylate Cyclase (CyaA) Toxin from Has No Detectable Phospholipase A (PLA) Activity In Vitro

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03 Jan 2019
event

Department of Structural Biology and Chemistry Department: Paolo de Los Rios, Non-equilibrium protein folding (and unfolding) in the cell.

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20 Jul 2018
publication

Bioengineering of Adenylate Cyclase Toxin for Antigen-Delivery and Immunotherapy

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29 Dec 2017
publication

Calmodulin fishing with a structurally disordered bait triggers CyaA catalysis

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14 Nov 2017
publication

Structural disorder and induced folding within two cereal, ABA stress and ripening (ASR) proteins

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14 Nov 2017
publication

Membrane-Active Properties of an Amphitropic Peptide from the CyaA Toxin Translocation Region

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28 Sep 2017
publication

Synthesis and characterization of tethered lipid assemblies for membrane protein reconstitution (Review)

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26 Jul 2017
publication

Exposure to Bordetella pertussis adenylate cyclase toxin affects integrin-mediated adhesion and mechanics in alveolar epithelial cells

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30 Mar 2017
publication

Bacterial kinesin light chain (Bklc) links the Btub cytoskeleton to membranes

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10 Feb 2017
publication

Stability, structural and functional properties of a monomeric, calcium-loaded adenylate cyclase toxin, CyaA, from Bordetella pertussis

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27 Jan 2017
event

HDX-MS/NMR DAY

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18 Aug 2016
publication

From bulk to plasmonic nanoparticle surfaces: the behavior of two potent therapeutic peptides, octreotide and pasireotide

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18 Aug 2016
publication

Correction: The Translocation Domain of Botulinum Neurotoxin A Moderates the Propensity of the Catalytic Domain to Interact with Membranes at Acidic pH

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13 Jul 2016
publication

MEMHDX: an interactive tool to expedite the statistical validation and visualization of large HDX-MS datasets

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09 May 2016
publication

Molecular Basis of Membrane Association by the Phosphatidylinositol Mannosyltransferase PimA Enzyme from Mycobacteria

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12 Apr 2016
publication

The Translocation Domain of Botulinum Neurotoxin A Moderates the Propensity of the Catalytic Domain to Interact with Membranes at Acidic pH

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25 Mar 2016
publication

The Tip of the Four N-Terminal α-Helices of Clostridium sordellii Lethal Toxin Contains the Interaction Site with Membrane Phosphatidylserine Facilitating Small GTPases Glucosylation

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20 Nov 2015
project

Biophysical characterization of the translocation process of Bordetella pertussis adenylate cyclase toxin CyaA

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20 Nov 2015
publication

Anchoring Sites of Fibrillogenic Peptide Hormone Somatostatin-14 on Plasmonic Nanoparticles.

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18 Nov 2015
project

Molecular crowding

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16 Sep 2015
publication

Structural models of intrinsically disordered and calcium-bound folded states of a protein adapted for secretion

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23 Aug 2015
publication

Structure and function of RTX toxins.

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17 Aug 2015
project

CyaA secretion, folding and translocation across membrane

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04 Aug 2015
publication

Bee venom phospholipase A2 as a membrane-binding vector for cell surface display or internalization of soluble proteins

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21 Jul 2015
project

Development of a new statistical tool for the analysis of large HDX-MS data sets

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16 Jul 2015
team

BiophysiCyaA

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13 May 2015
publication

The catalytic domains of Clostridium sordellii lethal toxin and related large clostridial glucosylating toxins specifically recognize the negatively charged phospholipids phosphatidylserine and phosphatidic acid

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11 May 2015
team

Biochemistry of Macromolecular Interactions

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31 Dec 2014
publication

Disorder-to-order transition in the CyaA toxin RTX domain: implications for toxin secretion

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17 Nov 2014
publication

Secondary structure reshuffling modulates glycosyltransferase function at the membrane

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17 Sep 2014
publication

Calcium, acylation, and molecular confinement favor folding of Bordetella pertussis adenylate cyclase CyaA toxin into a monomeric and cytotoxic form

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25 Jul 2014
publication

Allosteric activation of Bordetella pertussis adenylyl cyclase by calmodulin: molecular dynamics and mutagenesis studies

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02 Dec 2013
publication

Bordetella pertussis adenylate cyclase toxin translocation across a tethered lipid bilayer

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24 Sep 2013
publication

Characterization of a membrane-active peptide from the Bordetella pertussis CyaA toxin

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31 Jul 2013
publication

Molecular crowding stabilizes both the intrinsically disordered calcium-free state and the folded calcium-bound state of a repeat in toxin (RTX) protein

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12 Jan 2012
publication

Identification of a region that assists membrane insertion and translocation of the catalytic domain of Bordetella pertussis CyaA toxin

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01 Jan 2012
publication

Mean net charge of intrinsically disordered proteins: experimental determination of protein valence by electrophoretic mobility measurements

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01 Jan 2012
publication

Estimation of intrinsically disordered protein shape and time-averaged apparent hydration in native conditions by a combination of hydrodynamic methods

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19 Nov 2011
publication

Amyloid fibrils formed by the programmed cell death regulator Bcl-xL

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15 Mar 2011
publication

Calcium-induced folding of intrinsically disordered repeat-in-toxin (RTX) motifs via changes of protein charges and oligomerization states

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01 Dec 2010
publication

Calcium-induced folding and stabilization of the intrinsically disordered RTX domain of the CyaA toxin

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22 Jan 2010
publication

Characterization of the regions involved in the calcium-induced folding of the intrinsically disordered RTX motifs from the bordetella pertussis adenylate cyclase toxin

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19 Jan 2010
publication

Calmodulin-induced conformational and hydrodynamic changes in the catalytic domain of Bordetella pertussis adenylate cyclase toxin

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24 Jul 2009
publication

Clostridium septicum alpha-toxin forms pores and induces rapid cell necrosis

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01 Jul 2009
publication

Deciphering membrane insertion of the diphtheria toxin T domain by specular neutron reflectometry and solid-state NMR spectroscopy

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13 May 2009
publication

Side chain resonances in static oriented proton-decoupled 15N solid-state NMR spectra of membrane proteins

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23 Mar 2009
publication

Cellular functions and X-ray structure of anthrolysin O, a cholesterol-dependent cytolysin secreted by Bacillus anthracis

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17 Nov 2008
publication

RTX calcium binding motifs are intrinsically disordered in the absence of calcium: implication for protein secretion

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07 Aug 2008
publication

Membrane Interaction of botulinum neurotoxin A translocation (T) domain. The belt region is a regulatory loop for membrane interaction

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21 Jun 2007
publication

Concerted protonation of key histidines triggers membrane interaction of the diphtheria toxin T domain

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15 Mar 2007
publication

Type III secretion effectors of the IpaH family are E3 ubiquitin ligases

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13 Feb 2007
publication

Defining the interacting regions between apomyoglobin and lipid membrane by hydrogen/deuterium exchange coupled to mass spectrometry

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24 Jan 2007
publication

Behavior of the N-terminal helices of the diphtheria toxin T domain during the successive steps of membrane interaction

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22 Jan 2007
publication

Interactions of apomyoglobin with membranes: mechanisms and effects on heme uptake

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20 Apr 2006
publication

Structural and functional characterization of an essential RTX subdomain of Bordetella pertussis adenylate cyclase toxin

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17 Jun 2005
publication

Conformational states and thermodynamics of alpha-lactalbumin bound to membranes: a case study of the effects of pH, calcium, lipid membrane curvature and charge

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16 Feb 2005
publication

Characterization of wild-type recombinant Bet v 1a as a candidate vaccine against birch pollen allergy

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30 Sep 2004
publication

Alteration of the tertiary structure of the major bee venom allergen Api m 1 by multiple mutations is concomitant with low IgE reactivity

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13 Aug 2004
publication

Interaction between the two subdomains of the C-terminal part of the botulinum neurotoxin A is essential for the generation of protective antibodies

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01 Jan 2003
publication

Anchoring cytokines to tumor cells for the preparation of anticancer vaccines without gene transfection in mice

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06 Sep 2002
publication

Clostridium perfringens iota toxin. Mapping of the Ia domain involved in docking with Ib and cellular internalization

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21 Aug 2002
publication

Membrane protein insertion regulated by bringing electrostatic and hydrophobic interactions into play. A case study with the translocation domain of diphtheria toxin

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01 May 2002
publication

Does fusion of domains from unrelated proteins affect their folding pathways and the structural changes involved in their function? A case study with the diphtheria toxin T domain

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01 Jun 2001
publication

Prolonged display or rapid internalization of the IgG-binding protein ZZ anchored to the surface of cells using the diphtheria toxin T domain

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01 Jan 2001
publication

[Anchoring cytokines to cancer cells using diphtheria toxin: better than immunotherapy by gene transfer?]

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