Timeline

Sylvie Pochet
Head of Structure
14 Feb 2020
publication

From Substrate to Fragments to Inhibitor Active against

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03 Jan 2020
publication

An expedient synthesis of flexible nucleosides through enzymatic glycosylation of proximal and distal fleximer bases

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20 Jun 2019
publication

Crystal structure of the Trypanosoma cruzi EIF4E5 translation factor homologue in complex with mRNA cap-4

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02 Jan 2019
team

Organic Chemistry

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02 Jan 2019
publication

2′-Deoxyribonucleoside 5′-triphosphates bearing 4-phenyl and 4-pyrimidinyl imidazoles as DNA polymerase substrates

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06 Jul 2018
publication

Enzymatic synthesis of random sequences of RNA and RNA analogues by DNA polymerase theta mutants for the generation of aptamer libraries

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09 Mar 2018
project

Protein synthesis machinery of Trypanosomatid as a therapeutic target

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12 Sep 2017
publication

An expedient synthesis of flexible nucleosides via a regiocontrolled enzymatic glycosylation of functionalized imidazoles

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29 Nov 2016
publication

8-Thioalkyl-adenosine derivatives inhibit Listeria monocytogenes NAD kinase through a novel binding mode

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18 Nov 2016
team

Group : Sylvie Pochet

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18 Oct 2016
publication

8-Thioalkyl-adenosine derivatives inhibit Listeria monocytogenes NAD kinase through a novel binding mode

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28 Apr 2016
event

2016 XXII IRT

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11 Mar 2016
publication

Expedient and generic synthesis of imidazole nucleosides by enzymatic transglycosylation

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07 Sep 2015
project

FP7 Targeting the Leishmania kinome for the development of novel anti-parasitic strategies (LeishDrug)

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03 Sep 2015
project

Inhibitors of Pseudomonas aeruginosa IMPDH

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20 Aug 2015
project

Inhibitors of TMPK from Mycobacterium tuberculosis

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03 Aug 2015
patent

NOVEL ANTIBACTERIAL COMPOUNDS

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03 Aug 2015
project

Inhibitors of the 2’-deoxyribonucleotide N-hydrolase DNPH1, an enzyme involved in cellular growth and angiogenesis

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28 Jul 2015
project

Inhibitors of bacterial NAD kinases

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11 May 2015
team

Chemistry and Biocatalysis

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29 Apr 2015
publication

Unprecedented formation of 8(R),5′-O-cycloribonucleosides through a triflation reaction of purine ribonucleosides

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12 Nov 2014
publication

A convenient synthesis of 4(5)-(hetero)aryl-1H-imidazoles via microwave-assisted Suzuki-Miyaura cross-coupling reaction

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01 Aug 2014
publication

6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities

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26 Feb 2014
publication

Synthesis of novel 9-aryl and heteroarylpurine derivatives via copper mediated coupling reaction

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19 Nov 2013
publication

N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1

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19 Jan 2013
publication

Structure of the oncoprotein Rcl bound to three nucleotide analogues

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17 May 2012
publication

Screening and in situ synthesis using crystals of a NAD kinase lead to a potent antistaphylococcal compound

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01 Jan 2012
publication

Drug design and identification of potent leads against mycobacterium tuberculosis thymidine monophosphate kinase

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09 Aug 2011
publication

In-plate protein crystallization, in situ ligand soaking and X-ray diffraction

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20 Oct 2010
publication

Probing the active site of the deoxynucleotide N-hydrolase Rcl encoded by the rat gene c6orf108

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29 Oct 2008
publication

Crystal structure of poxvirus thymidylate kinase: an unexpected dimerization has implications for antiviral therapy

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16 May 2008
publication

In vivo reshaping the catalytic site of nucleoside 2′-deoxyribosyltransferase for dideoxy- and didehydronucleosides via a single amino acid substitution

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25 Apr 2008
publication

Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity

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01 Jan 2008
publication

Expanding substrate specificity of nucleoside 2′-deoxyribosyltransferase

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08 Aug 2007
publication

NAD kinases use substrate-assisted catalysis for specific recognition of NAD

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10 Jul 2007
publication

Enantioselectivity of human AMP, dTMP and UMP-CMP kinases

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02 Jul 2007
publication

Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives — a screening based on affinity for the UMP-CMP binding site

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01 Jan 2007
publication

Looking for new pyrimidine acyclic nucleotide analogues designed for phosphorylation by human UMP-CMP kinase

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01 Jan 2007
publication

A new family of inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

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01 Jan 2007
publication

Crystal structure and photochemical behavior in solution of the 3′-N-sulfamate analogue of thymidylyl(3′-5′)thymidine

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27 Oct 2006
publication

Recognition of nucleotide analogs containing the 7,8-dihydro-8-oxo structure by the human MTH1 protein

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01 Dec 2005
publication

Substrate specificity of vaccinia virus thymidylate kinase

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01 Apr 2005
publication

Mechanism of the antiviral action of 1-beta-D-arabinofuranosylcytosine on Borna disease virus

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01 Apr 2005
publication

LEA3D: a computer-aided ligand design for structure-based drug design

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15 Feb 2005
publication

Synthesis and incorporation into DNA fragments of the artificial nucleobase, 2-amino-8-oxopurine

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30 Apr 2004
publication

APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptase

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01 Apr 2004
publication

2′-fluoro-2′-deoxycytidine inhibits Borna disease virus replication and spread

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27 Feb 2004
publication

Probing the substrate recognition mechanism of the human MTH1 protein by nucleotide analogs

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01 Dec 2003
publication

Replication of hexitol oligonucleotides as a prelude to the propagation of a third type of nucleic acid in vivo

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15 Sep 2003
publication

Thymidine and thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

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28 Aug 2003
publication

3′-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

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01 Aug 2003
publication

Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans

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01 May 2003
publication

Synthesis and recognition by DNA polymerases of a reactive nucleoside for DNA diversification

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01 May 2003
publication

Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors

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01 Mar 2003
publication

A short path synthesis of [13C/15N] multilabeled pyrimidine nucleosides starting from glucopyranose nucleosides

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01 Dec 2002
publication

A parallel synthesis scheme for generating libraries of DNA polymerase substrates and inhibitors

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01 Oct 2002
publication

Synthesis and evaluation of thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

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01 May 2002
publication

Synthesis and recognition by DNA polymerases of a reactive nucleoside, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-imidazole-4-hydrazide

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01 Jan 2002
publication

Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications

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01 Jan 2002
publication

Substrate recognition by the human MTH1 protein

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01 Aug 2001
publication

Reverse transcriptase incorporation of 1,5-anhydrohexitol nucleotides

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01 Jun 2001
publication

Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes

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24 Oct 2000
publication

Enzymatic incorporation in DNA of 1,5-anhydrohexitol nucleotides

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01 Jul 1999
publication

Assay of nucleoside 2-deoxyribosyltransferase activity with pyruvate kinase/lactate dehydrogenase coupling system

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01 Sep 1996
publication

Ambiguous base pairing of the purine analogue 1-(2-deoxy-beta-D-ribofuranosyl)-imidazole-4-carboxamide during PCR

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01 Jan 1996
publication

Construction of a self-complementary nucleoside from deoxyguanosine

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15 Feb 1994
publication

Genetic characterization of polypeptide deformylase, a distinctive enzyme of eubacterial translation

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25 Dec 1993
publication

Directed evolution of biosynthetic pathways. Recruitment of cysteine thioethers for constructing the cell wall of Escherichia coli

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11 Dec 1990
publication

Synthesis and enzymatic polymerisation of 5-amino-1-(2′-deoxy-beta-D-ribofuranosyl)imidazole-4-carboxamide-5′- triphosphate

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01 Feb 1989
publication

Preparation and use of a universal primed Sepharose for the purification of DNA-binding proteins

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01 Aug 1988
publication

IR and UV studies on stability and conformations of short DNA duplexes containing a no-base residue: coexistence of B and Z conformations

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25 Feb 1988
publication

Solid-supported ligation primer

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24 Jan 1986
publication

NMR, CD and IR spectroscopies of a tridecanucleotide containing a no-base residue: coexistence of B and Z conformations

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