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Connections
Members
Former Members
2000
2000
Name
Position
2016
2016
Yann Le Guen
PhD Student
2016
2016
Caroline Ligeour
Post-doc
2016
2016
Julie Paoletti
Research Engineer
2016
2016
Hélène Pfister
PhD Student
2016
2016
Zhaoyu Hu
Projects
Transversal Project
Patents
Fundings
Publications
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2022The First-in-Human Synthetic Glycan-Based Conjugate Vaccine Candidate against Shigella., ACS Cent Sci 2022 Apr; 8(4): 449-460.
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2022Toward a Multivalent Synthetic Oligosaccharide-Based Conjugate Vaccine against Shigella: State-of-the-Art for a Monovalent Prototype and Challenges., Vaccines (Basel) 2022 Mar; 10(3): .
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2022Combination of High-Resolution Multistage Ion Mobility and Tandem MS with High Energy of Activation to Resolve the Structure of Complex Chemoenzymatically Synthesized Glycans., Anal Chem 2022 02; 94(4): 2279-2287.
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2021Computer-aided engineering of a branching sucrase for the glucodiversification of a tetrasaccharide precursor of S. flexneri antigenic oligosaccharides., Sci Rep 2021 10; 11(1): 20294.
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2021Safety and immunogenicity of a synthetic carbohydrate conjugate vaccine against Shigella flexneri 2a in healthy adult volunteers: a phase 1, dose-escalating, single-blind, randomised, placebo-controlled study., Lancet Infect Dis 2021 04; 21(4): 546-558.
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2021Exploratory N-Protecting Group Manipulation for the Total Synthesis of Zwitterionic Shigella sonnei Oligosaccharides., Chemistry 2021 Mar; 27(18): 5694-5711.
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2021Convergent Chemoenzymatic Strategy to Deliver a Diversity of Shigella flexneri Serotype-Specific O-Antigen Segments from a Unique Lightly Protected Tetrasaccharide Core., J Org Chem 2021 02; 86(3): 2058-2075.
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2021Redirecting substrate regioselectivity using engineered ΔN123-GBD-CD2 branching sucrases for the production of pentasaccharide repeating units of S. flexneri 3a, 4a and 4b haptens., Sci Rep 2021 01; 11(1): 2474.
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2019Classical and novel strategies to develop a Shigella glycoconjugate vaccine: from concept to efficacy in human., Hum Vaccin Immunother 2019 ; 15(6): 1338-1356.
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2018ADP-heptose is a newly identified pathogen-associated molecular pattern of Shigella flexneri., EMBO Rep 2018 12; 19(12): .
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Contact
Phone: +33 1 40 61 38 20
Email: laurence.mulard@pasteur.fr
Address: Unité de Chimie des Biomolécules, Institut Pasteur, 25-28 Rue du Docteur Roux 75015, Paris France