Timeline

Francina Langa Vives

Head of Structure

25 Aug 2023

publication

A human immune system (HIS) mouse model that dissociates roles for mouse and human FcR+ cells during antibody-mediated immune responses.

18 Apr 2023

publication

Mice Humanized for MHC and hACE2 with High Permissiveness to SARS-CoV-2 Omicron Replication.

23 Aug 2022

publication

SPICE-Met: profiling and imaging energy metabolism at the single-cell level using a fluorescent reporter mouse.

27 Apr 2022

publication

An intranasal lentiviral booster reinforces the waning mRNA vaccine-induced SARS-CoV-2 immunity that it targets to lung mucosa.

24 Feb 2022

publication

A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.

07 Dec 2021

publication

Brain cross-protection against SARS-CoV-2 variants by a lentiviral vaccine in new transgenic mice.

23 Nov 2021

publication

De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes.

14 Sep 2021

publication

The antitumoral effects of chemerin are independent from leukocyte recruitment and mediated by inhibition of neoangiogenesis.

10 Aug 2021

publication

The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium.

18 Feb 2021

publication

Dynamics of myogenic differentiation using a novel Myogenin knock-in reporter mouse.

01 Feb 2021

publication

The ring finger protein 213 gene (Rnf213) contributes to Rift Valley fever resistance in mice.

19 Jan 2021

publication

Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy.

01 Jan 2021

publication

Lysosomal Acid Lipase Drives Adipocyte Cholesterol Homeostasis and Modulates Lipid Storage in Obesity, Independent of Autophagy.

01 Oct 2020

publication

Mitochondrial AIF loss causes metabolic reprogramming, caspase-independent cell death blockade, embryonic lethality, and perinatal hydrocephalus.

05 Jun 2020

publication

Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth.

15 Nov 2019

publication

Expression of Bioactive Chemerin by Keratinocytes Inhibits Late Stages of Tumor Development in a Chemical Model of Skin Carcinogenesis

06 Jun 2019

publication

Impaired telomere integrity and rRNA biogenesis in PARN-deficient patients and knock-out models

01 Jan 2019

publication

A distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero-posterior patterning of esophagus striated muscle

22 Oct 2018

publication

A Human Polymorphism in CHRNA5 Is Linked to Relapse to Nicotine Seeking in Transgenic Rats.

17 Dec 2017

publication

Reduced recruitment of 53BP1 during interstrand crosslink repair is associated with genetically inherited attenuation of mitomycin C sensitivity in a family with Fanconi anemia

14 Dec 2017

publication

MITF – A controls branching morphogenesis and nephron endowment

26 Sep 2016

publication

The circadian gene Arntl2 on distal mouse chromosome 6 controls thymocyte apoptosis

30 Aug 2016

publication

The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination

22 Apr 2016

publication

Generation of a Double KO Mouse by Simultaneous Targeting of the Neighboring Genes Tmem176a and Tmem176b Using CRISPR/Cas9: Key Steps from Design to Genotyping

08 Jan 2016

publication

Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts

04 Nov 2015

publication

Fine-tuning the onset of myogenesis by homeobox proteins that interact with the Myf5 limb enhancer

17 Feb 2015

team

Mouse Genetics Engineering

06 Feb 2015

project

Rat transgenesis

26 Jan 2015

project

Genome modifications by CRISPR/cas9 system

26 Jan 2015

project

Gene editing by specific nucleases (zinc finger nucleases-zfns, tale nucleases, CRISPR/Cas9 system)

26 Jan 2015

project

Microinjection of “External” Mutant ES Cells And Subsequently Germ-Line Chimera Generation

26 Jan 2015

project

Lentiviral Transgenesis

26 Jan 2015

project

Targeted Transgenesis By Homologous Recombination In Embryonic Stem (ES) Cells

26 Jan 2015

project

Classical/Additive Transgenesis by Microinjection

27 Jun 2014

publication

Human hematopoietic reconstitution and HLA-restricted responses in nonpermissive alymphoid mice

24 Jun 2014

publication

A novel nodal enhancer dependent on pluripotency factors and smad2/3 signaling conditions a regulatory switch during epiblast maturation

06 Jun 2014

publication

Cellular and behavioral outcomes of dorsal striatonigral neuron ablation: new insights into striatal functions

04 May 2014

publication

Associations of HLA-A, HLA-B and HLA-C alleles frequency with prevalence of herpes simplex virus infections and diseases across global populations: implication for the development of an universal CD8+ T-cell epitope-based vaccine

03 Feb 2014

publication

Protective role of LGP2 in influenza virus pathogenesis

17 Jun 2013

publication

HLA-A01:03, HLA-A24:02, HLA-B08:01, HLA-B27:05, HLA-B35:01, HLA-B44:02, and HLA-C*07:01 monochain transgenic/H-2 class I null mice: novel versatile preclinical models of human T cell responses

12 Jun 2013

publication

Penicillin resistance compromises Nod1-dependent proinflammatory activity and virulence fitness of neisseria meningitidis.

20 Dec 2012

publication

Generation and characterization of a tamoxifen inducible Msx1(CreERT2) knock-in allele

29 Jul 2012

publication

Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury

11 Jul 2012

publication

The four and a half LIM-only protein 2 regulates liver homeostasis and contributes to carcinogenesis

26 Jun 2012

publication

I-SceI-mediated double-strand break does not increase the frequency of homologous recombination at the Dct locus in mouse embryonic stem cells

01 Apr 2012

publication

Loss of central and peripheral CD8+ T-cell tolerance to HFE in mouse models of human familial hemochromatosis

18 Oct 2011

publication

Mouse PRDM9 DNA-binding specificity determines sites of histone H3 lysine 4 trimethylation for initiation of meiotic recombination

23 Sep 2010

publication

Lineage relationship analysis of RORgammat+ innate lymphoid cells

24 Dec 2009

publication

Progressive Purkinje cell degeneration in tambaleante mutant mice is a consequence of a missense mutation in HERC1 E3 ubiquitin ligase

21 Jan 2009

publication

Characterization of the thymic IL-7 niche in vivo

23 Oct 2008

publication

Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis.

26 May 2008

publication

In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells

01 May 2008

publication

Generation of an Msx2-GFP conditional null allele

23 Mar 2007

publication

Conditional knock-out reveals that zygotic vezatin-null mouse embryos die at implantation

01 Mar 2007

publication

The archetypal R90C CADASIL-NOTCH3 mutation retains NOTCH3 function in vivo

25 Jun 2006

publication

A little guide for advanced search:

A human immune system (HIS) mouse model that dissociates roles for mouse and human FcR+ cells during antibody-mediated immune responses.

Mice Humanized for MHC and hACE2 with High Permissiveness to SARS-CoV-2 Omicron Replication.

SPICE-Met: profiling and imaging energy metabolism at the single-cell level using a fluorescent reporter mouse.

An intranasal lentiviral booster reinforces the waning mRNA vaccine-induced SARS-CoV-2 immunity that it targets to lung mucosa.

A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.

Brain cross-protection against SARS-CoV-2 variants by a lentiviral vaccine in new transgenic mice.

De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes.

The antitumoral effects of chemerin are independent from leukocyte recruitment and mediated by inhibition of neoangiogenesis.

The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium.

Dynamics of myogenic differentiation using a novel Myogenin knock-in reporter mouse.

The ring finger protein 213 gene (Rnf213) contributes to Rift Valley fever resistance in mice.

Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy.

Lysosomal Acid Lipase Drives Adipocyte Cholesterol Homeostasis and Modulates Lipid Storage in Obesity, Independent of Autophagy.

Mitochondrial AIF loss causes metabolic reprogramming, caspase-independent cell death blockade, embryonic lethality, and perinatal hydrocephalus.

Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth.

Expression of Bioactive Chemerin by Keratinocytes Inhibits Late Stages of Tumor Development in a Chemical Model of Skin Carcinogenesis

Impaired telomere integrity and rRNA biogenesis in PARN-deficient patients and knock-out models

A distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero-posterior patterning of esophagus striated muscle

A Human Polymorphism in CHRNA5 Is Linked to Relapse to Nicotine Seeking in Transgenic Rats.

Reduced recruitment of 53BP1 during interstrand crosslink repair is associated with genetically inherited attenuation of mitomycin C sensitivity in a family with Fanconi anemia

MITF – A controls branching morphogenesis and nephron endowment

The circadian gene Arntl2 on distal mouse chromosome 6 controls thymocyte apoptosis

The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination

Generation of a Double KO Mouse by Simultaneous Targeting of the Neighboring Genes Tmem176a and Tmem176b Using CRISPR/Cas9: Key Steps from Design to Genotyping

Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts

Fine-tuning the onset of myogenesis by homeobox proteins that interact with the Myf5 limb enhancer

Mouse Genetics Engineering

Rat transgenesis

Genome modifications by CRISPR/cas9 system

Gene editing by specific nucleases (zinc finger nucleases-zfns, tale nucleases, CRISPR/Cas9 system)

Microinjection of “External” Mutant ES Cells And Subsequently Germ-Line Chimera Generation

Lentiviral Transgenesis

Targeted Transgenesis By Homologous Recombination In Embryonic Stem (ES) Cells

Classical/Additive Transgenesis by Microinjection

Human hematopoietic reconstitution and HLA-restricted responses in nonpermissive alymphoid mice

A novel nodal enhancer dependent on pluripotency factors and smad2/3 signaling conditions a regulatory switch during epiblast maturation

Cellular and behavioral outcomes of dorsal striatonigral neuron ablation: new insights into striatal functions

Associations of HLA-A, HLA-B and HLA-C alleles frequency with prevalence of herpes simplex virus infections and diseases across global populations: implication for the development of an universal CD8+ T-cell epitope-based vaccine

Protective role of LGP2 in influenza virus pathogenesis

HLA-A*01:03, HLA-A*24:02, HLA-B*08:01, HLA-B*27:05, HLA-B*35:01, HLA-B*44:02, and HLA-C*07:01 monochain transgenic/H-2 class I null mice: novel versatile preclinical models of human T cell responses

Penicillin resistance compromises Nod1-dependent proinflammatory activity and virulence fitness of neisseria meningitidis.

Generation and characterization of a tamoxifen inducible Msx1(CreERT2) knock-in allele

Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury

The four and a half LIM-only protein 2 regulates liver homeostasis and contributes to carcinogenesis

I-SceI-mediated double-strand break does not increase the frequency of homologous recombination at the Dct locus in mouse embryonic stem cells

Loss of central and peripheral CD8+ T-cell tolerance to HFE in mouse models of human familial hemochromatosis

Mouse PRDM9 DNA-binding specificity determines sites of histone H3 lysine 4 trimethylation for initiation of meiotic recombination

Lineage relationship analysis of RORgammat+ innate lymphoid cells

Progressive Purkinje cell degeneration in tambaleante mutant mice is a consequence of a missense mutation in HERC1 E3 ubiquitin ligase

Characterization of the thymic IL-7 niche in vivo

Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis.

In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells

Generation of an Msx2-GFP conditional null allele

Conditional knock-out reveals that zygotic vezatin-null mouse embryos die at implantation

The archetypal R90C CADASIL-NOTCH3 mutation retains NOTCH3 function in vivo

Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy

HLA-A01:03, HLA-A24:02, HLA-B08:01, HLA-B27:05, HLA-B35:01, HLA-B44:02, and HLA-C*07:01 monochain transgenic/H-2 class I null mice: novel versatile preclinical models of human T cell responses