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© Institut Pasteur
Cristaux de cellulase, enzyme purifiée de Clostridium thermocellum permettant la digestion de la cellulose. Image colorisée.
Publication : Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie

Construction of a self-complementary nucleoside from deoxyguanosine

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie - 01 Jan 1996

Pochet S, Marlière P

Link to Pubmed [PMID] – 8673615

C. R. Acad. Sci. III, Sci. Vie 1996 Jan;319(1):1-7

The 8-hydroxyguanine:adenine mispairing scheme that spontaneously occurs in vivo through oxidative metabolism of DNA was edited to obtain a pair closely fitting the Watson-Crick geometry in which 2 purine bases of identical structure but oppositely rotated in the syn and anti configurations are hydrogen-bonded. The structure thus designed, 2-amino-8-hydroxypurine, was synthesized as a DNA precursor from deoxyguanosine in 8 steps by oxidation at carbon 8 of guanine followed by reduction at carbon 6. Polydeoxynucleotides embodying this self-complementary base are expected to undergo direct copying processes through polymerase catalysis.

http://www.ncbi.nlm.nih.gov/pubmed/8673615