Timeline
Francina Langa Vives
Head of Structure
04 Oct 2024
publication
Nr5a2 is dispensable for zygotic genome activation but essential for morula development
Read more25 Aug 2023
publication
A human immune system (HIS) mouse model that dissociates roles for mouse and human FcR+ cells during antibody-mediated immune responses.
Read more18 Apr 2023
publication
Mice Humanized for MHC and hACE2 with High Permissiveness to SARS-CoV-2 Omicron Replication.
Read more23 Aug 2022
publication
SPICE-Met: profiling and imaging energy metabolism at the single-cell level using a fluorescent reporter mouse.
Read more27 Apr 2022
publication
An intranasal lentiviral booster reinforces the waning mRNA vaccine-induced SARS-CoV-2 immunity that it targets to lung mucosa.
Read more24 Feb 2022
publication
A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.
Read more07 Dec 2021
publication
Brain cross-protection against SARS-CoV-2 variants by a lentiviral vaccine in new transgenic mice.
Read more23 Nov 2021
publication
De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes.
Read more14 Sep 2021
publication
The antitumoral effects of chemerin are independent from leukocyte recruitment and mediated by inhibition of neoangiogenesis.
Read more10 Aug 2021
publication
The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium.
Read more18 Feb 2021
publication
Dynamics of myogenic differentiation using a novel Myogenin knock-in reporter mouse.
Read more01 Feb 2021
publication
The ring finger protein 213 gene (Rnf213) contributes to Rift Valley fever resistance in mice.
Read more19 Jan 2021
publication
Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy.
Read more01 Jan 2021
publication
Lysosomal Acid Lipase Drives Adipocyte Cholesterol Homeostasis and Modulates Lipid Storage in Obesity, Independent of Autophagy.
Read more01 Oct 2020
publication
Mitochondrial AIF loss causes metabolic reprogramming, caspase-independent cell death blockade, embryonic lethality, and perinatal hydrocephalus.
Read more05 Jun 2020
publication
Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth.
Read more15 Nov 2019
publication
Expression of Bioactive Chemerin by Keratinocytes Inhibits Late Stages of Tumor Development in a Chemical Model of Skin Carcinogenesis
Read more06 Jun 2019
publication
Impaired telomere integrity and rRNA biogenesis in PARN-deficient patients and knock-out models
Read more01 Jan 2019
publication
A distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero-posterior patterning of esophagus striated muscle
Read more22 Oct 2018
publication
A Human Polymorphism in CHRNA5 Is Linked to Relapse to Nicotine Seeking in Transgenic Rats.
Read more17 Dec 2017
publication
Reduced recruitment of 53BP1 during interstrand crosslink repair is associated with genetically inherited attenuation of mitomycin C sensitivity in a family with Fanconi anemia
Read more14 Dec 2017
26 Sep 2016
publication
The circadian gene Arntl2 on distal mouse chromosome 6 controls thymocyte apoptosis
Read more30 Aug 2016
publication
The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination
Read more22 Apr 2016
publication
Generation of a Double KO Mouse by Simultaneous Targeting of the Neighboring Genes Tmem176a and Tmem176b Using CRISPR/Cas9: Key Steps from Design to Genotyping
Read more08 Jan 2016
publication
Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts
Read more04 Nov 2015
publication
Fine-tuning the onset of myogenesis by homeobox proteins that interact with the Myf5 limb enhancer
Read more17 Feb 2015
06 Feb 2015
26 Jan 2015
26 Jan 2015
project
Gene editing by specific nucleases (zinc finger nucleases-zfns, tale nucleases, CRISPR/Cas9 system)
Read more26 Jan 2015
project
Microinjection of “External” Mutant ES Cells And Subsequently Germ-Line Chimera Generation
Read more26 Jan 2015
26 Jan 2015
26 Jan 2015
27 Jun 2014
publication
Human hematopoietic reconstitution and HLA-restricted responses in nonpermissive alymphoid mice
Read more24 Jun 2014
publication
A novel nodal enhancer dependent on pluripotency factors and smad2/3 signaling conditions a regulatory switch during epiblast maturation
Read more06 Jun 2014
publication
Cellular and behavioral outcomes of dorsal striatonigral neuron ablation: new insights into striatal functions
Read more04 May 2014
publication
Associations of HLA-A, HLA-B and HLA-C alleles frequency with prevalence of herpes simplex virus infections and diseases across global populations: implication for the development of an universal CD8+ T-cell epitope-based vaccine
Read more03 Feb 2014
17 Jun 2013
publication
HLA-A*01:03, HLA-A*24:02, HLA-B*08:01, HLA-B*27:05, HLA-B*35:01, HLA-B*44:02, and HLA-C*07:01 monochain transgenic/H-2 class I null mice: novel versatile preclinical models of human T cell responses
Read more12 Jun 2013
publication
Penicillin resistance compromises Nod1-dependent proinflammatory activity and virulence fitness of neisseria meningitidis.
Read more20 Dec 2012
publication
Generation and characterization of a tamoxifen inducible Msx1(CreERT2) knock-in allele
Read more29 Jul 2012
publication
Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury
Read more11 Jul 2012
publication
The four and a half LIM-only protein 2 regulates liver homeostasis and contributes to carcinogenesis
Read more26 Jun 2012
publication
I-SceI-mediated double-strand break does not increase the frequency of homologous recombination at the Dct locus in mouse embryonic stem cells
Read more01 Apr 2012
publication
Loss of central and peripheral CD8+ T-cell tolerance to HFE in mouse models of human familial hemochromatosis
Read more18 Oct 2011
publication
Mouse PRDM9 DNA-binding specificity determines sites of histone H3 lysine 4 trimethylation for initiation of meiotic recombination
Read more23 Sep 2010
24 Dec 2009
publication
Progressive Purkinje cell degeneration in tambaleante mutant mice is a consequence of a missense mutation in HERC1 E3 ubiquitin ligase
Read more21 Jan 2009
23 Oct 2008
publication
Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis.
Read more26 May 2008
publication
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells
Read more01 May 2008
23 Mar 2007
publication
Conditional knock-out reveals that zygotic vezatin-null mouse embryos die at implantation
Read more01 Mar 2007
25 Jun 2006
publication