Mouse models for Covid-19
Mice are not naturally susceptible to SARS-CoV-2 due to poor binding of the virus spike to the mouse cellular receptor ACE2. We have developed a mouse-adapted strain of SARS-CoV-2 which efficiently replicates in the […]
Study of immune crosstalk in COVID-19 COVIMUNE
Our overall goal is to understand the cellular and molecular aspects of immune response to SARS-CoV-2 virus in terms of activation of over-reactive immunity and induction of immune protection. COVIMUNE is designed to target […]
miRNA involvement in resistance to infection by Dengue virus : miRNA transcriptome on monocytes of individuals “Susceptible” or “Resistant” following in vitro infection by DENV2
We performed miRNome on monocytes from healthy donors living in Bangkok, previously checked for their antibodies against DENV. We hypothesized that individuals without antibodies against any serotype of DENV may represent a DENV-resistant population, […]
Analyzing SKAP2 Interactome to pinpoint its Functions
The SRC Kinase Adaptor Phosphoprotein 2 (SKAP2), a broadly expressed protein recruiting protein partners to specific subcellular domains, plays a central role in multiple processes including TGFb response, integrin signalling, and cell migration. It […]
T cell immunity to dengue virus infection in transgenic mice expressing human HLA molecules
Based on the recent identification of the non-structural proteins NS3, NS4B and NS5 of dengue virus (DENV) as the main targets for T cell responses in humans, we have designed a minimal DENV antigen, […]
2021A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters, Nat Commun . 2021 Nov 1;12(1):6277.
2019A Modified mRNA Vaccine Targeting Immunodominant NS Epitopes Protects Against Dengue Virus Infection in HLA Class I Transgenic Mice, Front. Immunol. 2019 Jun;10 (1424).