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Production of Custom Micropatterns for Cell Culture
We provide an integrated solution for the design and fabrication of micropatterns. This service based on the local functionalization of cell culture substrates with extracellular matrix components or other proteins.
Organ-on-Chip Technology – Emulate
Organ-on-Chip center The center is equipped with Emulate technology (multiple Zoé and Orbs) Multiple Organ mimics are available (Intestine, Liver, kidney, Lung…). Experiments can be performed in BSL2 and BSL3 conditions. The center is […]
Design and Production of Microfluidic Devices
The Biomaterials and Microfluidics core facility is fully geared for the design, production and testing of microfluidic devices. The team will provide expertise, protocols and equipment to allow users to produce “homemade” chips.
Advanced 3D Cell Culture Systems
We provide a library of 3D cell culture scaffolds with tunable biophysical and biochemical properties.
Équipements
Booking site UV/Ozone cleaner • Jelight • UVO Cleaner
This machine is used for sterilizing microfluidic chips, creating micropatterns on glass coverslips or as a source of UV for photopolymerization
Rheometer • Malvern • Kinexus Ultra+
This machine is dedicated to the measurement of the mechanical properties of different materials. 20 and 4 mm geometries are available.
PDMS • Station • Thinky
This station is equipped with a automated mixer, degassing bottles, a balance a couple of ovens
Stylus Profiler • Bruker • DektakXT
A machine for measuring the height and the roughness of microfabricated structures. Range: 0.1 to 500 micron.
Computational fluid dynamics simulation • Software • COMSOL Multiphysics
A software dedicated to finite element simulation of the all the physical parameters that can occur in a microfluidic chip (flow, shear stress, diffusion, gradient formation….)
2 • Microfluidic syringe pumps • Cetoni • neMESYS
Computer controlled (programmable) syringe pump system dedicated to microfluidic chip perfusion. One controller plus two low pressure modules and a pressure sensor.
Inverted microscope for live cell imaging • Zeiss • Axiovert
Inverted microscope for live cell imaging capabilities. The microscope is built for speed in order to reduce the interval between time points when acquiring a timelapse experiment. Standard LED fluorescence is available (Colibri system). […]
Membres
Samy Gobaa
Responsable de Plateforme
Responsable
Anciens Membres
2000
2000
Name
Position
2016
2020
Raphaël Gayet
Visiting Scientist
2016
2020
Yasemin Atiyas
Undergraduate Student
2016
2020
Camille Berthault
2016
2020
Igor Molybog
Undergraduate Student
2016
2020
Stefan Rouach
Undergraduate Student
2016
2020
Charlotte Bouquerel
Graduate Student
2016
2020
Anette Funfak
Post-doc
Projets
Financements
Publications
Télécharger-
2021Microfabricated Device for High-Resolution Imaging of Preimplantation Embryos., Methods Mol. Biol. 2021 ; 2214(): 11-30.
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2020Aggregation Temperature of Escherichia coli Depends on Steepness of the Thermal Gradient, Biophys. J. 2020 Apr;.
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2019Biophysical Control of Bile Duct Epithelial Morphogenesis in Natural and Synthetic Scaffolds, Front Bioeng Biotechnol 2019;7:417.
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2019Biophysical Control of Bile Duct Epithelial Morphogenesis in Natural and Synthetic Scaffolds, Front. Bioeng. Biotechnol. 7:417.
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2019Bioengineered Human Organ-on-Chip Reveals Intestinal Microenvironment and Mechanical Forces Impacting Shigella Infection, Cell Host Microbe 2019 Sep;26(3):435-444.e4.
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2018Artificial niche microarrays for identifying extrinsic cell-fate determinants, Methods in Cell Biology Volume 148, 2018, Pages 51-69.
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2017A tuneable microfluidic system for long duration chemotaxis experiments in a 3D collagen matrix, Lab Chip 2017 Nov;17(22):3851-3861.
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2016Controlled production of sub-millimeter liquid core hydrogel capsules for parallelized 3D cell culture, Lab Chip 2016 12;17(1):110-119.
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2015Paramecium swimming and ciliary beating patterns: a study on four RNA interference mutations, Integr Biol (Camb) 2015 Jan;7(1):90-100.
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2013Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro, Proc. Natl. Acad. Sci. U.S.A. 2013 Sep;110(37):14843-8.
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+Voir la liste complète de publications
Contact
Phone: +33 1 44 38 92 75 Email: bmcf@pasteur.fr; samy.gobaa@pasteur.fr Address: 25-28 Rue du Docteur Roux 75015, Paris France