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© Research
Publication : Science (New York, N.Y.)

Lineage relationship analysis of RORgammat+ innate lymphoid cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 23 Sep 2010

Sawa S, Cherrier M, Lochner M, Satoh-Takayama N, Fehling HJ, Langa F, Di Santo JP, Eberl G

Link to Pubmed [PMID] – 20929731

Science 2010 Oct;330(6004):665-9

Lymphoid tissue-inducer (LTi) cells initiate the development of lymphoid tissues through the activation of local stromal cells in a process similar to inflammation. LTi cells express the nuclear hormone receptor RORγt, which also directs the expression of the proinflammatory cytokine interleukin-17 in T cells. We show here that LTi cells are part of a larger family of proinflammatory RORγt(+) innate lymphoid cells (ILCs) that differentiate from distinct fetal liver RORγt(+) precursors. The fate of RORγt(+) ILCs is determined by mouse age, and after birth, favors the generation of cells involved in intestinal homeostasis and defense. Contrary to RORγt(+) T cells, however, RORγt(+) ILCs develop in the absence of microbiota. Our study indicates that RORγt(+) ILCs evolve to preempt intestinal colonization by microbial symbionts.

https://www.ncbi.nlm.nih.gov/pubmed/20929731