ERC-2013-CoG – 616050_MyeloSHOCK – Role of myeloid cells, their mediators and their antibody receptors in allergic shock (anaphylaxis) using humanized mouse models and clinical samples
Anaphylaxis is a hyperacute allergic reaction of increasing incidence that can be of fatal consequence and that has no specific treatment. Anaphylaxis is thought to rely on mechanisms involving mast cells that bear allergen-specific […]
DROPmAbs – Deep-mining of antibody repertoires using droplet-based microfluidics combined with barcoded deep sequencing for diagnostics and therapeutic antibody discovery
In this project we propose to combine ultrahigh-throughput screening of primary B cells using droplet based microfluidics with next-generation sequencing to profile entire B cell antibody repertoires. This process will enable highly-efficient and rapid […]
Role of platelets and their interactions in allergic diseases
Role of platelets and their interactions in allergic diseases that aims at understanding how platelets induce/promote/regulate antibody-induced allergic diseases, their interaction partners (myeloid cells, endothelium) and their dynamics.
Antibody-based anti-tumor immunotherapy
Antibody-based anti-tumor immunotherapy that aims at identifying the human FcγRs involved in melanoma and/or breast cancer immunotherapy, and at identifying the effector population(s) responsible for tumor destruction
2018Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis., Sci Immunol. 2018 Apr 13;3(22). .
2016IgG subclasses determine pathways of anaphylaxis in mice, J. Allergy Clin. Immunol. 2017 01;139(1):269-280.e7.
2015Recognition of core-derived epitopes from a novel HBV-targeted immunotherapeutic by T-cells from patients infected by different viral genotypes, Vaccine 2015 Aug;33(36):4548-53.
2014TG1050, an immunotherapeutic to treat chronic hepatitis B, induces robust T cells and exerts an antiviral effect in HBV-persistent mice, Gut 2014 Nov;.