Marcel Hollenstein, hailing from Lutry (Switzerland), studied chemistry at the University of Lausanne (Switzerland) where he obtained a diploma in 1999. He then moved to the group led by Prof. Christian Leumann at the University of Bern (Switzerland) for his PhD, obtained in 2004. During his PhD, he synthesized fluorinated peptide nucleic acids (PNA) with the aim of investigating structural key features of these important DNA analogs. In 2005, he moved to the group of Prof. David Perrin at the University of British Columbia (Vancouver, Canada) for a postdoctoral stay. During this time, he was involved in Darwinian selection experiments (SELEX) to generate chemically modified DNA enzymes capable of cleaving RNA targets in the absence of divalent metal co-factors. In 2009, Marcel moved back to Bern (in the group of Prof. Christian Leumann) with a grant from the Swiss National Science Foundation (Ambizione fellowship) to work on independent research projects that dealt with the synthesis and biochemical characterization of modified nucleoside triphosphates for their futher use in the development of aptamers, DNA enzymes, and bionanomaterials. In January 2016, he was offered a position at the Institut Pasteur (Paris, France) to lead a 5-year junior group ‘bioorganic chemistry of nucleic acids’ in the department of structural biology and chemistry.
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2022Evaluation of 3′-phosphate as a transient protecting group for controlled enzymatic synthesis of DNA and XNA oligonucleotides, Commun. Chem. 2022, 5, 68.
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2022Towards polymerase-mediated synthesis of artificial RNA–DNA metal base pairs, New J. Chem., 2022, 46, 4871-4876.
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2022A ruthenium-oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy, RSC Chem. Biol., 2022, 3, 85-95.
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2021Polymerase-mediated synthesis of artificial RNA-DNA metal base pairs, ChemRxiv 2021, 10.26434/chemrxiv-2021-2d0h6.
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2021A ruthenium-oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy, RSC Chemical Biology.
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2021A ruthenium-oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy, ChemRxiv 2021, 10.33774/chemrxiv-2021-5n9xv.
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2021Towards the enzymatic synthesis of phosphorothioate containing LNA oligonucleotides, Bioorg. Med. Chem. Lett. 48 (2021) 128242.
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2021Enzymatic construction of metal-mediated nucleic acid base pairs, Metallomics, 2021, 13, mfab016.
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2021Recent progress in non-native nucleic acid modifications, Chem. Soc. Rev. 2021, 50, 5126–5164.
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2021Stealth Fluorescence Labeling for Live Microscopy Imaging of mRNA Delivery, J. Am. Chem. Soc. 2021, 143, 5413−5424.
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