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The tumor stromal microenvironment
Lucie Peduto (PI)
Tumor progression, invasion and ultimately metastasis result from interactions between cancer cells and their supporting stromal microenvironment. The tumor stromal microenvironment share many similarities with fibrotic stroma and comprises extracellular matrix components, as well […]
2023Stromal regulation of the intestinal barrier., Mucosal Immunol 2023 Jan: S1933-0219(23)00006-5.
2022PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms., Cell Stem Cell 2022 May; 29(5): 856-868.e5.
2018The perivascular origin of pathological fibroblasts, J. Clin. Invest. 2018 01;128(1):54-63.
2016B cells promote tumor progression in a mouse model of HPV-mediated cervical cancer, Int. J. Cancer 2016 Sep;139(6):1358-71.
2015ATM kinase sustains HER2 tumorigenicity in breast cancer, Nat Commun 2015;6:6886.
2015Sema6A and Mical1 control cell growth and survival of BRAFV600E human melanoma cells, Oncotarget 2015 Feb;6(5):2779-93.
2012Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells, Cell Death Dis 2012;3:e440.
2012Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury, Nat. Med. 2012 Aug;18(8):1262-70.
2009Negative regulation of beta4 integrin transcription by homeodomain-interacting protein kinase 2 and p53 impairs tumor progression, Cancer Res. 2009 Jul;69(14):5978-86.
2008Induction of ErbB-3 expression by alpha6beta4 integrin contributes to tamoxifen resistance in ERbeta1-negative breast carcinomas, PLoS ONE 2008;3(2):e1592.
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