Timeline
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Sylvie Pochet
Group Leader
15 Jan 2023
publication
Synthesis and structure-activity relationship studies of original cyclic diadenosine derivatives as nanomolar inhibitors of NAD kinase from pathogenic bacteria.
Read more29 Aug 2022
publication
Structure-based design, synthesis and biological evaluation of a NAD+ analogue targeting Pseudomonas aeruginosa NAD kinase.
Read more30 Apr 2021
22 Oct 2020
13 Mar 2020
publication
From Substrate to Fragments to Inhibitor Active In Vivo against Staphylococcus aureus.
Read more03 Jan 2020
publication
An expedient synthesis of flexible nucleosides through enzymatic glycosylation of proximal and distal fleximer bases
Read more20 Jun 2019
publication
Crystal structure of the Trypanosoma cruzi EIF4E5 translation factor homologue in complex with mRNA cap-4
Read more02 Jan 2019
publication
2′-Deoxyribonucleoside 5′-triphosphates bearing 4-phenyl and 4-pyrimidinyl imidazoles as DNA polymerase substrates
Read more06 Jul 2018
publication
Enzymatic synthesis of random sequences of RNA and RNA analogues by DNA polymerase theta mutants for the generation of aptamer libraries
Read more09 Mar 2018
12 Sep 2017
publication
An expedient synthesis of flexible nucleosides via a regiocontrolled enzymatic glycosylation of functionalized imidazoles
Read more29 Nov 2016
publication
8-Thioalkyl-adenosine derivatives inhibit Listeria monocytogenes NAD kinase through a novel binding mode.
Read more28 Apr 2016
11 Mar 2016
publication
Expedient and generic synthesis of imidazole nucleosides by enzymatic transglycosylation
Read more07 Sep 2015
project
FP7 Targeting the Leishmania kinome for the development of novel anti-parasitic strategies (LeishDrug)
Read more03 Sep 2015
20 Aug 2015
03 Aug 2015
03 Aug 2015
project
Inhibitors of the 2’-deoxyribonucleotide N-hydrolase DNPH1, an enzyme involved in cellular growth and angiogenesis
Read more28 Jul 2015
29 Apr 2015
publication
Unprecedented formation of 8(R),5′-O-cycloribonucleosides through a triflation reaction of purine ribonucleosides
Read more12 Nov 2014
publication
A convenient synthesis of 4(5)-(hetero)aryl-1H-imidazoles via microwave-assisted Suzuki-Miyaura cross-coupling reaction
Read more01 Aug 2014
publication
6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities
Read more26 Feb 2014
publication
Synthesis of novel 9-aryl and heteroarylpurine derivatives via copper mediated coupling reaction
Read more19 Nov 2013
19 Jan 2013
06 Jun 2012
publication
Screening and in situ synthesis using crystals of a NAD kinase lead to a potent antistaphylococcal compound.
Read more01 Jan 2012
publication
Drug design and identification of potent leads against mycobacterium tuberculosis thymidine monophosphate kinase
Read more09 Aug 2011
publication
In-plate protein crystallization, in situ ligand soaking and X-ray diffraction
Read more20 Oct 2010
publication
Probing the active site of the deoxynucleotide N-hydrolase Rcl encoded by the rat gene c6orf108
Read more29 Oct 2008
publication
Crystal structure of poxvirus thymidylate kinase: an unexpected dimerization has implications for antiviral therapy
Read more16 May 2008
publication
In vivo reshaping the catalytic site of nucleoside 2′-deoxyribosyltransferase for dideoxy- and didehydronucleosides via a single amino acid substitution
Read more25 Apr 2008
publication
Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity
Read more01 Jan 2008
08 Aug 2007
10 Jul 2007
02 Jul 2007
publication
Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives — a screening based on affinity for the UMP-CMP binding site
Read more01 Jan 2007
publication
A new family of inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase
Read more01 Jan 2007
publication
Crystal structure and photochemical behavior in solution of the 3′-N-sulfamate analogue of thymidylyl(3′-5′)thymidine
Read more01 Jan 2007
publication
Looking for new pyrimidine acyclic nucleotide analogues designed for phosphorylation by human UMP-CMP kinase
Read more27 Oct 2006
publication
Recognition of nucleotide analogs containing the 7,8-dihydro-8-oxo structure by the human MTH1 protein
Read more01 Dec 2005
01 Apr 2005
publication
Mechanism of the antiviral action of 1-beta-D-arabinofuranosylcytosine on Borna disease virus
Read more01 Apr 2005
15 Feb 2005
publication
Synthesis and incorporation into DNA fragments of the artificial nucleobase, 2-amino-8-oxopurine
Read more30 Apr 2004
publication
APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptase
Read more01 Apr 2004
publication
2′-fluoro-2′-deoxycytidine inhibits Borna disease virus replication and spread
Read more27 Feb 2004
publication
Probing the substrate recognition mechanism of the human MTH1 protein by nucleotide analogs
Read more01 Dec 2003
publication
Replication of hexitol oligonucleotides as a prelude to the propagation of a third type of nucleic acid in vivo
Read more15 Sep 2003
publication
Thymidine and thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase
Read more28 Aug 2003
publication
3′-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase
Read more01 Aug 2003
publication
Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans
Read more01 May 2003
publication
Synthesis and recognition by DNA polymerases of a reactive nucleoside for DNA diversification
Read more01 May 2003
publication
Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors
Read more01 Mar 2003
publication
A short path synthesis of [13C/15N] multilabeled pyrimidine nucleosides starting from glucopyranose nucleosides
Read more01 Dec 2002
publication
A parallel synthesis scheme for generating libraries of DNA polymerase substrates and inhibitors
Read more01 Oct 2002
publication
Synthesis and evaluation of thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase
Read more01 May 2002
publication
Synthesis and recognition by DNA polymerases of a reactive nucleoside, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-imidazole-4-hydrazide
Read more01 Jan 2002
publication
Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications
Read more01 Jan 2002
01 Aug 2001
01 Jun 2001
publication
Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes
Read more24 Oct 2000
01 Jul 1999
publication
Assay of nucleoside 2-deoxyribosyltransferase activity with pyruvate kinase/lactate dehydrogenase coupling system
Read more01 Sep 1996
publication
Ambiguous base pairing of the purine analogue 1-(2-deoxy-beta-D-ribofuranosyl)-imidazole-4-carboxamide during PCR
Read more01 Jan 1996
15 Feb 1994
publication
Genetic characterization of polypeptide deformylase, a distinctive enzyme of eubacterial translation
Read more25 Dec 1993
publication
Directed evolution of biosynthetic pathways. Recruitment of cysteine thioethers for constructing the cell wall of Escherichia coli
Read more11 Dec 1990
publication
Synthesis and enzymatic polymerisation of 5-amino-1-(2′-deoxy-beta-D-ribofuranosyl)imidazole-4-carboxamide-5′- triphosphate
Read more01 Feb 1989
publication
Preparation and use of a universal primed Sepharose for the purification of DNA-binding proteins
Read more01 Aug 1988
publication
IR and UV studies on stability and conformations of short DNA duplexes containing a no-base residue: coexistence of B and Z conformations
Read more25 Feb 1988
24 Jan 1986
publication