Our Unit investigates new pathways and mechanisms involved in the pathogenesis of low GC % Gram-positive bacteria focusing on the major human pathogens Streptococcus agalactiae and Staphylococcus aureus. We also study the emerging pathogen Streptoccus gallolyticus, a cause of septicemia and infective endocarditis in the elderly, which has been consistently linked to colorectal cancer (CRC). Our research topics include the study of i) the relationship between metabolism and virulence, ii) the function of bacterial proteins involved in the interaction with the host, iii) the regulation of virulence gene expression and the adaptation to stressfull environmental conditions, and iv) the genomic diversity and the evolution of pathogens. The “Biology of Gram-positive Pathogens” Unit created in January 2004 is associated with the CNRS « UMR2001 » and is member of the Labex “Integrative Biology of Emerging Infectious Diseases” since 2012.
Members
Groups

Group : Patrick Trieu-Cuot


Group: Shaynoor Dramsi


Group: Signaling and Pathogenesis of Staphylococci
