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© Research

About

Our group studies the basis of human genetic susceptibility to major human pathogens. We focus on two mosquito-borne infections, malaria and dengue, currently impose a heavy public health burden in tropical and sub-tropical areas. Whilst to date, the majority of human genetic studies have focused on genes implicated in severe/fatal disease, a mild or even asymptomatic outcome infection is common. We aim to identify genes governing infection outcome and transmissibility, within two important contexts:

  1. That of the pathogen exploitation of the host and maximization of onward transmission;
  2. The environmental context, placing emphasis upon the exogenous factors that impact upon the within-host dynamic of the pathogen and thus influence the outcome of infection.

An increased appreciation of the importance of gene-gene and gene-environment interactions is necessary to understand the full extent to which genetics underlie infection outcome.

 

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Role of T and B cells in long lasting immunity against dengue

Building: bâtiment Monod – Room: Amphi. Jacques Monod – Address: Institut Pasteur, Paris, France
2018-05-30 13:30:00 2018-05-30 16:30:00 Europe/Paris Role of T and B cells in long lasting immunity against dengue Abstract Zika virus (ZIKV) is an emerging virus of the Flaviviridae family, transmitted by Aedes species mosquitoes. The high level of dengue virus (DENV) seroprevalence in areas where ZIKV is circulating and the immunological […] Institut Pasteur, Paris, France

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Phone: 33 1 44 38 91 03
Email: anavaj@pasteur.fr

Address
25-28 Rue du Docteur Roux
75015, Paris
France