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  • Deputy Director of National Reference Center
  • Director of Center
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Scientific Fields
Diseases
Organisms
Applications
Technique

Projects

project
Ongoing
4 Members

Expansion of the genetic alphabet with metal base pairs

Marcel Hollenstein (PI)

Expanding the genetic code beyond the A-T/G-C Watson-Crick canonical base pairs and 20 amino acids of natural organisms is a long standing goal in synthetic biology. Reprogrammation of the genetic code can lead to […]
project
Ongoing
5 Members

Therapeutic tools based on nucleic acids

Marcel Hollenstein (PI)

An important research axis of the laboratory is to modify nucleic acids with chemical groups in order to improve their therapeutic usefulness. Particularly, modified aptamers (i.e. oligonucleotides capable of binding to targets with high […]
project
Ongoing
4 Members

Synthesis of chemically modified nucleoside triphosphates

Marcel Hollenstein (PI)

Functional nucleic acids (aptamers, DNAzymes, ribozymes, and aptazymes) are generated by in vitro Darwinian evolution methods (SELEX and related methods of in vitro selection). We are interested to expand the capacity of these functional […]

Publications

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