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© Institut Pasteur
Cristaux de cellulase, enzyme purifiée de Clostridium thermocellum permettant la digestion de la cellulose. Image colorisée.
Publication : The Journal of organic chemistry

Crystal structure and photochemical behavior in solution of the 3′-N-sulfamate analogue of thymidylyl(3′-5′)thymidine

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of organic chemistry - 01 Jan 2007

Moriou C, Thomas M, Adeline MT, Martin MT, Chiaroni A, Pochet S, Fourrey JL, Favre A, Clivio P

Link to Pubmed [PMID] – 17194080

J. Org. Chem. 2007 Jan;72(1):43-50

The 3′-N-sulfamate analogue of thymidylyl(3′-5′)thymidine (TnsoT, 1) exhibits a preference for a C3′-endo conformation in the solution and solid states. Its photochemical behavior in solution is compared to that of its natural counterpart, thymidylyl(3′-5′)thymidine (TpT, 2), to get further insight into the significance of the C3′-endo conformation on the photoproduct formation at the single-stranded dinucleotide level. Irradiation at 254 nm of 1 led to the same type of photoproducts as observed with 2. However, 1 was significantly more photoreactive than 2, and accordingly, the initial rate of photoproduct formation was enhanced in accordance with its propensity to base stack compared to 2. The corresponding quantum yields were determined and showed that the enhancement factor (1 compared to 2) is moderate for the cyclobutane pyrimidine dimer (CPD) (1.26) and much higher for the (6-4) photoproduct (1.8). These data strongly suggest that the CPD and (6-4) photoproduct arise from distinct minor stacked conformations.

http://www.ncbi.nlm.nih.gov/pubmed/17194080