Directeur de Recherche, CNRS
Dr. OCHSENBEIN Françoise – “Inhibiting Chromatin Assembly by Targeting Histone Chaperones”
Developement of inhibitors targeting the protein synthesis machinery of Trypanosomatids
Pathogenic protozoans of the trypanosomatid group still remain a major world health problem. Cycling between insect vectors and mammalian hosts, Trypanosoma cruzi is the causative agent of Chagas disease, while over 20 Leishmania species […]
ViBrANT (Viral and Bacterial Adhesin Network Training)
The Innovative Training Network ViBrANT (Viral and Bacterial Adhesin Network Training) brings together world-leading European scientists to train 15 graduate students (early stage researchers) in interdisciplinary research into viral and bacterial adhesins. ViBrANT is […]
Binding mode of promising antituberculosis clinical compounds to their bacterial target
New therapeutic strategies are needed to combat the pandemics and the spread of multidrug resistant form of tuberculosis. This collaborative project between our group and Institut Pasteur of Korea aims to decipher the molecular […]
Type IV pili and pseudopili: structure, dynamics, assembly and molecular function Type IV pili and pseudopili assembled by type 2 secretion systems (T2SS) are thin dynamic fibers that perform diverse functions, from adherence, motility, […]
Bacterial Transmembrane Signaling
Bacteria display several mechanisms to adapt to their host-environment and successfully colonise it. One important mechanism of adaptation concerns the regulation of gene expression in response to external signals such as the presence of […]
2017Structure of the calcium-dependent type 2 secretion pseudopilus, Nat Microbiol. 2017 Oct 9. doi: 10.1038/s41564-017-0041-2. [Epub ahead of print].
20171H, 15N and 13C resonance assignments and secondary structure of PulG, the major pseudopilin from Klebsiella oxytoca type 2 secretion system., Biomol NMR Assign. 2017 Mar 3. doi: 10.1007/s12104-017-9738-7. [Epub ahead of print].
2016Structural basis of the signaling through a bacterial membrane receptor HasR deciphered by an integrative approach., Biochem J. 2016 May 13. pii: BCJ20160131.
2015A tribute to Cécile Wandersman, Res. Microbiol. 2015 Jun;166(5):393-8.
2014Interaction of a partially disordered antisigma factor with its partner, the signaling domain of the TonB-dependent transporter HasR, PLoS ONE 2014;9(4):e89502.
2013The structure of HasB reveals a new class of TonB protein fold, PLoS ONE 2013;8(3):e58964.
2012¹H, ¹⁵N and ¹³C resonance assignments of PpdD, a type IV pilin from enterohemorrhagic Escherichia coli, Biomol NMR Assign 2014 Apr;8(1):43-6.
2012Role of the iron axial ligands of heme carrier HasA in heme uptake and release, J. Biol. Chem. 2012 Aug;287(32):26932-43.
2012(1)H, (13)C and (15)N resonance assignments of the periplasmic signalling domain of HasR, a TonB-dependent outer membrane heme transporter, Biomol NMR Assign 2013 Apr;7(1):43-6.
2009Mapping the interaction between the hemophore HasA and its outer membrane receptor HasR using CRINEPT-TROSY NMR spectroscopy, J. Am. Chem. Soc. 2009 Feb;131(5):1736-44.
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