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  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
04
Jan 2016
Ending Date
01
Jan 2021
Status
Ongoing
Members
4
Structures
2
Publications
3

About

Functional nucleic acids (aptamers, DNAzymes, ribozymes, and aptazymes) are generated by in vitro Darwinian evolution methods (SELEX and related methods of in vitro selection). We are interested to expand the capacity of these functional nucleic acids in terms of nuclease resistance, binding capacity, catalytic activity, and scope. An interesting method to improve the capacity of functional nucleic acids is to include modified nucleoside triphosphates (dN*TPs) into the selection experiments. Thus, an important project of the laboratory consists in the chemical synthesis and biochemical characterization of dN*TPs with modifications of the nucleobase and the sugar unit. This will allow for the exploration of larger chemical spaces in selection experiments.

Fundings

References