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© Research
Publication : Journal of immunology (Baltimore, Md. : 1950)

Human hematopoietic reconstitution and HLA-restricted responses in nonpermissive alymphoid mice

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of immunology (Baltimore, Md. : 1950) - 27 Jun 2014

Serra-Hassoun M, Bourgine M, Boniotto M, Berges J, Langa F, Michel ML, Freitas AA, Garcia S

Link to Pubmed [PMID] – 24973440

J. Immunol. 2014 Aug;193(3):1504-11

We generated a new humanized mouse model to study HLA-restricted immune responses. For this purpose, we created unique murine hosts by enforcing the expression of human SIRPα by murine phagocytes in murine MHC-deficient HLA-transgenic alymphoid hosts, an approach that allowed the immune reconstitution of nonpermissive mice following injection of human hematopoietic stem cells. We showed that these mouse/human chimeras were able to generate HLA-restricted responses to immunization. These new humanized mice may offer attractive models to study immune responses to human diseases, such as HIV and EBV infections, as well as to assay new vaccine strategies.

http://www.ncbi.nlm.nih.gov/pubmed/24973440