Marcel Hollenstein, hailing from Lutry (Switzerland), studied chemistry at the University of Lausanne (Switzerland) where he obtained a diploma in 1999. He then moved to the group led by Prof. Christian Leumann at the University of Bern (Switzerland) for his PhD, obtained in 2004. During his PhD, he synthesized fluorinated peptide nucleic acids (PNA) with the aim of investigating structural key features of these important DNA analogs. In 2005, he moved to the group of Prof. David Perrin at the University of British Columbia (Vancouver, Canada) for a postdoctoral stay. During this time, he was involved in Darwinian selection experiments (SELEX) to generate chemically modified DNA enzymes capable of cleaving RNA targets in the absence of divalent metal co-factors. In 2009, Marcel moved back to Bern (in the group of Prof. Christian Leumann) with a grant from the Swiss National Science Foundation (Ambizione fellowship) to work on independent research projects that dealt with the synthesis and biochemical characterization of modified nucleoside triphosphates for their futher use in the development of aptamers, DNA enzymes, and bionanomaterials. In January 2016, he was offered a position at the Institut Pasteur (Paris, France) to lead a 5-year junior group ‘bioorganic chemistry of nucleic acids’ in the department of structural biology and chemistry.
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2021Stealth Fluorescence Labeling for Live Microscopy Imaging of mRNA Delivery, J. Am. Chem. Soc. 2021, 143, 5413−5424.
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2020Enzymatic Formation of an Artificial Base Pair Using a Modified Purine Nucleoside Triphosphate, ACS Chem. Biol. 2020, 15, 2872-2884.
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2020Enzymatic Construction of Artificial Base Pairs: The Effect of Metal Shielding, ChemBioChem 2020, 21, 3398-3409.
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2020Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker., Proc. Natl. Acad. Sci. U.S.A. 2020 Jul; (): .
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2020Orthogonal Genetic Systems, ChemBioChem 2020, 21, 1408-1411.
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2020Enzymatic synthesis of biphenyl-DNA oligonucleotides, Biorg. Med. Chem. 2020, 28, 115487.
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2020Self‐Assembly of DNA and RNA Building Blocks Explored by Nitrogen‐14 NMR Crystallography: Structure and Dynamics, ChemPhysChem 2020, 21, 1044-1051.
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2020Ruthenium-initiated polymerization of lactide: a route to remarkable cellular uptake for photodynamic therapy of cancer, Chem. Sci., 2020, 11, 2657-2663.
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2019Enzymatic Formation of an Artificial Base Pair Using a Modified Adenine Nucleoside Triphosphate, ChemRxiv 2019, doi: 10.26434/chemrxiv.11427459.v1.
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2019On the Enzymatic Formation of Metal Base Pairs with Thiolated and pKa-Perturbed Nucleotides, ChemBioChem 2019, 20, 3032 – 3040.
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