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© Research
Project

Gene editing by specific nucleases (zinc finger nucleases-zfns, tale nucleases, CRISPR/Cas9 system)

Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
26
Jan 2015
Status
Ongoing
Members
4
Structures
1

About

The nucleases (ZFN pairs, TALE pairs, Cas9/CRISPR system) are microinjected, mainly in its mRNA form, into the pronucleus and/or the cytoplasm of one-cell mouse/rat embryos in order to get the desired targeted modification. These efficient, specific and versatile techniques bypass the need of Embryonic Stem cells for targeted transgenesis by homologous recombination, simplifying and reducing the time required to create genetically-modified in vivo models.