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Impact of gut mechanical forces and 3D architecture on the intestine homeostasis during pathogen interaction and in cancer disease
Nathalie Sauvonnet (PI)
The intestine, and in particular the colon, comprising a mucus blanket, an epithelial monolayer and the lamina propria rich in immune cells, is constantly subjected to shear stress (flow) and peristaltic motion (stretching), both […]
2020Fermentation Products of Commensal Bacteria Alter Enterocyte Lipid Metabolism, Cell Host Microbe 2020 March 11;27:1-18.
2020Innate immune receptor NOD2 mediates LGR5 intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation, Proc. Natl. Acad. Sci. U.S.A. 2020 Jan;117(4):1994-2003.
2019DNA Hypermethylation Downregulates Telomerase Reverse Transcriptase (TERT) during -Induced Chronic Inflammation, J Oncol 2019;2019:5415761.
2019Intracellular offspring released from SFB filaments are flagellated, Nat Microbiol 2020 Jan;5(1):34-39.
2019Decrypting the communication between microbes and the intestinal mucosa-A brief review on Pathogénie Microbienne Moléculaire’s latest research, Cell. Microbiol. 2019 Nov;21(11):e13118.
2019Mapping of Shigella flexneri’s tissue distribution and type III secretion apparatus activity during infection of the large intestine of guinea pigs, Pathog Dis 2019 10;77(7).
2019Shigella-mediated oxygen depletion is essential for intestinal mucosa colonization, Nat Microbiol 2019 11;4(11):2001-2009.
2019promotes major alteration of gut epithelial physiology and tissue invasion by shutting off host intracellular transport, Proc. Natl. Acad. Sci. U.S.A. 2019 Jul;116(27):13582-13591.
2018Stress-induced host membrane remodeling protects from infection by non-motile bacterial pathogens, EMBO J. 2018 12;37(23).
2018Disentangling Host-Microbiota Regulation of Lipid Secretion by Enterocytes: Insights from Commensals and, mBio 2018 09;9(5).
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