Ligne de temps
Sylvie Pochet
Chef(fe) de Groupe
15 janv. 2023
publication
Synthesis and structure-activity relationship studies of original cyclic diadenosine derivatives as nanomolar inhibitors of NAD kinase from pathogenic bacteria.
Lire plus29 août 2022
publication
Structure-based design, synthesis and biological evaluation of a NAD+ analogue targeting Pseudomonas aeruginosa NAD kinase.
Lire plus30 avr. 2021
22 oct. 2020
13 mars 2020
publication
From Substrate to Fragments to Inhibitor Active In Vivo against Staphylococcus aureus.
Lire plus03 janv. 2020
publication
An expedient synthesis of flexible nucleosides through enzymatic glycosylation of proximal and distal fleximer bases
Lire plus20 juin 2019
publication
Crystal structure of the Trypanosoma cruzi EIF4E5 translation factor homologue in complex with mRNA cap-4
Lire plus02 janv. 2019
publication
2′-Deoxyribonucleoside 5′-triphosphates bearing 4-phenyl and 4-pyrimidinyl imidazoles as DNA polymerase substrates
Lire plus06 juil. 2018
publication
Enzymatic synthesis of random sequences of RNA and RNA analogues by DNA polymerase theta mutants for the generation of aptamer libraries
Lire plus09 mars 2018
12 sept. 2017
publication
An expedient synthesis of flexible nucleosides via a regiocontrolled enzymatic glycosylation of functionalized imidazoles
Lire plus29 nov. 2016
publication
8-Thioalkyl-adenosine derivatives inhibit Listeria monocytogenes NAD kinase through a novel binding mode.
Lire plus28 avr. 2016
11 mars 2016
publication
Expedient and generic synthesis of imidazole nucleosides by enzymatic transglycosylation
Lire plus07 sept. 2015
project
FP7 Targeting the Leishmania kinome for the development of novel anti-parasitic strategies (LeishDrug)
Lire plus03 sept. 2015
20 août 2015
03 août 2015
03 août 2015
project
Inhibitors of the 2’-deoxyribonucleotide N-hydrolase DNPH1, an enzyme involved in cellular growth and angiogenesis
Lire plus28 juil. 2015
29 avr. 2015
publication
Unprecedented formation of 8(R),5′-O-cycloribonucleosides through a triflation reaction of purine ribonucleosides
Lire plus12 nov. 2014
publication
A convenient synthesis of 4(5)-(hetero)aryl-1H-imidazoles via microwave-assisted Suzuki-Miyaura cross-coupling reaction
Lire plus01 août 2014
publication
6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities
Lire plus26 févr. 2014
publication
Synthesis of novel 9-aryl and heteroarylpurine derivatives via copper mediated coupling reaction
Lire plus19 nov. 2013
19 janv. 2013
06 juin 2012
publication
Screening and in situ synthesis using crystals of a NAD kinase lead to a potent antistaphylococcal compound.
Lire plus01 janv. 2012
publication
Drug design and identification of potent leads against mycobacterium tuberculosis thymidine monophosphate kinase
Lire plus09 août 2011
publication
In-plate protein crystallization, in situ ligand soaking and X-ray diffraction
Lire plus20 oct. 2010
publication
Probing the active site of the deoxynucleotide N-hydrolase Rcl encoded by the rat gene c6orf108
Lire plus29 oct. 2008
publication
Crystal structure of poxvirus thymidylate kinase: an unexpected dimerization has implications for antiviral therapy
Lire plus16 mai 2008
publication
In vivo reshaping the catalytic site of nucleoside 2′-deoxyribosyltransferase for dideoxy- and didehydronucleosides via a single amino acid substitution
Lire plus25 avr. 2008
publication
Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity
Lire plus01 janv. 2008
08 août 2007
10 juil. 2007
02 juil. 2007
publication
Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives — a screening based on affinity for the UMP-CMP binding site
Lire plus01 janv. 2007
publication
Looking for new pyrimidine acyclic nucleotide analogues designed for phosphorylation by human UMP-CMP kinase
Lire plus01 janv. 2007
publication
A new family of inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase
Lire plus01 janv. 2007
publication
Crystal structure and photochemical behavior in solution of the 3′-N-sulfamate analogue of thymidylyl(3′-5′)thymidine
Lire plus27 oct. 2006
publication
Recognition of nucleotide analogs containing the 7,8-dihydro-8-oxo structure by the human MTH1 protein
Lire plus01 déc. 2005
01 avr. 2005
publication
Mechanism of the antiviral action of 1-beta-D-arabinofuranosylcytosine on Borna disease virus
Lire plus01 avr. 2005
15 févr. 2005
publication
Synthesis and incorporation into DNA fragments of the artificial nucleobase, 2-amino-8-oxopurine
Lire plus30 avr. 2004
publication
APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptase
Lire plus01 avr. 2004
publication
2′-fluoro-2′-deoxycytidine inhibits Borna disease virus replication and spread
Lire plus27 févr. 2004
publication
Probing the substrate recognition mechanism of the human MTH1 protein by nucleotide analogs
Lire plus01 déc. 2003
publication
Replication of hexitol oligonucleotides as a prelude to the propagation of a third type of nucleic acid in vivo
Lire plus15 sept. 2003
publication
Thymidine and thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase
Lire plus28 août 2003
publication
3′-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase
Lire plus01 août 2003
publication
Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans
Lire plus01 mai 2003
publication
Synthesis and recognition by DNA polymerases of a reactive nucleoside for DNA diversification
Lire plus01 mai 2003
publication
Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors
Lire plus01 mars 2003
publication
A short path synthesis of [13C/15N] multilabeled pyrimidine nucleosides starting from glucopyranose nucleosides
Lire plus01 déc. 2002
publication
A parallel synthesis scheme for generating libraries of DNA polymerase substrates and inhibitors
Lire plus01 oct. 2002
publication
Synthesis and evaluation of thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase
Lire plus01 mai 2002
publication
Synthesis and recognition by DNA polymerases of a reactive nucleoside, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-imidazole-4-hydrazide
Lire plus01 janv. 2002
publication
Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications
Lire plus01 janv. 2002
01 août 2001
01 juin 2001
publication
Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes
Lire plus24 oct. 2000
01 juil. 1999
publication
Assay of nucleoside 2-deoxyribosyltransferase activity with pyruvate kinase/lactate dehydrogenase coupling system
Lire plus01 sept. 1996
publication
Ambiguous base pairing of the purine analogue 1-(2-deoxy-beta-D-ribofuranosyl)-imidazole-4-carboxamide during PCR
Lire plus01 janv. 1996
15 févr. 1994
publication
Genetic characterization of polypeptide deformylase, a distinctive enzyme of eubacterial translation
Lire plus25 déc. 1993
publication
Directed evolution of biosynthetic pathways. Recruitment of cysteine thioethers for constructing the cell wall of Escherichia coli
Lire plus11 déc. 1990
publication
Synthesis and enzymatic polymerisation of 5-amino-1-(2′-deoxy-beta-D-ribofuranosyl)imidazole-4-carboxamide-5′- triphosphate
Lire plus01 févr. 1989
publication
Preparation and use of a universal primed Sepharose for the purification of DNA-binding proteins
Lire plus01 août 1988
publication
IR and UV studies on stability and conformations of short DNA duplexes containing a no-base residue: coexistence of B and Z conformations
Lire plus25 févr. 1988
24 janv. 1986
publication