Clinical and pathological consequences of human anti-drug antibodies (NASA study)
Clinical and pathological consequences of human anti-drug antibodies (NASA study) that aims at demonstrating in the clinic that neutrophils are activated by antibody-curare complexes and involved in curare-induced anaphylaxis (allergic shock) in humans, and […]
Role of platelets and their interactions in allergic diseases
Role of platelets and their interactions in allergic diseases that aims at understanding how platelets induce/promote/regulate antibody-induced allergic diseases, their interaction partners (myeloid cells, endothelium) and their dynamics.
Use of microfluidic approaches to study Neutrophil Extracellular Trap formation
Netosis consists of the ejection of DNA filaments by activated neutrophils resulting in extracellular DNA (Neutrophil Extracellular Traps, NETs). This DNA has antimicrobial properties but is also toxic to surrounding tissues. NETs have recently […]
ERC-2013-CoG – 616050_MyeloSHOCK – Role of myeloid cells, their mediators and their antibody receptors in allergic shock (anaphylaxis) using humanized mouse models and clinical samples
Anaphylaxis is a hyperacute allergic reaction of increasing incidence that can be of fatal consequence and that has no specific treatment. Anaphylaxis is thought to rely on mechanisms involving mast cells that bear allergen-specific […]
1,000 healthy donors
The Milieu Intérieur Consortium has established a 1000-person healthy population-based study (stratified according to sex and age), creating an unparalleled opportunity for assessing the determinants of human immunologic variance. The Milieu Intérieur Consortium initiated […]
2019An IgG-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis, Sci Transl Med. 2019 Jul 10: Vol. 11, Issue 500, eaat1479 DOI: 10.1126/scitranslmed.aat1479 .
2018Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis., Sci Immunol. 2018 Apr 13;3(22). .
2018MUB Binds to Lactoferrin and Stands as a Specific Neutrophil Marker, Cell Chem Biol 2018 Apr;25(4):483-493.e9.
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