Role of platelets and their interactions in allergic diseases
Role of platelets and their interactions in allergic diseases that aims at understanding how platelets induce/promote/regulate antibody-induced allergic diseases, their interaction partners (myeloid cells, endothelium) and their dynamics.
Clinical and pathological consequences of human anti-drug antibodies (NASA study)
Clinical and pathological consequences of human anti-drug antibodies (NASA study) that aims at demonstrating in the clinic that neutrophils are activated by antibody-curare complexes and involved in curare-induced anaphylaxis (allergic shock) in humans, and […]
ERC-2013-CoG – 616050_MyeloSHOCK – Role of myeloid cells, their mediators and their antibody receptors in allergic shock (anaphylaxis) using humanized mouse models and clinical samples
Anaphylaxis is a hyperacute allergic reaction of increasing incidence that can be of fatal consequence and that has no specific treatment. Anaphylaxis is thought to rely on mechanisms involving mast cells that bear allergen-specific […]
1,000 healthy donors
The Milieu Intérieur Consortium has established a 1000-person healthy population-based study (stratified according to sex and age), creating an unparalleled opportunity for assessing the determinants of human immunologic variance. The Milieu Intérieur Consortium initiated […]
Use of microfluidic approaches to study Neutrophil Extracellular Trap formation
Netosis consists of the ejection of DNA filaments by activated neutrophils resulting in extracellular DNA (Neutrophil Extracellular Traps, NETs). This DNA has antimicrobial properties but is also toxic to surrounding tissues. NETs have recently […]
2022Current research and unmet needs in allergy and immunology in Germany: report presented by the DGfI and DGAKI task force Allergy & Immunology, Eur J Immunol . 2022 Jun;52(6):851-855.
2022The role of neutrophils in antibody-driven autoimmune cytopenias., Int J Biochem Cell Biol 2022 Jun; 147(): 106231.
2022Specificity of mouse and human Fcgamma receptors and their polymorphic variants for IgG subclasses of different species., Eur J Immunol 2022 Feb; (): .
2021Platelet FcγRIIA-induced serotonin release exacerbates the severity of Transfusion-Related Acute Lung Injury in mice, Blood Adv. 2021 Sep 14;bloodadvances.2021004336.
2021Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome, J Exp Med. 2021 Oct 4;218(10):e20201466. doi: 10.1084/jem.20201466.
2021The role of IgG subclasses and platelets in experimental anaphylaxis., J Allergy Clin Immunol 2021 Jan; (): .
2020Cofilin1-driven Actin Dynamics Controls Migration of Thymocytes and Is Essential for Positive Selection in the Thymus, J Cell Sci. 2020 Mar 6;133(5):jcs238048..
2020Human IgA binds a diverse array of commensal bacteria, J. Exp. Med. 2020 Mar;217(3).
2020Mouse Models and Tools for the in vivo Study of Neutrophils., Front Immunol. 2020 Jan 21;10:3130..
2019Expression, Role, and Regulation of Neutrophil Fcγ Receptors., Front Immunol. 2019 Aug 27;10:1958. Review..
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