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© Institut Pasteur
Cristaux de cellulase, enzyme purifiée de Clostridium thermocellum permettant la digestion de la cellulose. Image colorisée.
Publication : Antimicrobial agents and chemotherapy

2′-fluoro-2′-deoxycytidine inhibits Borna disease virus replication and spread

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 01 Apr 2004

Bajramovic JJ, Volmer R, Syan S, Pochet S, Gonzalez-Dunia D

Link to Pubmed [PMID] – 15047559

Antimicrob. Agents Chemother. 2004 Apr;48(4):1422-5

Borna disease virus (BDV) causes neurological diseases in a variety of warm-blooded animal species, possibly including humans. To date, there is no effective treatment against BDV infection. Recently, we reported on the antiviral activity of 1-beta-D-arabinofuranosylcytosine (Ara-C). However, Ara-C’s cytotoxic side effects are a major obstacle for its therapeutic use. Herein, we demonstrate that the nucleoside analog 2′-fluoro-2′-deoxycytidine (2′-FdC) exhibits potent antiviral activity against BDV. Importantly, 2′-FdC-associated cytotoxicity is negligible, indicating 2′-FdC as an excellent candidate for the development of antiviral therapy against BDV.

http://www.ncbi.nlm.nih.gov/pubmed/15047559