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Disease-on-Chip: Interconnecting Microfluidic Devices to Study Meningococcal Infection
Biomaterials & Microfluidics (S. Gobaa) Pathogenesis of vascular infections (G. Duménil) The project Both the Biomaterials & Microfluidics core facility and the Pathogenesis of Vascular Infections unit at Institut Pasteur are joining efforts in […]
Samy Gobaa (PI)
What’s best to study humans and their infectious deseases than Human emulation system ? It’s now possible at Pasteur to develop real Organs-on-chips with cells from different sources, patient derived or cell line. At […]
Samy Gobaa (PI)
The goals of this project are to build an external bioartificial liver, a liver-on-chip as well as a bioengineered liver. In the present project, bioconstruction of the liver will be performed by the assembly […]
Samy Gobaa (PI)
Welcome to the club! Welcome to Microfluidics@Pasteur! Our goal is to serve as the major entry point to all the scientists on the campus (beginners and experts) interested in undertaking projects where microfluidics is involved. Our […]
Organ-on-chip center Working with Emulate technology Design your Organ (Intestine, Liver, Lungs, Brain, Lymphoid organs…)
BMcf is fully geared towards meeting the need in term of microfluidic chip design and production. The team will provide expertise, protocols and equipment to allow the interested scientists to produce “homemade” microfluidic devices.
We provide a library of 3D cell culture scaffolds with tunable biophysical and biochemical properties.
The pipeline is targeted for the production of microfluidics chips in PDMS (silicone elastomer) . Masters produced by contact photolithography are (negatively) replicated in PDMS under dust-free conditions. The bonding of the chips are performed […]
The photolithography station is dedicated to microfabrication applications. The concept is based on the using 1-UV light, 2-Binary masks and 3-photosensitive resins to produce 3D objects with resolution <1μm.
Computer controlled (programmable) syringe pump system dedicated to microfluidic chip perfusion. One controller plus two low pressure modules and a pressure sensor.
Inverted microscope for live cell imaging capabilities. The microscope is built for speed in order to reduce the interval between time points when acquiring a timelapse experiment. Standard LED fluorescence is available (Colibri system). […]
Oxygen plasma cleaner. Applications: surface activation, PDMS bonding, cleaning. Controllable vacuum, gas injection, power, treatment time.
2018Artificial niche microarrays for identifying extrinsic cell-fate determinants, Methods in Cell Biology Volume 148, 2018, Pages 51-69.
2017A tuneable microfluidic system for long duration chemotaxis experiments in a 3D collagen matrix, Lab Chip 2017 Nov;17(22):3851-3861.
2016Controlled production of sub-millimeter liquid core hydrogel capsules for parallelized 3D cell culture, Lab Chip 2016 12;17(1):110-119.
2015Paramecium swimming and ciliary beating patterns: a study on four RNA interference mutations, Integr Biol (Camb) 2015 Jan;7(1):90-100.
2013Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro, Proc. Natl. Acad. Sci. U.S.A. 2013 Sep;110(37):14843-8.
2010Synergistic effects of metal nanoparticles and a phenolic uncoupler using microdroplet-based two-dimensional approach, J Environ Monit 2011 Feb;13(2):410-5.
2007Micro fluid segment technique for screening and development studies on Danio rerio embryos, Lab Chip 2007 Sep;7(9):1132-8.
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(EN) Lab news
> 04-01-2019: Héloïse Mary has joined the team. She will reinforce our Organ-on-Chip activities. Bienvenue Héloïse !
> 12-19-2018: We have an open position for a talented Postdoc on a Disease-on-Chip project:
> 08-31- 2018 : Nicolas Minier has joined the lab. He is starting a PhD on Hydrogels as force transducers
Phone: Email: Address 25-28 Rue du Docteur Roux 75015, Paris France