Ligne de temps
Alexandre Chenal
Chef(fe) de Groupe
20 nov. 2023
publication
B2LiVe, a label-free 1D-NMR method to quantify the binding of amphitropic peptides or proteins to membrane vesicles.
Lire plus25 mai 2023
23 mars 2023
publication
Gallocin A, an Atypical Two-Peptide Bacteriocin with Intramolecular Disulfide Bonds Required for Activity.
Lire plus08 oct. 2022
publication
A Robust and Sensitive Spectrophotometric Assay for the Enzymatic Activity of Bacterial Adenylate Cyclase Toxins.
Lire plus08 sept. 2022
09 août 2022
publication
Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium.
Lire plus01 mai 2021
publication
A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.
Lire plus15 oct. 2020
publication
Development of Conformational Antibodies to Detect Bcl-xL’s Amyloid Aggregates in Metal-Induced Apoptotic Neuroblastoma Cells.
Lire plus18 août 2020
publication
Dissecting the Structural and Chemical Determinants of the “Open-to-Closed” Motion in the Mannosyltransferase PimA from Mycobacteria.
Lire plus02 avr. 2020
publication
Essential dynamic interdependence of FtsZ and SepF for Z-ring and septum formation in Corynebacterium glutamicum.
Lire plus01 janv. 2020
publication
Hydrogen/Deuterium Exchange Mass Spectrometry for the Structural Analysis of Detergent-Solubilized Membrane Proteins.
Lire plus01 janv. 2020
publication
Functional and structural consequences of epithelial cell invasion by Bordetella pertussis adenylate cyclase toxin.
Lire plus20 déc. 2019
03 sept. 2019
event
PhD defense of Alexis Voegele: Study of the translocation mechanism of the CyaA toxin from Bordetella pertussis
Lire plus21 juin 2019
publication
Post-translational acylation controls the folding and functions of the CyaA RTX toxin.
Lire plus13 févr. 2019
publication
The Adenylate Cyclase (CyaA) Toxin from Bordetella pertussis Has No Detectable Phospholipase A (PLA) Activity In Vitro.
Lire plus03 janv. 2019
event
Department of Structural Biology and Chemistry Department: Paolo de Los Rios, Non-equilibrium protein folding (and unfolding) in the cell.
Lire plus01 nov. 2018
publication
Translocation and calmodulin-activation of the adenylate cyclase toxin (CyaA) of Bordetella pertussis.
Lire plus20 juil. 2018
publication
Bioengineering of Adenylate Cyclase Toxin for Antigen-Delivery and Immunotherapy
Lire plus14 nov. 2017
publication
Structural disorder and induced folding within two cereal, ABA stress and ripening (ASR) proteins
Lire plus14 nov. 2017
publication
Membrane-Active Properties of an Amphitropic Peptide from the CyaA Toxin Translocation Region
Lire plus28 sept. 2017
publication
Synthesis and characterization of tethered lipid assemblies for membrane protein reconstitution (Review)
Lire plus26 juil. 2017
publication
Exposure to Bordetella pertussis adenylate cyclase toxin affects integrin-mediated adhesion and mechanics in alveolar epithelial cells
Lire plus10 févr. 2017
publication
Stability, structural and functional properties of a monomeric, calcium-loaded adenylate cyclase toxin, CyaA, from Bordetella pertussis
Lire plus27 janv. 2017
01 janv. 2017
publication
Calmodulin fishing with a structurally disordered bait triggers CyaA catalysis.
Lire plus18 août 2016
publication
From bulk to plasmonic nanoparticle surfaces: the behavior of two potent therapeutic peptides, octreotide and pasireotide
Lire plus13 juil. 2016
publication
MEMHDX: an interactive tool to expedite the statistical validation and visualization of large HDX-MS datasets.
Lire plus09 mai 2016
publication
Molecular Basis of Membrane Association by the Phosphatidylinositol Mannosyltransferase PimA Enzyme from Mycobacteria.
Lire plus25 mars 2016
publication
The Tip of the Four N-Terminal α-Helices of Clostridium sordellii Lethal Toxin Contains the Interaction Site with Membrane Phosphatidylserine Facilitating Small GTPases Glucosylation
Lire plus20 nov. 2015
project
Biophysical characterization of the translocation process of Bordetella pertussis adenylate cyclase toxin CyaA
Lire plus20 nov. 2015
publication
Anchoring Sites of Fibrillogenic Peptide Hormone Somatostatin-14 on Plasmonic Nanoparticles.
Lire plus18 nov. 2015
16 sept. 2015
publication
Structural models of intrinsically disordered and calcium-bound folded states of a protein adapted for secretion.
Lire plus23 août 2015
17 août 2015
04 août 2015
publication
Bee venom phospholipase A2 as a membrane-binding vector for cell surface display or internalization of soluble proteins
Lire plus21 juil. 2015
16 juil. 2015
13 mai 2015
publication
The catalytic domains of Clostridium sordellii lethal toxin and related large clostridial glucosylating toxins specifically recognize the negatively charged phospholipids phosphatidylserine and phosphatidic acid
Lire plus11 mai 2015
31 déc. 2014
publication
Disorder-to-order transition in the CyaA toxin RTX domain: implications for toxin secretion
Lire plus17 nov. 2014
publication
Secondary structure reshuffling modulates glycosyltransferase function at the membrane.
Lire plus17 sept. 2014
publication
Calcium, acylation, and molecular confinement favor folding of Bordetella pertussis adenylate cyclase CyaA toxin into a monomeric and cytotoxic form
Lire plus25 juil. 2014
publication
Allosteric activation of Bordetella pertussis adenylyl cyclase by calmodulin: molecular dynamics and mutagenesis studies
Lire plus02 déc. 2013
publication
Bordetella pertussis adenylate cyclase toxin translocation across a tethered lipid bilayer
Lire plus24 sept. 2013
publication
Characterization of a membrane-active peptide from the Bordetella pertussis CyaA toxin
Lire plus31 juil. 2013
publication
Molecular crowding stabilizes both the intrinsically disordered calcium-free state and the folded calcium-bound state of a repeat in toxin (RTX) protein
Lire plus12 janv. 2012
publication
Identification of a region that assists membrane insertion and translocation of the catalytic domain of Bordetella pertussis CyaA toxin
Lire plus01 janv. 2012
publication
Mean net charge of intrinsically disordered proteins: experimental determination of protein valence by electrophoretic mobility measurements
Lire plus01 janv. 2012
publication
Estimation of intrinsically disordered protein shape and time-averaged apparent hydration in native conditions by a combination of hydrodynamic methods
Lire plus19 nov. 2011
15 mars 2011
publication
Calcium-induced folding of intrinsically disordered repeat-in-toxin (RTX) motifs via changes of protein charges and oligomerization states
Lire plus01 déc. 2010
publication
Calcium-induced folding and stabilization of the intrinsically disordered RTX domain of the CyaA toxin
Lire plus22 janv. 2010
publication
Characterization of the regions involved in the calcium-induced folding of the intrinsically disordered RTX motifs from the bordetella pertussis adenylate cyclase toxin
Lire plus19 janv. 2010
publication
Calmodulin-induced conformational and hydrodynamic changes in the catalytic domain of Bordetella pertussis adenylate cyclase toxin
Lire plus24 juil. 2009
01 juil. 2009
publication
Deciphering membrane insertion of the diphtheria toxin T domain by specular neutron reflectometry and solid-state NMR spectroscopy
Lire plus13 mai 2009
publication
Side chain resonances in static oriented proton-decoupled 15N solid-state NMR spectra of membrane proteins
Lire plus23 mars 2009
publication
Cellular functions and X-ray structure of anthrolysin O, a cholesterol-dependent cytolysin secreted by Bacillus anthracis
Lire plus17 nov. 2008
publication
RTX calcium binding motifs are intrinsically disordered in the absence of calcium: implication for protein secretion
Lire plus07 août 2008
publication
Membrane Interaction of botulinum neurotoxin A translocation (T) domain. The belt region is a regulatory loop for membrane interaction
Lire plus21 juin 2007
publication
Concerted protonation of key histidines triggers membrane interaction of the diphtheria toxin T domain
Lire plus15 mars 2007
13 févr. 2007
publication
Defining the interacting regions between apomyoglobin and lipid membrane by hydrogen/deuterium exchange coupled to mass spectrometry
Lire plus24 janv. 2007
publication
Behavior of the N-terminal helices of the diphtheria toxin T domain during the successive steps of membrane interaction
Lire plus22 janv. 2007
publication
Interactions of apomyoglobin with membranes: mechanisms and effects on heme uptake
Lire plus20 avr. 2006
publication
Structural and functional characterization of an essential RTX subdomain of Bordetella pertussis adenylate cyclase toxin
Lire plus17 juin 2005
publication
Conformational states and thermodynamics of alpha-lactalbumin bound to membranes: a case study of the effects of pH, calcium, lipid membrane curvature and charge
Lire plus16 févr. 2005
publication
Characterization of wild-type recombinant Bet v 1a as a candidate vaccine against birch pollen allergy
Lire plus30 sept. 2004
publication
Alteration of the tertiary structure of the major bee venom allergen Api m 1 by multiple mutations is concomitant with low IgE reactivity
Lire plus13 août 2004
publication
Interaction between the two subdomains of the C-terminal part of the botulinum neurotoxin A is essential for the generation of protective antibodies
Lire plus13 août 2004
publication
Interaction between the two subdomains of the C-terminal part of the botulinum neurotoxin A is essential for the generation of protective antibodies
Lire plus01 janv. 2003
publication
Anchoring cytokines to tumor cells for the preparation of anticancer vaccines without gene transfection in mice
Lire plus06 sept. 2002
publication
Clostridium perfringens iota toxin. Mapping of the Ia domain involved in docking with Ib and cellular internalization
Lire plus21 août 2002
publication
Membrane protein insertion regulated by bringing electrostatic and hydrophobic interactions into play. A case study with the translocation domain of diphtheria toxin
Lire plus01 mai 2002
publication
Does fusion of domains from unrelated proteins affect their folding pathways and the structural changes involved in their function? A case study with the diphtheria toxin T domain
Lire plus01 juin 2001
publication
Prolonged display or rapid internalization of the IgG-binding protein ZZ anchored to the surface of cells using the diphtheria toxin T domain
Lire plus01 janv. 2001
publication