Ligne de temps
Francina Langa Vives
Responsable de Structure
25 août 2023
publication
A human immune system (HIS) mouse model that dissociates roles for mouse and human FcR+ cells during antibody-mediated immune responses.
Lire plus18 avr. 2023
publication
Mice Humanized for MHC and hACE2 with High Permissiveness to SARS-CoV-2 Omicron Replication.
Lire plus23 août 2022
publication
SPICE-Met: profiling and imaging energy metabolism at the single-cell level using a fluorescent reporter mouse.
Lire plus27 avr. 2022
publication
An intranasal lentiviral booster reinforces the waning mRNA vaccine-induced SARS-CoV-2 immunity that it targets to lung mucosa.
Lire plus24 févr. 2022
publication
A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.
Lire plus07 déc. 2021
publication
Brain cross-protection against SARS-CoV-2 variants by a lentiviral vaccine in new transgenic mice.
Lire plus23 nov. 2021
publication
De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes.
Lire plus14 sept. 2021
publication
The antitumoral effects of chemerin are independent from leukocyte recruitment and mediated by inhibition of neoangiogenesis.
Lire plus10 août 2021
publication
The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium.
Lire plus18 févr. 2021
publication
Dynamics of myogenic differentiation using a novel Myogenin knock-in reporter mouse.
Lire plus01 févr. 2021
publication
The ring finger protein 213 gene (Rnf213) contributes to Rift Valley fever resistance in mice.
Lire plus19 janv. 2021
publication
Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy.
Lire plus01 janv. 2021
publication
Lysosomal Acid Lipase Drives Adipocyte Cholesterol Homeostasis and Modulates Lipid Storage in Obesity, Independent of Autophagy.
Lire plus01 oct. 2020
publication
Mitochondrial AIF loss causes metabolic reprogramming, caspase-independent cell death blockade, embryonic lethality, and perinatal hydrocephalus.
Lire plus05 juin 2020
publication
Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth.
Lire plus15 nov. 2019
publication
Expression of Bioactive Chemerin by Keratinocytes Inhibits Late Stages of Tumor Development in a Chemical Model of Skin Carcinogenesis
Lire plus06 juin 2019
publication
Impaired telomere integrity and rRNA biogenesis in PARN-deficient patients and knock-out models
Lire plus01 janv. 2019
publication
A distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero-posterior patterning of esophagus striated muscle
Lire plus22 oct. 2018
publication
A Human Polymorphism in CHRNA5 Is Linked to Relapse to Nicotine Seeking in Transgenic Rats.
Lire plus17 déc. 2017
publication
Reduced recruitment of 53BP1 during interstrand crosslink repair is associated with genetically inherited attenuation of mitomycin C sensitivity in a family with Fanconi anemia
Lire plus14 déc. 2017
26 sept. 2016
publication
The circadian gene Arntl2 on distal mouse chromosome 6 controls thymocyte apoptosis
Lire plus30 août 2016
publication
The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination
Lire plus22 avr. 2016
publication
Generation of a Double KO Mouse by Simultaneous Targeting of the Neighboring Genes Tmem176a and Tmem176b Using CRISPR/Cas9: Key Steps from Design to Genotyping
Lire plus08 janv. 2016
publication
Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts
Lire plus04 nov. 2015
publication
Fine-tuning the onset of myogenesis by homeobox proteins that interact with the Myf5 limb enhancer
Lire plus17 févr. 2015
06 févr. 2015
26 janv. 2015
26 janv. 2015
project
Gene editing by specific nucleases (zinc finger nucleases-zfns, tale nucleases, CRISPR/Cas9 system)
Lire plus26 janv. 2015
project
Microinjection of “External” Mutant ES Cells And Subsequently Germ-Line Chimera Generation
Lire plus26 janv. 2015
26 janv. 2015
26 janv. 2015
27 juin 2014
publication
Human hematopoietic reconstitution and HLA-restricted responses in nonpermissive alymphoid mice
Lire plus24 juin 2014
publication
A novel nodal enhancer dependent on pluripotency factors and smad2/3 signaling conditions a regulatory switch during epiblast maturation
Lire plus06 juin 2014
publication
Cellular and behavioral outcomes of dorsal striatonigral neuron ablation: new insights into striatal functions
Lire plus04 mai 2014
publication
Associations of HLA-A, HLA-B and HLA-C alleles frequency with prevalence of herpes simplex virus infections and diseases across global populations: implication for the development of an universal CD8+ T-cell epitope-based vaccine
Lire plus03 févr. 2014
17 juin 2013
publication
HLA-A*01:03, HLA-A*24:02, HLA-B*08:01, HLA-B*27:05, HLA-B*35:01, HLA-B*44:02, and HLA-C*07:01 monochain transgenic/H-2 class I null mice: novel versatile preclinical models of human T cell responses
Lire plus12 juin 2013
publication
Penicillin resistance compromises Nod1-dependent proinflammatory activity and virulence fitness of neisseria meningitidis.
Lire plus20 déc. 2012
publication
Generation and characterization of a tamoxifen inducible Msx1(CreERT2) knock-in allele
Lire plus29 juil. 2012
publication
Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury
Lire plus11 juil. 2012
publication
The four and a half LIM-only protein 2 regulates liver homeostasis and contributes to carcinogenesis
Lire plus26 juin 2012
publication
I-SceI-mediated double-strand break does not increase the frequency of homologous recombination at the Dct locus in mouse embryonic stem cells
Lire plus01 avr. 2012
publication
Loss of central and peripheral CD8+ T-cell tolerance to HFE in mouse models of human familial hemochromatosis
Lire plus18 oct. 2011
publication
Mouse PRDM9 DNA-binding specificity determines sites of histone H3 lysine 4 trimethylation for initiation of meiotic recombination
Lire plus23 sept. 2010
24 déc. 2009
publication
Progressive Purkinje cell degeneration in tambaleante mutant mice is a consequence of a missense mutation in HERC1 E3 ubiquitin ligase
Lire plus21 janv. 2009
23 oct. 2008
publication
Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis.
Lire plus26 mai 2008
publication
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells
Lire plus01 mai 2008
23 mars 2007
publication
Conditional knock-out reveals that zygotic vezatin-null mouse embryos die at implantation
Lire plus01 mars 2007
25 juin 2006
publication