Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Jan 2016
Ending Date
31
Dec 2020
Status
Ongoing
Members
5
Structures
2

About

ILCs are early effectors of immunity and provide a means to rapidly respond to infection or inflammation, and are distinguished from T and B cells of the adaptive immune response. Three groups of ILCs are now described: ILC1, ILC2 and ILC3. ILC1 consists of NK cells and other interferon-g producing innate lymphocytes characterized by expression of the transcription factors T-bet and/Eomes. ILC2 secrete ‘TH2-like’ cytokines under the control of the transcription factors GATA-3 and RORa. ILC3 includes several phenotypically distinct cells that express and require the transcription factor RORgt in order to produce notably the cytokines IL-17 and IL-22. These ILC subsets have been implicated in a wide range of physiological processes including tissue homeostasis and repair, immune defense or development of lymphoid organs. 

In this project, we aim to understand the signals that regulate human ILC development from hematopoietic precursors. We utilise both in vitro culture techniques (bulk and single cell cloning) as well as innovative in vivo approaches (humanized mice) to study this process. Our recent results identify a systemically distributed human ILC precursor that can give rise to all ILC subsets, including cytotoxic NK cells. Furthermore, environmental signals condition ILC differentiation, resulting in substantial functional plasticity. These observations suggest that manipulation of ILC subsets in human disease settings may be of therapeutic benefit.

References

Lim, A.I., Verrier, T., Vosshenrich, C.A.J. and Di Santo, J.P. (2017) Developmental options and functional plasticity of innate lymphoid cells. Current Opinion in Immunology

Lim, A.-I., Menegatti, S., Bustamante, J., Le Bourhis, L., Allez, M., Rogge, L., Casanova, J.-L., Yssel, H. and Di Santo, J.P. (2016) IL-12 drives functional plasticity of human group 2 innate lymphoid cells. Journal of Experimental Medicine 213:569-583.